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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 61928
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hif1a
Name: hypoxia inducible factor 1 subunit alpha
Acc ID: CHEBI:9150
Term: simvastatin
Definition: A member of the class of hexahydronaphthalenes that is lovastatin in which the 2-methylbutyrate ester moiety has been replaced by a 2,2-dimethylbutyrate ester group. It is used as a cholesterol-lowering and anti-cardiovascular disease drug.
Chemical ID: MESH:D019821
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hif1adecreases expressionEXP 6480464CTDSimvastatin results in decreased expression of HIF1A mRNAPMID:21844074
Hif1aincreases expressionISOHIF1A (Homo sapiens)6480464CTDSimvastatin results in increased expression of HIF1A proteinPMID:18356691
Hif1amultiple interactionsISOHIF1A (Homo sapiens)6480464CTDHIF1A mutant form inhibits the reaction [Simvastatin results in increased expression of VEGFA mRNA]PMID:18356691
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