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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 61817
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Col1a1
Name: collagen type I alpha 1 chain
Acc ID: CHEBI:16755
Term: chenodeoxycholic acid
Definition: A dihydroxy-5beta-cholanic acid that is (5beta)-cholan-24-oic acid substituted by hydroxy groups at positions 3 and 7 respectively.
Chemical ID: MESH:D002635
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Col1a1decreases expressionEXP 6480464CTDChenodeoxycholic Acid results in decreased expression of COL1A1 mRNAPMID:15980055
Col1a1multiple interactionsISOCol1a1 (Mus musculus)6480464CTDChenodeoxycholic Acid inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of COL1A1 mRNA]PMID:27773935
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