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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3771
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Stat1
Name: signal transducer and activator of transcription 1
Acc ID: CHEBI:16469
Term: 17beta-estradiol
Definition: The 17beta-isomer of estradiol.
Chemical ID: MESH:D004958
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Stat1increases expressionEXP 6480464CTDEstradiol results in increased expression of STAT1 mRNAPMID:32145629 PMID:35192832
Stat1multiple interactionsEXP 6480464CTD[estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of STAT1 mRNAPMID:32741896
Stat1decreases expressionISOSTAT1 (Homo sapiens)6480464CTDEstradiol results in decreased expression of STAT1 mRNAPMID:23373633
Stat1increases expressionISOSTAT1 (Homo sapiens)6480464CTDEstradiol results in increased expression of STAT1 mRNA; Estradiol results in increased expression of STAT1 proteinPMID:16514628 PMID:19619570 PMID:21185374
Stat1increases phosphorylationISOSTAT1 (Homo sapiens)6480464CTDEstradiol results in increased phosphorylation of STAT1 proteinPMID:21185374
Stat1multiple interactionsISOSTAT1 (Homo sapiens)6480464CTD[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of STAT1 mRNAPMID:19619570
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