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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3774
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Stat5b
Name: signal transducer and activator of transcription 5B
Acc ID: CHEBI:15767
Term: dichloromethane
Definition: A member of the class of chloromethanes that is methane in which two of the hydrogens have been replaced by chlorine. A dense, non-flammible colourless liquid at room temperature (b.p. 40degreeC, d = 1.33) which is immiscible with water, it is widely used as a solvent, a paint stripper, and for the removal of caffeine from coffee and tea.
Chemical ID: MESH:D008752
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Stat5bdecreases expressionISOStat5b (Mus musculus)6480464CTDMethylene Chloride results in decreased expression of STAT5B mRNAPMID:28392392
Stat5bincreases activityISOStat5b (Mus musculus)6480464CTDMethylene Chloride results in increased activity of STAT5B proteinPMID:30114225
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