Gene Chemical Interaction Report - Rat Genome Database

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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID:	3876
Species:	Rattus norvegicus
RGD Object:	Gene
Symbol:	Tnf
Name:	tumor necrosis factor

Acc ID:	CHEBI:78741
Term:	oxidopamine
Definition:	A benzenetriol that is phenethylamine in which the hydrogens at positions 2, 4, and 5 on the phenyl ring are replaced by hydroxy groups. It occurs naturally in human urine, but is also produced as a metabolite of the drug DOPA (used for the treatment of Parkinson's disease).
Chemical ID:	MESH:D016627

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Object Symbol	Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
Tnf	increases expression	EXP		6480464	CTD	Oxidopamine results in increased expression of TNF protein	PMID:22842585 PMID:34302886
Tnf	multiple interactions	EXP		6480464	CTD	Resveratrol inhibits the reaction [Oxidopamine results in increased expression of TNF protein]; Rosiglitazone inhibits the reaction [Oxidopamine results in increased expression of TNF protein]	PMID:22842585 PMID:34302886
Tnf	increases expression	ISO	Tnf (Mus musculus)	6480464	CTD	Oxidopamine results in increased expression of TNF protein	PMID:29054324
Tnf	multiple interactions	ISO	Tnf (Mus musculus)	6480464	CTD	chrysin inhibits the reaction [Oxidopamine results in increased expression of TNF protein]	PMID:29054324

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