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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619571
Species: Mus musculus
RGD Object: Gene
Symbol: Mapk3
Name: mitogen-activated protein kinase 3
Acc ID: CHEBI:4042
Term: cypermethrin
Definition: A carboxylic ester resulting from the formal condensation between 3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylic acid and the alcoholic hydroxy group of hydroxy(3-phenoxyphenyl)acetonitrile.
Chemical ID: MESH:C017160
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk3multiple interactionsEXP 6480464CTD1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [cypermethrin results in increased phosphorylation of and results in increased activity of MAPK3 protein]; [cypermethrin results in decreased susceptibility to Dihydrotestosterone] which results in decreased phosphorylation of MAPK3 protein; bisindolylmaleimide I inhibits the reaction [cypermethrin results in increased phosphorylation of MAPK3 protein]; cypermethrin results in increased phosphorylation of and results in increased activity of MAPK3 protein; Egtazic Acid inhibits the reaction [cypermethrin results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Nimodipine inhibits the reaction [cypermethrin results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Thapsigargin inhibits the reaction [cypermethrin results in increased phosphorylation of and results in increased activity of MAPK3 protein]; W 7 inhibits the reaction [cypermethrin results in increased phosphorylation of and results in increased activity of MAPK3 protein]PMID:29149324 PMID:30974244
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