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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3876
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tnf
Name: tumor necrosis factor
Acc ID: CHEBI:16794
Term: scopolamine
Definition: A tropane alkaloid that is the (S)-tropic acid ester of 6beta,7beta-epoxy-1alphaH,5alphaH-tropan-3alpha-ol.
Chemical ID: MESH:D012601
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tnfincreases expressionEXP 6480464CTDScopolamine results in increased expression of TNF mRNAPMID:21161262
Tnfincreases expressionISOTnf (Mus musculus)6480464CTDScopolamine results in increased expression of TNF mRNA; Scopolamine results in increased expression of TNF proteinPMID:18357464 PMID:19182383 PMID:19426756 PMID:31077737
Tnfmultiple interactionsISOTnf (Mus musculus)6480464CTDacanthoside B inhibits the reaction [Scopolamine results in increased expression of TNF protein]; mangiferin inhibits the reaction [Scopolamine results in increased expression of TNF protein]; Tacrine inhibits the reaction [Scopolamine results in increased expression of TNF protein]; timosaponin AIII inhibits the reaction [Scopolamine results in increased expression of TNF protein]PMID:19182383 PMID:19426756 PMID:31077737
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