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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3876
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tnf
Name: tumor necrosis factor
Acc ID: CHEBI:146195
Term: 3-acetyldeoxynivalenol
Definition: A trichothecene mycotoxin that is deoxynivalenol acetylated on the oxygen at C-3. A skin and eye irritant, along with its 15-acetyl regioisomer and its parent deoxynivalenol it is considered among the most commonly and widely distributed cereal contaminants.
Chemical ID: MESH:C043247
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tnfincreases expressionISOTnf (Mus musculus)6480464CTD3-acetyldeoxynivalenol results in increased expression of TNF mRNAPMID:24793808 PMID:35413383
Tnfmultiple interactionsISOTnf (Mus musculus)6480464CTD3-acetyldeoxynivalenol results in increased expression of and results in increased secretion of TNF protein; 4-phenylbutyric acid inhibits the reaction [3-acetyldeoxynivalenol results in increased expression of and results in increased secretion of TNF protein]; 4-phenylbutyric acid inhibits the reaction [3-acetyldeoxynivalenol results in increased expression of TNF mRNA]PMID:35413383
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