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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3876
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tnf
Name: tumor necrosis factor
Acc ID: CHEBI:28179
Term: benzamide
Definition: An aromatic amide that consists of benzene bearing a single carboxamido substituent. The parent of the class of benzamides.
Chemical ID: MESH:C037689
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tnfdecreases expressionEXP 6480464CTDbenzamide results in decreased expression of TNF mRNAPMID:12411406
Tnfmultiple interactionsEXP 6480464CTDbenzamide inhibits the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of TNF mRNA]PMID:12411406
Tnfmultiple interactionsISOTNF (Homo sapiens)6480464CTDbenzamide inhibits the reaction [TNF protein promotes the reaction [[PARP1 protein binds to MOR enhancer mutant form] which results in increased expression of MOR mRNA]]PMID:19447888
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