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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3732
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Sod2
Name: superoxide dismutase 2
Acc ID: CHEBI:46979
Term: N-acetylsphingosine
Definition: A N-acylsphingosine that has an acetamido group at position 2.
Chemical ID: MESH:C064769
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sod2increases expressionEXP 6480464CTDN-acetylsphingosine results in increased expression of SOD2 mRNA; N-acetylsphingosine results in increased expression of SOD2 proteinPMID:10428046
Sod2increases expressionISOSOD2 (Homo sapiens)6480464CTDN-acetylsphingosine results in increased expression of SOD2 mRNA; N-acetylsphingosine results in increased expression of SOD2 proteinPMID:10428046 PMID:9535218
Sod2multiple interactionsISOSOD2 (Homo sapiens)6480464CTDAcetylcysteine inhibits the reaction [N-acetylsphingosine results in increased expression of SOD2 mRNA]; Acetylcysteine inhibits the reaction [N-acetylsphingosine results in increased expression of SOD2 protein]PMID:9535218
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