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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3757
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Srd5a1
Name: steroid 5 alpha-reductase 1
Acc ID: CHEBI:35549
Term: perfluorooctanoic acid
Definition: A fluoroalkanoic acid that is perfluorinated octanoic acid.
Chemical ID: MESH:C023036
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Srd5a1decreases activityEXP 6480464CTDperfluorooctanoic acid results in decreased activity of SRD5A1 proteinPMID:28535922 PMID:38574835
Srd5a1decreases expressionEXP 6480464CTDperfluorooctanoic acid results in decreased expression of SRD5A1 mRNA; perfluorooctanoic acid results in decreased expression of SRD5A1 proteinPMID:19162173 PMID:34958885
Srd5a1decreases expressionISOSrd5a1 (Mus musculus)6480464CTDperfluorooctanoic acid results in decreased expression of SRD5A1 mRNAPMID:17681415 PMID:23626681
Srd5a1multiple interactionsISOSrd5a1 (Mus musculus)6480464CTD[perfluorooctanoic acid co-treated with Dietary Fats, Unsaturated] results in decreased expression of SRD5A1 mRNAPMID:23626681
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