Gene Chemical Interaction Report - Rat Genome Database

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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID:	3738
Species:	Rattus norvegicus
RGD Object:	Gene
Symbol:	Sp1
Name:	Sp1 transcription factor

Acc ID:	CHEBI:27568
Term:	selenium atom
Definition:	A chalcogen that has formula Se.
Chemical ID:	MESH:D012643

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Object Symbol	Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
Sp1	multiple interactions	EXP		6480464	CTD	[Sodium Selenite results in increased abundance of Selenium] inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of SP1 mRNA]; [Sodium Selenite results in increased abundance of Selenium] inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of SP1 protein]; [Sodium Selenite results in increased abundance of Selenium] which results in increased expression of SP1 protein	PMID:35384129
Sp1	multiple interactions	ISO	SP1 (Homo sapiens)	6480464	CTD	[Sodium Selenite results in increased abundance of Selenium] inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of SP1 mRNA]; [Sodium Selenite results in increased abundance of Selenium] inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of SP1 protein]	PMID:35384129

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