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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3932
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ucp2
Name: uncoupling protein 2
Acc ID: CHEBI:47612
Term: bezafibrate
Definition: A monocarboxylic acid amide obtained by the formal condensation of the carboxy group of 4-chlorobenzoic acid with the amino group of 2-[4-(2-aminoethyl)phenoxy]-2-methylpropanoic acid. Benafibrate is used for the treatment of hyperlipidaemia.
Chemical ID: MESH:D001629
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ucp2affects expressionEXP 6480464CTDBezafibrate affects the expression of UCP2 mRNAPMID:10933891
Ucp2increases expressionEXP 6480464CTDBezafibrate results in increased expression of UCP2 mRNAPMID:11473052 PMID:12588052
Ucp2multiple interactionsEXP 6480464CTD[Bezafibrate binds to and results in increased activity of PPARA protein] which results in increased expression of UCP2 mRNA; Triiodothyronine promotes the reaction [Bezafibrate results in increased expression of UCP2 mRNA]PMID:11341955 PMID:12588052
Ucp2increases expressionISOUcp2 (Mus musculus)6480464CTDBezafibrate results in increased expression of UCP2 mRNAPMID:11056218
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