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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3889
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tp53
Name: tumor protein p53
Acc ID: CHEBI:65408
Term: andrographolide
Definition: A labdane diterpenoid isolated from the leaves and roots of Andrographis paniculata that exhibits anti-HIV, anti-inflammatory and antineoplastic properties.
Chemical ID: MESH:C030419
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tp53increases expressionISOTP53 (Homo sapiens)6480464CTDandrographolide results in increased expression of TP53PMID:19097688
Tp53multiple interactionsISOTP53 (Homo sapiens)6480464CTDandrographolide results in increased expression of and results in increased phosphorylation of TP53 protein; Fluorouracil promotes the reaction [andrographolide results in increased expression of TP53]PMID:18619950 PMID:19097688
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