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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3889
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tp53
Name: tumor protein p53
Acc ID: CHEBI:5847
Term: ICI D1694
Definition: A N-acyl-amino acid that has formula C21H22N4O6S.
Chemical ID: MESH:C068874
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tp53affects response to substanceISOTP53 (Homo sapiens)6480464CTDTP53 protein affects the susceptibility to raltitrexedPMID:17339891
Tp53multiple interactionsISOTP53 (Homo sapiens)6480464CTDTP53 protein affects the reaction [raltitrexed results in increased expression of FAS protein]; TP53 protein inhibits the reaction [raltitrexed results in increased phosphorylation of STAT1 protein]PMID:15161716 PMID:16204068
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