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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3853
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Th
Name: tyrosine hydroxylase
Acc ID: CHEBI:5118
Term: fluoxetine
Definition: A racemate comprising equimolar amounts of (R)- and (S)-fluoxetine. A selective serotonin reuptake inhibitor (SSRI), it is used (generally as the hydrochloride salt) for the treatment of depression (and the depressive phase of bipolar disorder), bullimia nervosa, and obsessive-compulsive disorder.
Chemical ID: MESH:D005473
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Thaffects expressionEXP 6480464CTDFluoxetine affects the expression of THPMID:26475043
Thdecreases expressionEXP 6480464CTDFluoxetine results in decreased expression of TH mRNAPMID:15936043
Thincreases expressionEXP 6480464CTDFluoxetine results in increased expression of TH mRNAPMID:1351783 PMID:20626387
Thdecreases expressionISOTh (Mus musculus)6480464CTDFluoxetine results in decreased expression of TH mRNAPMID:20857517
Thincreases expressionISOTh (Mus musculus)6480464CTDFluoxetine results in increased expression of TH mRNAPMID:20374287
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