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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3853
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Th
Name: tyrosine hydroxylase
Acc ID: CHEBI:5353
Term: ginkgetin
Definition: A biflavonoid that is the 7,4'-dimethyl ether derivative of amentoflavone. Isolated from Ginkgo biloba and Dioon, it exhibits anti-HSV-1, antineoplastic and inhibitory activities towards arachidonate 5-lipoxygenase and cyclooxygenase 2.
Chemical ID: MESH:C077458
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Thmultiple interactionsISOTh (Mus musculus)6480464CTDginkgetin inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of TH protein]PMID:25968939
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