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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3931
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ucp1
Name: uncoupling protein 1
Acc ID: CHEBI:47495
Term: N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide
Definition: A member of the class of isoquinolines that is the sulfonamide obtained by formal condensation of the sulfo group of isoquinoline-5-sulfonic acid with the primary amino group of N(1)-[3-(4-bromophenyl)prop-2-en-1-yl]ethane-1,2-diamine. It is a protein kinase A inhibitor.
Chemical ID: MESH:C063509
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ucp1multiple interactionsEXP 6480464CTDN-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Bucladesine results in increased expression of UCP1 mRNA]PMID:12414803
Ucp1multiple interactionsISOUcp1 (Mus musculus)6480464CTDN-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [[licarin A affects the susceptibility to [INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone]] which results in increased expression of UCP1 protein]PMID:29288687
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