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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 61936
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Slc22a2
Name: solute carrier family 22 member 2
Acc ID: CHEBI:3699
Term: cimetidine
Definition: A member of the class of guanidines that consists of guanidine carrying a methyl substituent at position 1, a cyano group at position 2 and a 2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl group at position 3. It is a H2-receptor antagonist that inhibits the production of acid in stomach.
Chemical ID: MESH:D002927
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Slc22a2increases transportEXP 6480464CTDSLC22A2 protein results in increased transport of CimetidinePMID:18230276
Slc22a2increases uptakeEXP 6480464CTDSLC22A2 protein results in increased uptake of CimetidinePMID:16006492
Slc22a2decreases response to substanceISOSLC22A2 (Homo sapiens)6480464CTDSLC22A2 gene polymorphism results in decreased susceptibility to CimetidinePMID:22525860
Slc22a2increases uptakeISOSLC22A2 (Homo sapiens)6480464CTDSLC22A2 protein results in increased uptake of CimetidinePMID:15496291 PMID:16006492
Slc22a2multiple interactionsISOSLC22A2 (Homo sapiens)6480464CTD1-Methyl-4-phenylpyridinium inhibits the reaction [SLC22A2 protein results in increased uptake of Cimetidine]; Cimetidine inhibits the reaction [SLC22A2 protein affects the transport of Tetraethylammonium]; Cimetidine inhibits the reaction [SLC22A2 protein polymorphism results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]; Cimetidine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]; Cimetidine inhibits the reaction [SLC22A2 protein results in increased uptake of Ethidium]; p-Aminohippuric Acid inhibits the reaction [SLC22A2 protein results in increased uptake of Cimetidine]PMID:15496291 PMID:19357179 PMID:21599003
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