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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3928
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Uchl1
Name: ubiquitin C-terminal hydrolase L1
Acc ID: CHEBI:29678
Term: sodium arsenite
Definition: An inoganic sodium salt with formula with formula NaAsO2.
Chemical ID: MESH:C017947
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Uchl1decreases expressionEXP 6480464CTDsodium arsenite results in decreased expression of UCHL1 proteinPMID:29459688
Uchl1decreases expressionISOUchl1 (Mus musculus)6480464CTDsodium arsenite results in decreased expression of UCHL1 mRNAPMID:37682722
Uchl1decreases methylationISOUCHL1 (Homo sapiens)6480464CTDsodium arsenite results in decreased methylation of UCHL1 genePMID:25199682
Uchl1increases expressionISOUCHL1 (Homo sapiens)6480464CTDsodium arsenite results in increased expression of UCHL1 mRNAPMID:21281968 PMID:38568856
Uchl1increases expressionISOUchl1 (Mus musculus)6480464CTDsodium arsenite results in increased expression of UCHL1 mRNAPMID:16014739 PMID:25270620
Uchl1multiple interactionsISOUCHL1 (Homo sapiens)6480464CTD[[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased abundance of Manganese]] results in increased expression of UCHL1 mRNA; [sodium arsenite results in increased abundance of Arsenic] which results in increased expression of UCHL1 mRNAPMID:39836092
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