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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 61817
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Col1a1
Name: collagen type I alpha 1 chain
Acc ID: CHEBI:27300
Term: vitamin D
Definition: Any member of a group of fat-soluble hydroxy seco-steroids that exhibit biological activity against vitamin D deficiency. Vitamin D can be obtained from sun exposure, food and supplements and is biologically inactive and converted into the biologically active calcitriol via double hydroxylation in the body.
Chemical ID: MESH:D014807
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Col1a1multiple interactionsISOCol1a1 (Mus musculus)6480464CTDVitamin D inhibits the reaction [Carbon Tetrachloride results in increased expression of COL1A1 mRNA]PMID:33309619
Col1a1multiple interactionsISOCOL1A1 (Homo sapiens)6480464CTDVitamin D inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]PMID:33309619
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