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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3771
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Stat1
Name: signal transducer and activator of transcription 1
Acc ID: CHEBI:6706
Term: Mecamylamine
Definition: A primary aliphatic amine that has formula C11H21N.
Chemical ID: MESH:D008464
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Stat1multiple interactionsISOSTAT1 (Homo sapiens)6480464CTDMecamylamine inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased activity of STAT1 protein]; Mecamylamine inhibits the reaction [N'-nitrosonornicotine results in increased activity of STAT1 protein]; Mecamylamine inhibits the reaction [N'-nitrosonornicotine results in increased expression of STAT1 mRNA]PMID:16582591 PMID:16835749
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