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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3876
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tnf
Name: tumor necrosis factor
Acc ID: CHEBI:25549
Term: nitrites
Definition: null
Chemical ID: MESH:D009573
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tnfincreases abundanceEXP 6480464CTDTNF protein results in increased abundance of NitritesPMID:16140881
Tnfmultiple interactionsEXP 6480464CTD[Carmustine co-treated with 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid] inhibits the reaction [[TNF protein results in increased activity of NOS2 protein] which results in increased chemical synthesis of Nitrites]; [TNF protein results in increased activity of NOS2 protein] which results in increased chemical synthesis of Nitrites; IFNG protein promotes the reaction [[TNF protein results in increased activity of NOS2 protein] which results in increased chemical synthesis of Nitrites]; Nitrites inhibits the reaction [[TNF protein results in increased activity of NOS2 protein] which results in increased chemical synthesis of 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid]; Nitrites inhibits the reaction [[TNF protein results in increased activity of NOS2 protein] which results in increased chemical synthesis of Amobarbital]; Nitrites inhibits the reaction [[TNF protein results in increased activity of NOS2 protein] which results in increased chemical synthesis of Buthionine Sulfoximine]; Nitrites inhibits the reaction [[TNF protein results in increased activity of NOS2 protein] which results in increased chemical synthesis of Carmustine]; Nitrites inhibits the reaction [[TNF protein results in increased activity of NOS2 protein] which results in increased chemical synthesis of Deferoxamine]; Nitrites inhibits the reaction [[TNF protein results in increased activity of NOS2 protein] which results in increased chemical synthesis of diethyl maleate]; Nitrites inhibits the reaction [[TNF protein results in increased activity of NOS2 protein] which results in increased chemical synthesis of Rotenone]; Triglycerides inhibits the reaction [TNF protein affects the abundance of Nitrites]PMID:16140881 PMID:7532384
Tnfmultiple interactionsISOTnf (Mus musculus)6480464CTD5-nitro-2-(3-phenylpropylamino)benzoic acid inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased chemical synthesis of Nitrites]; [TNF protein co-treated with IFNG protein] results in increased chemical synthesis of Nitrites; IL4 protein inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased chemical synthesis of Nitrites]; TNF protein promotes the reaction [Endotoxins results in increased abundance of Nitrites]PMID:15659313 PMID:9918806
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