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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 61817
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Col1a1
Name: collagen type I alpha 1 chain
Acc ID: CHEBI:32016
Term: pirfenidone
Definition: A pyridone that is 2-pyridone substituted at positions 1 and 5 by phenyl and methyl groups respectively. An anti-inflammatory drug used for the treatment of idiopathic pulmonary fibrosis.
Chemical ID: MESH:C093844
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Col1a1multiple interactionsEXP 6480464CTDpirfenidone inhibits the reaction [Dimethylnitrosamine results in increased expression of COL1A1 mRNA]PMID:15571005
Col1a1decreases expressionISOCOL1A1 (Homo sapiens)6480464CTDpirfenidone results in decreased expression of COL1A1 mRNAPMID:27235791
Col1a1multiple interactionsISOCol1a1 (Mus musculus)6480464CTDpirfenidone inhibits the reaction [Paraquat results in increased expression of COL1A1 mRNA]PMID:29273418
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