GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Sp1 | multiple interactions | ISO | SP1 (Homo sapiens) | 6480464 | CTD | [nickel chloride co-treated with Metformin] promotes the reaction [SP1 protein binds to GSTM2 promoter]; [nickel chloride co-treated with Metformin] results in increased expression of SP1 protein; nickel chloride inhibits the reaction [SP1 protein binds to CTH promoter]; nickel chloride inhibits the reaction [SP1 protein results in increased expression of CTH protein]; nickel chloride promotes the reaction [SP1 protein binds to TGFB1 promoter]; nickel chloride promotes the reaction [SP1 protein results in increased expression of TGFB1 protein]; sodium bisulfide inhibits the reaction [nickel chloride inhibits the reaction [SP1 protein binds to CTH promoter]]; sodium bisulfide inhibits the reaction [nickel chloride promotes the reaction [SP1 protein binds to TGFB1 promoter]] | PMID:30055191 PMID:38050843 | | ||||||||||||||||||||||
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