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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3876
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tnf
Name: tumor necrosis factor
Acc ID: CHEBI:35189
Term: sesquiterpene
Definition: A C15 terpene.
Chemical ID: MESH:D012717
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tnfmultiple interactionsISOTNF (Homo sapiens)6480464CTDSesquiterpenes analog inhibits the reaction [TNF protein results in increased expression of CXCL8 mRNA]; Sesquiterpenes analog inhibits the reaction [TNF protein results in increased expression of IL6 mRNA]; Sesquiterpenes analog inhibits the reaction [TNF protein results in increased expression of NFKBIA protein modified form]; Sesquiterpenes analog inhibits the reaction [TNF protein results in increased expression of RELA protein modified form]; Sesquiterpenes analog inhibits the reaction [TNF protein results in increased expression of TNF mRNA]PMID:30672058
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