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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3876
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tnf
Name: tumor necrosis factor
Acc ID: CHEBI:72637
Term: (4Z,7Z,10Z,13Z,15E,19Z)-17-hydroxydocosahexaenoic acid
Definition: A hydroxydocosahexaenoic acid that consists of 4Z,7Z,10Z,13Z,15E,19Z-docosahexaenoic acid bearing an additional 17-hydroxy substituent.
Chemical ID: MESH:C062894
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tnfdecreases secretionISOTnf (Mus musculus)6480464CTD17-hydroxy-4,7,10,13,15,19-docosahexaenoic acid results in decreased secretion of TNF proteinPMID:17056761
Tnfmultiple interactionsISOTnf (Mus musculus)6480464CTD17-hydroxy-4,7,10,13,15,19-docosahexaenoic acid inhibits the reaction [Dextran Sulfate results in increased expression of TNF protein]; 17-hydroxy-4,7,10,13,15,19-docosahexaenoic acid inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]PMID:21724996
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