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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3898
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tpm1
Name: tropomyosin 1
Acc ID: CHEBI:16469
Term: 17beta-estradiol
Definition: The 17beta-isomer of estradiol.
Chemical ID: MESH:D004958
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tpm1decreases expressionISOTpm1 (Mus musculus)6480464CTDEstradiol results in decreased expression of TPM1 mRNAPMID:19484750
Tpm1increases expressionISOTPM1 (Homo sapiens)6480464CTDEstradiol results in increased expression of TPM1 mRNAPMID:24758408 PMID:31614463
Tpm1multiple interactionsISOTPM1 (Homo sapiens)6480464CTD[Estradiol co-treated with TGFB1 protein] results in increased expression of TPM1 mRNA; EGF protein promotes the reaction [Estradiol results in increased expression of TPM1 mRNA]PMID:24758408 PMID:30165855
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