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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3770
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Star
Name: steroidogenic acute regulatory protein
Acc ID: CHEBI:76591
Term: (25R)-cholest-5-ene-3beta,26-diol
Definition: A 26-hydroxycholesterol in which the 25-position has R-configuration.
Chemical ID: MESH:C076996
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Starincreases abundanceEXP 6480464CTDSTAR protein results in increased abundance of 27-hydroxycholesterolPMID:12368294
Starincreases abundanceISOSTAR (Homo sapiens)6480464CTDSTAR protein results in increased abundance of 27-hydroxycholesterolPMID:15863358
Starincreases expressionISOStar (Mus musculus)6480464CTD27-hydroxycholesterol results in increased expression of STAR mRNA; 27-hydroxycholesterol results in increased expression of STAR proteinPMID:23362264
Starincreases expressionISOSTAR (Homo sapiens)6480464CTD27-hydroxycholesterol results in increased expression of STAR proteinPMID:15863358
Starmultiple interactionsISOStar (Mus musculus)6480464CTD27-hydroxycholesterol promotes the reaction [STAR protein promotes the reaction [[Bucladesine co-treated with APOA1 protein] results in increased secretion of Cholesterol]]; LIPE protein promotes the reaction [27-hydroxycholesterol results in increased expression of STAR mRNA]; LIPE protein promotes the reaction [27-hydroxycholesterol results in increased expression of STAR protein]PMID:20083572 PMID:23362264
Starmultiple interactionsISOSTAR (Homo sapiens)6480464CTD27-hydroxycholesterol promotes the reaction [NR5A1 protein results in increased expression of STAR protein]PMID:9804848
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