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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3731
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Sod1
Name: superoxide dismutase 1
Acc ID: CHEBI:63041
Term: manganese(II) chloride
Definition: An inorganic chloride in which manganese(II) is coordinated to two chloride ions. In its anhydrous state manganese(II) chloride is a polymeric solid, which adopts a layered cadmium chloride-like structure.
Chemical ID: MESH:C025340
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sod1multiple interactionsEXP 6480464CTD[manganese chloride results in increased abundance of Manganese] which results in decreased expression of SOD1 mRNA; [manganese chloride results in increased abundance of Manganese] which results in decreased expression of SOD1 proteinPMID:38129942
Sod1decreases activityISOSod1 (Mus musculus)6480464CTDmanganese chloride results in decreased activity of SOD1 proteinPMID:25874029
Sod1multiple interactionsISOSod1 (Mus musculus)6480464CTDHFE gene mutant form inhibits the reaction [manganese chloride results in decreased activity of SOD1 protein]PMID:25874029
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