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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619551
Species: Homo sapiens
RGD Object: Gene
Symbol: NOS1
Name: nitric oxide synthase 1
Acc ID: CHEBI:3087
Term: betulinic acid
Definition: A pentacyclic triterpenoid that is lupane having a double bond at position 20(29) as well as 3beta-hydroxy and 28-carboxy substituents. It is found in the bark and other plant parts of several species of plants including Syzygium claviflorum. It exhibits anti-HIV, antimalarial, antineoplastic and anti-inflammatory properties.
Chemical ID: MESH:C002070
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
NOS1multiple interactionsEXP 6480464CTDBetulinic Acid inhibits the reaction [Bortezomib results in increased expression of NOS1 protein]PMID:30482226
NOS1multiple interactionsISONos1 (Mus musculus)6480464CTDBetulinic Acid inhibits the reaction [Bortezomib results in increased expression of NOS1 protein]PMID:30482226
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