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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 61817
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Col1a1
Name: collagen type I alpha 1 chain
Acc ID: CHEBI:46195
Term: paracetamol
Definition: A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
Chemical ID: MESH:D000082
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Col1a1decreases expressionEXP 6480464CTDAcetaminophen results in decreased expression of COL1A1 mRNAPMID:33387578
Col1a1decreases expressionISOCOL1A1 (Homo sapiens)6480464CTDAcetaminophen results in decreased expression of COL1A1 mRNAPMID:21420995
Col1a1increases expressionISOCol1a1 (Mus musculus)6480464CTDAcetaminophen results in increased expression of COL1A1 mRNAPMID:28286204 PMID:29355602
Col1a1multiple interactionsISOCol1a1 (Mus musculus)6480464CTD[Clofibrate co-treated with Acetaminophen] affects the expression of COL1A1 mRNA; andrographolide inhibits the reaction [Acetaminophen results in increased expression of COL1A1 mRNA]; EGR1 protein affects the reaction [Acetaminophen results in increased expression of COL1A1 mRNA]; NFE2L2 gene mutant form promotes the reaction [Acetaminophen results in increased expression of COL1A1 mRNA]; PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of COL1A1 mRNA]PMID:17585979 PMID:28286204 PMID:29355602
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