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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3772
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Stat3
Name: signal transducer and activator of transcription 3
Acc ID: CHEBI:68610
Term: linagliptin
Definition: A xanthine that is 7H-xanthine bearing (4-methylquinazolin-2-yl)methyl, methyl, but-2-yn-1-yl and 3-aminopiperidin-1-yl substituents at positions 1, 3, 7 and 8 respectively (the R-enantiomer). Used for treatment of type II diabetes.
Chemical ID: MESH:D000069476
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Stat3multiple interactionsEXP 6480464CTDLinagliptin inhibits the reaction [Acetic Acid results in increased phosphorylation of STAT3 protein]PMID:35122774
Stat3multiple interactionsISOStat3 (Mus musculus)6480464CTDLinagliptin inhibits the reaction [Cuprizone results in increased expression of STAT3 protein modified form]PMID:29864483
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