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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3952
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Vcam1
Name: vascular cell adhesion molecule 1
Acc ID: CHEBI:9150
Term: simvastatin
Definition: A member of the class of hexahydronaphthalenes that is lovastatin in which the 2-methylbutyrate ester moiety has been replaced by a 2,2-dimethylbutyrate ester group. It is used as a cholesterol-lowering and anti-cardiovascular disease drug.
Chemical ID: MESH:D019821
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Vcam1decreases expressionEXP 6480464CTDSimvastatin results in decreased expression of VCAM1 mRNA; Simvastatin results in decreased expression of VCAM1 proteinPMID:18309148
Vcam1decreases expressionISOVcam1 (Mus musculus)6480464CTDSimvastatin results in decreased expression of VCAM1 proteinPMID:17169357
Vcam1decreases expressionISOVCAM1 (Homo sapiens)6480464CTDSimvastatin results in decreased expression of VCAM1 mRNA; Simvastatin results in decreased expression of VCAM1 protein; Simvastatin results in decreased expression of VCAM1 protein modified formPMID:14602771 PMID:21874229 PMID:22245985
Vcam1multiple interactionsISOVCAM1 (Homo sapiens)6480464CTDMevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [CD40LG results in increased expression of VCAM1 mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased expression of VCAM1 mRNA]]; Simvastatin inhibits the reaction [CD40LG results in increased expression of VCAM1 mRNA]; Simvastatin inhibits the reaction [TNF results in increased expression of VCAM1 mRNA]; Simvastatin promotes the reaction [[Ethinyl Estradiol co-treated with Desogestrel] results in decreased expression of VCAM1 protein]; Simvastatin promotes the reaction [ethinyl estradiol-desogestrel combination results in decreased expression of VCAM1 protein]; Simvastatin promotes the reaction [IL1B protein results in increased expression of VCAM1 protein]; Vitamin E inhibits the reaction [Simvastatin results in decreased expression of VCAM1 protein modified form]PMID:10946302 PMID:14602771 PMID:15234187 PMID:17105841 PMID:18269829 PMID:20863785
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