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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 61817
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Col1a1
Name: collagen type I alpha 1 chain
Acc ID: CHEBI:27470
Term: folic acid
Definition: An N-acyl-amino acid that is a form of the water-soluble vitamin B9. Its biologically active forms (tetrahydrofolate and others) are essential for nucleotide biosynthesis and homocysteine remethylation.
Chemical ID: MESH:D005492
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Col1a1increases expressionISOCol1a1 (Mus musculus)6480464CTDFolic Acid results in increased expression of COL1A1 mRNA; Folic Acid results in increased expression of COL1A1 proteinPMID:34619300
Col1a1multiple interactionsISOCol1a1 (Mus musculus)6480464CTD[Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of COL1A1 mRNA; [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of COL1A1 mRNAPMID:20548288 PMID:20938992 PMID:23439872
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