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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3895
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tph1
Name: tryptophan hydroxylase 1
Acc ID: CHEBI:27385
Term: tetrachloromethane
Definition: A chlorocarbon that is methane in which all the hydrogens have been replaced by chloro groups.
Chemical ID: MESH:D002251
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tph1increases expressionISOTPH1 (Homo sapiens)6480464CTDCarbon Tetrachloride results in increased expression of TPH1 mRNA; Carbon Tetrachloride results in increased expression of TPH1 proteinPMID:35202708
Tph1increases expressionISOTph1 (Mus musculus)6480464CTDCarbon Tetrachloride results in increased expression of TPH1 mRNA; Carbon Tetrachloride results in increased expression of TPH1 proteinPMID:35202708
Tph1multiple interactionsISOTPH1 (Homo sapiens)6480464CTDsarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased expression of TPH1 mRNA]; sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased expression of TPH1 protein]PMID:35202708
Tph1multiple interactionsISOTph1 (Mus musculus)6480464CTD[sarpogrelate co-treated with Carbidopa] inhibits the reaction [Carbon Tetrachloride results in increased expression of TPH1 mRNA]; [sarpogrelate co-treated with Carbidopa] inhibits the reaction [Carbon Tetrachloride results in increased expression of TPH1 protein]; sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased expression of TPH1 mRNA]; sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased expression of TPH1 protein]PMID:35202708
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