CHEBI ONTOLOGY - ANNOTATIONS |
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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
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Term: | manganese(II) chloride |
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Accession: | CHEBI:63041
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browse the term
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Definition: | An inorganic chloride in which manganese(II) is coordinated to two chloride ions. In its anhydrous state manganese(II) chloride is a polymeric solid, which adopts a layered cadmium chloride-like structure. |
Synonyms: | exact_synonym: | manganese(2+) dichloride |
| related_synonym: | Formula=Cl2Mn; InChI=1S/2ClH.Mn/h2*1H;/q;;+2/p-2; InChIKey=GLFNIEUTAYBVOC-UHFFFAOYSA-L; Mangandichlorid; Manganese bichloride; Manganese(II) chloride (1:2); Manganous chloride; SMILES=Cl[Mn]Cl; dichlorure de manganese; manganese(II) dichloride; manganous dichloride |
| xref: | CAS:7773-01-5 |
| xref_mesh: | MESH:C025340 |
| xref: | MetaCyc:CPD0-2394; PMID:101555; PMID:146543; PMID:19801673; PMID:3143594; PMID:4476198; PMID:4771199; PMID:98204; Reaxys:8128170; Wikipedia:Manganese(II)_chloride |
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Abca5 |
ATP binding cassette subfamily A member 5 |
decreases expression |
ISO |
manganese chloride results in decreased expression of ABCA5 mRNA |
CTD |
PMID:17175027 |
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NCBI chr10:98,573,226...98,645,028
Ensembl chr10:98,576,039...98,644,938
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Abca9 |
ATP binding cassette subfamily A member 9 |
increases expression |
ISO |
manganese chloride results in increased expression of ABCA9 mRNA |
CTD |
PMID:17175027 |
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NCBI chr10:98,412,263...98,472,258
Ensembl chr10:98,412,263...98,469,799
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Abcb1a |
ATP binding cassette subfamily B member 1A |
increases expression |
EXP |
manganese chloride results in increased expression of ABCB1A mRNA |
CTD |
PMID:26745496 |
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NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
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Abcb1b |
ATP-binding cassette, subfamily B (MDR/TAP), member 1B |
increases expression |
EXP |
manganese chloride results in increased expression of ABCB1B mRNA |
CTD |
PMID:28801915 |
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NCBI chr 4:22,225,123...22,307,577
Ensembl chr 4:22,133,521...22,425,515
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Abcc2 |
ATP binding cassette subfamily C member 2 |
increases expression decreases methylation |
EXP |
manganese chloride results in increased expression of ABCC2 mRNA manganese chloride results in decreased methylation of ABCC2 gene |
CTD |
PMID:28801915 |
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NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252
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Abcc8 |
ATP binding cassette subfamily C member 8 |
multiple interactions |
ISO |
[manganese chloride results in increased abundance of Manganese] which results in increased expression of ABCC8 protein |
CTD |
PMID:32659473 |
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NCBI chr 1:102,110,708...102,191,287
Ensembl chr 1:102,110,708...102,191,287
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Abi2 |
abl-interactor 2 |
increases expression |
ISO |
manganese chloride results in increased expression of ABI2 mRNA |
CTD |
PMID:17175027 |
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NCBI chr 9:67,234,612...67,284,504
Ensembl chr 9:67,234,303...67,282,600
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Abitram |
actin binding transcription modulator |
increases expression |
EXP |
manganese chloride results in increased expression of ABITRAM mRNA |
CTD |
PMID:28801915 |
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NCBI chr 5:73,552,952...73,560,240
Ensembl chr 5:73,552,983...73,556,987
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Acap1 |
ArfGAP with coiled-coil, ankyrin repeat and PH domains 1 |
increases expression |
EXP |
manganese chloride results in increased expression of ACAP1 mRNA |
CTD |
PMID:28801915 |
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NCBI chr10:56,492,300...56,506,446
Ensembl chr10:56,492,300...56,506,446
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Ace |
angiotensin I converting enzyme |
increases expression |
EXP |
manganese chloride results in increased expression of ACE mRNA |
CTD |
PMID:28801915 |
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NCBI chr10:94,170,766...94,213,831
Ensembl chr10:94,170,766...94,187,822
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Ache |
acetylcholinesterase |
increases activity multiple interactions decreases activity increases expression |
EXP ISO |
manganese chloride results in increased activity of ACHE protein [manganese chloride results in increased abundance of Manganese] which results in decreased activity of ACHE protein; [manganese chloride results in increased abundance of Manganese] which results in increased activity of ACHE protein; [manganese chloride results in increased abundance of Manganese] which results in increased expression of ACHE mRNA alternative form manganese chloride results in decreased activity of ACHE protein [manganese chloride results in increased abundance of Manganese] promotes the reaction [Ethanol results in increased activity of ACHE protein]; [manganese chloride results in increased abundance of Manganese] which results in increased activity of ACHE protein; Ethanol promotes the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased activity of ACHE protein]; Lycopene inhibits the reaction [manganese chloride results in increased activity of ACHE protein]; Silymarin inhibits the reaction [manganese chloride results in decreased activity of ACHE protein]; Silymarin inhibits the reaction [manganese chloride results in increased activity of ACHE protein]; Silymarin inhibits the reaction [manganese chloride results in increased expression of ACHE mRNA] |
CTD |
PMID:20503066 PMID:22033861 PMID:22154916 PMID:22192907 PMID:30738988 PMID:30844427 PMID:32445656 PMID:33314588 |
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NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
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Aco1 |
aconitase 1 |
increases activity |
EXP |
manganese chloride results in increased activity of ACO1 protein |
CTD |
PMID:15893546 PMID:16545456 PMID:16568477 |
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NCBI chr 5:56,425,076...56,481,218
Ensembl chr 5:56,425,024...56,481,218
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Aco2 |
aconitase 2 |
multiple interactions decreases activity decreases expression |
ISO EXP |
ferric ammonium citrate inhibits the reaction [manganese chloride results in decreased activity of ACO2 protein] Iron inhibits the reaction [manganese chloride results in decreased activity of ACO2 protein] manganese chloride results in decreased expression of ACO2 mRNA; manganese chloride results in decreased expression of ACO2 protein |
CTD |
PMID:9675333 PMID:16625280 |
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NCBI chr 7:123,102,493...123,145,608
Ensembl chr 7:123,102,468...123,145,635
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Acot2 |
acyl-CoA thioesterase 2 |
increases expression |
EXP |
manganese chloride results in increased expression of ACOT2 mRNA |
CTD |
PMID:28801915 |
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NCBI chr 6:107,460,596...107,468,324
Ensembl chr 6:107,460,668...107,467,487
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Acp5 |
acid phosphatase 5, tartrate resistant |
increases expression increases methylation |
EXP |
manganese chloride results in increased expression of ACP5 mRNA manganese chloride results in increased methylation of ACP5 gene |
CTD |
PMID:22281203 PMID:28801915 |
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NCBI chr 8:23,142,733...23,149,067
Ensembl chr 8:23,142,734...23,148,396
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Acr |
acrosin |
increases expression |
EXP |
manganese chloride results in increased expression of ACR mRNA |
CTD |
PMID:28801915 |
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NCBI chr 7:130,541,320...130,548,356
Ensembl chr 7:130,542,202...130,548,356
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Acsl3 |
acyl-CoA synthetase long-chain family member 3 |
decreases expression |
ISO |
manganese chloride results in decreased expression of ACSL3 mRNA |
CTD |
PMID:15295902 |
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NCBI chr 9:84,569,601...84,593,565
Ensembl chr 9:84,569,597...84,593,565
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Acss2 |
acyl-CoA synthetase short-chain family member 2 |
decreases expression |
EXP |
manganese chloride results in decreased expression of ACSS2 mRNA |
CTD |
PMID:28801915 |
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NCBI chr 3:151,032,925...151,075,856
Ensembl chr 3:151,032,952...151,075,856
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Acta1 |
actin, alpha 1, skeletal muscle |
decreases expression |
EXP |
manganese chloride results in decreased expression of ACTA1 mRNA |
CTD |
PMID:26745496 |
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NCBI chr19:56,674,072...56,677,084
Ensembl chr19:56,674,074...56,677,084
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Acta2 |
actin alpha 2, smooth muscle |
increases expression |
EXP |
manganese chloride results in increased expression of ACTA2 mRNA |
CTD |
PMID:28801915 |
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NCBI chr 1:252,537,614...252,550,394
Ensembl chr 1:252,537,615...252,550,394
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Actb |
actin, beta |
decreases expression increases expression |
ISO |
manganese chloride results in decreased expression of ACTB protein manganese chloride results in increased expression of ACTB mRNA |
CTD |
PMID:20452446 |
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NCBI chr12:13,715,843...13,718,813
Ensembl chr12:13,715,843...13,718,841
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Acvrl1 |
activin A receptor like type 1 |
increases expression |
EXP |
manganese chloride results in increased expression of ACVRL1 mRNA |
CTD |
PMID:28801915 |
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NCBI chr 7:142,769,942...142,787,336
Ensembl chr 7:142,776,252...142,787,335
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Adam19 |
ADAM metallopeptidase domain 19 |
increases expression |
EXP |
manganese chloride results in increased expression of ADAM19 mRNA |
CTD |
PMID:28801915 |
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NCBI chr10:31,146,107...31,240,582
Ensembl chr10:31,146,107...31,240,582
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Adamts1 |
ADAM metallopeptidase with thrombospondin type 1 motif, 1 |
decreases expression |
EXP |
manganese chloride results in decreased expression of ADAMTS1 mRNA |
CTD |
PMID:28801915 |
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NCBI chr11:25,342,119...25,350,938
Ensembl chr11:25,342,126...25,350,974
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Adamts5 |
ADAM metallopeptidase with thrombospondin type 1 motif, 5 |
decreases expression |
EXP |
manganese chloride results in decreased expression of ADAMTS5 mRNA |
CTD |
PMID:28801915 |
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NCBI chr11:25,411,174...25,456,639
Ensembl chr11:25,410,975...25,456,836
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Adcy6 |
adenylate cyclase 6 |
increases expression |
EXP |
manganese chloride results in increased expression of ADCY6 mRNA |
CTD |
PMID:28801915 |
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NCBI chr 7:140,270,678...140,291,722
Ensembl chr 7:140,270,692...140,291,620
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Add2 |
adducin 2 |
increases expression |
EXP |
manganese chloride results in increased expression of ADD2 mRNA |
CTD |
PMID:28801915 |
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NCBI chr 4:117,691,294...117,887,556
Ensembl chr 4:117,743,710...117,882,464
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Adipoq |
adiponectin, C1Q and collagen domain containing |
increases expression |
EXP |
manganese chloride results in increased expression of ADIPOQ mRNA |
CTD |
PMID:28801915 |
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NCBI chr11:81,330,845...81,344,488
Ensembl chr11:81,330,293...81,344,488
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Adm |
adrenomedullin |
increases expression decreases expression |
ISO EXP |
manganese chloride results in increased expression of ADM mRNA manganese chloride results in decreased expression of ADM mRNA |
CTD |
PMID:17175027 PMID:28801915 |
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NCBI chr 1:175,443,189...175,447,260
Ensembl chr 1:175,445,088...175,447,259
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Adora2a |
adenosine A2a receptor |
increases expression |
EXP |
manganese chloride results in increased expression of ADORA2A mRNA |
CTD |
PMID:28801915 |
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NCBI chr20:14,265,251...14,282,873
Ensembl chr20:14,265,252...14,282,873
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Aen |
apoptosis enhancing nuclease |
increases expression |
EXP |
manganese chloride results in increased expression of AEN mRNA |
CTD |
PMID:28801915 |
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NCBI chr 1:140,584,328...140,593,749
Ensembl chr 1:140,584,380...140,593,745
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Aff1 |
AF4/FMR2 family, member 1 |
increases expression |
EXP |
manganese chloride results in increased expression of AFF1 mRNA |
CTD |
PMID:28801915 |
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NCBI chr14:7,222,883...7,384,916
Ensembl chr14:7,226,586...7,384,876
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Afmid |
arylformamidase |
increases expression |
EXP |
manganese chloride results in increased expression of AFMID mRNA |
CTD |
PMID:28801915 |
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NCBI chr10:106,828,963...106,844,314
Ensembl chr10:106,828,981...106,844,314
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Afp |
alpha-fetoprotein |
decreases expression |
EXP |
manganese chloride results in decreased expression of AFP mRNA |
CTD |
PMID:26745496 |
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NCBI chr14:19,141,755...19,159,919
Ensembl chr14:19,141,755...19,159,923
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Ahnak2 |
AHNAK nucleoprotein 2 |
increases expression |
EXP |
manganese chloride results in increased expression of AHNAK2 mRNA |
CTD |
PMID:28801915 |
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NCBI chr 6:137,335,273...137,380,219
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Aicda |
activation-induced cytidine deaminase |
increases expression |
EXP |
manganese chloride results in increased expression of AICDA mRNA |
CTD |
PMID:28801915 |
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NCBI chr 4:155,359,909...155,371,104
Ensembl chr 4:155,359,921...155,369,671
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Aif1 |
allograft inflammatory factor 1 |
increases expression |
ISO |
manganese chloride results in increased expression of AIF1 protein |
CTD |
PMID:28595911 |
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NCBI chr20:5,161,350...5,167,176
Ensembl chr20:5,161,333...5,166,448
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Akap7 |
A-kinase anchoring protein 7 |
decreases expression |
ISO |
manganese chloride results in decreased expression of AKAP7 mRNA |
CTD |
PMID:17175027 |
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NCBI chr 1:21,129,213...21,263,850
Ensembl chr 1:21,141,970...21,263,850
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Akr1b1 |
aldo-keto reductase family 1 member B |
increases expression |
EXP |
manganese chloride results in increased expression of AKR1B1 mRNA |
CTD |
PMID:22281203 |
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NCBI chr 4:61,706,866...61,720,959
Ensembl chr 4:61,706,864...61,720,956
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Akt1 |
AKT serine/threonine kinase 1 |
decreases phosphorylation multiple interactions |
EXP ISO |
manganese chloride results in decreased phosphorylation of AKT1 protein [manganese chloride results in increased abundance of Manganese] which results in decreased phosphorylation of AKT1 protein; benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in decreased phosphorylation of AKT1 protein] NTF3 protein inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in decreased phosphorylation of AKT1 protein] |
CTD |
PMID:30040983 PMID:31676349 |
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NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
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Alb |
albumin |
multiple interactions |
EXP |
[sodium arsenite co-treated with Cadmium Chloride co-treated with lead acetate co-treated with Mercuric Chloride co-treated with chromium trioxide co-treated with nickel chloride co-treated with manganese chloride co-treated with ferric chloride] results in decreased expression of ALB protein |
CTD |
PMID:17657459 |
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NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
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Aldh18a1 |
aldehyde dehydrogenase 18 family, member A1 |
increases expression |
EXP |
manganese chloride results in increased expression of ALDH18A1 mRNA |
CTD |
PMID:28801915 |
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NCBI chr 1:259,641,673...259,674,521
Ensembl chr 1:259,641,676...259,674,425 Ensembl chr 1:259,641,676...259,674,425
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Aldh1a1 |
aldehyde dehydrogenase 1 family, member A1 |
decreases expression |
EXP |
manganese chloride results in decreased expression of ALDH1A1 mRNA |
CTD |
PMID:28801915 |
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NCBI chr 1:238,222,689...238,264,381
Ensembl chr 1:238,222,521...238,264,330
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Aldh4a1 |
aldehyde dehydrogenase 4 family, member A1 |
increases expression |
EXP |
manganese chloride results in increased expression of ALDH4A1 mRNA |
CTD |
PMID:28801915 |
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NCBI chr 5:158,090,238...158,115,725
Ensembl chr 5:158,042,587...158,135,733
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Aldoa |
aldolase, fructose-bisphosphate A |
increases expression |
EXP |
manganese chloride results in increased expression of ALDOA mRNA |
CTD |
PMID:22281203 |
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NCBI chr 1:198,228,387...198,233,988
Ensembl chr 1:198,228,387...198,233,588
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Aldoc |
aldolase, fructose-bisphosphate C |
decreases expression |
EXP |
manganese chloride results in decreased expression of ALDOC mRNA |
CTD |
PMID:28801915 |
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NCBI chr10:65,586,504...65,590,093
Ensembl chr10:65,586,504...65,590,126
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Alkal1 |
ALK and LTK ligand 1 |
increases expression |
EXP |
manganese chloride results in increased expression of ALKAL1 mRNA |
CTD |
PMID:28801915 |
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NCBI chr 5:12,896,136...12,925,571
Ensembl chr 5:12,896,558...12,925,571
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Amigo3 |
adhesion molecule with Ig like domain 3 |
increases expression |
EXP |
manganese chloride results in increased expression of AMIGO3 mRNA |
CTD |
PMID:28801915 |
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NCBI chr 8:116,830,773...116,832,299
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Angpt2 |
angiopoietin 2 |
decreases expression |
EXP |
manganese chloride results in decreased expression of ANGPT2 mRNA |
CTD |
PMID:26745496 |
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NCBI chr16:75,966,480...76,016,147
Ensembl chr16:75,966,352...76,016,195
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Angptl4 |
angiopoietin-like 4 |
increases expression |
ISO |
manganese chloride results in increased expression of ANGPTL4 mRNA |
CTD |
PMID:17175027 |
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NCBI chr 7:18,627,814...18,634,043
Ensembl chr 7:18,627,808...18,634,079
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Ankrd28 |
ankyrin repeat domain 28 |
increases expression |
EXP |
manganese chloride results in increased expression of ANKRD28 mRNA |
CTD |
PMID:28801915 |
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NCBI chr16:7,816,876...7,879,023
Ensembl chr16:7,818,667...7,928,518
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Ano3 |
anoctamin 3 |
increases expression |
EXP |
manganese chloride results in increased expression of ANO3 mRNA |
CTD |
PMID:28801915 |
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NCBI chr 3:101,843,516...102,203,368
Ensembl chr 3:101,840,630...102,151,489
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Anxa3 |
annexin A3 |
decreases expression |
EXP |
manganese chloride results in decreased expression of ANXA3 mRNA |
CTD |
PMID:28801915 |
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NCBI chr14:14,371,921...14,426,503
Ensembl chr14:14,364,008...14,426,437
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Aopep |
aminopeptidase O |
decreases expression |
EXP |
manganese chloride results in decreased expression of AOPEP mRNA |
CTD |
PMID:28801915 |
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NCBI chr17:507,389...825,062
Ensembl chr17:507,377...821,582
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Ap3b2 |
adaptor related protein complex 3 subunit beta 2 |
increases expression |
ISO |
manganese chloride results in increased expression of AP3B2 mRNA |
CTD |
PMID:17175027 |
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NCBI chr 1:143,284,041...143,315,846
Ensembl chr 1:143,283,996...143,315,633
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Apbb3 |
amyloid beta precursor protein binding family B member 3 |
increases expression |
EXP |
manganese chloride results in increased expression of APBB3 mRNA |
CTD |
PMID:28801915 |
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NCBI chr18:29,497,865...29,504,995
Ensembl chr18:29,497,863...29,504,995
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Apc |
APC regulator of WNT signaling pathway |
decreases expression increases methylation |
ISO |
manganese chloride results in decreased expression of APC mRNA manganese chloride results in increased methylation of APC gene |
CTD |
PMID:27913844 |
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NCBI chr18:27,011,710...27,106,323
Ensembl chr18:27,047,382...27,105,531
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Apoa2 |
apolipoprotein A2 |
decreases expression |
EXP |
manganese chloride results in decreased expression of APOA2 mRNA |
CTD |
PMID:28801915 |
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NCBI chr13:89,596,872...89,598,805
Ensembl chr13:89,597,138...89,598,802
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Apol2 |
apolipoprotein L, 2 |
increases expression |
ISO |
manganese chloride results in increased expression of APOL2 mRNA |
CTD |
PMID:17175027 |
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NCBI chr 7:118,727,658...118,735,453
Ensembl chr 7:118,728,617...118,732,738 Ensembl chr 7:118,728,617...118,732,738
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Apold1 |
apolipoprotein L domain containing 1 |
increases expression |
EXP |
manganese chloride results in increased expression of APOLD1 mRNA |
CTD |
PMID:28801915 |
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NCBI chr 4:168,752,142...168,755,024
Ensembl chr 4:168,752,133...168,755,023
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Aqp3 |
aquaporin 3 (Gill blood group) |
decreases expression |
EXP |
manganese chloride results in decreased expression of AQP3 mRNA |
CTD |
PMID:28801915 |
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NCBI chr 5:57,423,735...57,429,252
Ensembl chr 5:57,423,734...57,429,245
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Areg |
amphiregulin |
increases expression |
EXP |
manganese chloride results in increased expression of AREG mRNA |
CTD |
PMID:28801915 |
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NCBI chr14:18,521,921...18,531,179
Ensembl chr14:18,521,930...18,531,179
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Arg1 |
arginase 1 |
increases expression increases methylation |
EXP |
manganese chloride results in increased expression of ARG1 mRNA manganese chloride results in increased methylation of ARG1 gene |
CTD |
PMID:28801915 |
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NCBI chr 1:21,525,421...21,537,872
Ensembl chr 1:21,525,421...21,537,863
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Arhgap24 |
Rho GTPase activating protein 24 |
decreases expression |
EXP |
manganese chloride results in decreased expression of ARHGAP24 mRNA |
CTD |
PMID:28801915 |
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NCBI chr14:8,383,211...8,600,526
Ensembl chr14:8,383,214...8,600,512
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Arhgdia |
Rho GDP dissociation inhibitor alpha |
decreases expression |
ISO |
manganese chloride results in decreased expression of ARHGDIA mRNA |
CTD |
PMID:17175027 |
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NCBI chr10:109,754,012...109,757,506
Ensembl chr10:109,754,004...109,757,550
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Arhgef10 |
Rho guanine nucleotide exchange factor 10 |
increases expression |
EXP |
manganese chloride results in increased expression of ARHGEF10 mRNA |
CTD |
PMID:28801915 |
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NCBI chr16:79,725,629...79,817,065
Ensembl chr16:79,725,643...79,793,619
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Arhgef16 |
Rho guanine nucleotide exchange factor 16 |
increases expression |
EXP |
manganese chloride results in increased expression of ARHGEF16 mRNA |
CTD |
PMID:28801915 |
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NCBI chr 5:171,626,450...171,649,124
Ensembl chr 5:171,624,796...171,648,563
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G |
Arhgef4 |
Rho guanine nucleotide exchange factor 4 |
increases expression increases methylation |
ISO EXP |
manganese chloride results in increased expression of ARHGEF4 mRNA manganese chloride results in increased methylation of ARHGEF4 gene |
CTD |
PMID:17175027 PMID:28801915 |
|
NCBI chr 9:41,160,562...41,305,015
Ensembl chr 9:41,295,909...41,302,501
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G |
Arhgef6 |
Rac/Cdc42 guanine nucleotide exchange factor 6 |
increases expression |
EXP |
manganese chloride results in increased expression of ARHGEF6 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr X:159,722,031...159,841,344
Ensembl chr X:159,723,866...159,841,072
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G |
Arhgef7 |
Rho guanine nucleotide exchange factor 7 |
decreases expression |
EXP |
manganese chloride results in decreased expression of ARHGEF7 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr16:83,006,732...83,117,065
Ensembl chr16:83,006,718...83,132,785
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G |
Arid3a |
AT-rich interaction domain 3A |
increases expression |
EXP |
manganese chloride results in increased expression of ARID3A mRNA |
CTD |
PMID:28801915 |
|
NCBI chr 7:12,573,604...12,602,407
Ensembl chr 7:12,574,198...12,601,674
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G |
Arl4c |
ADP ribosylation factor like GTPase 4C |
increases methylation increases expression |
EXP |
manganese chloride results in increased methylation of ARL4C gene manganese chloride results in increased expression of ARL4C mRNA |
CTD |
PMID:28801915 |
|
NCBI chr 9:95,783,651...95,787,092
Ensembl chr 9:95,786,508...95,787,094
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G |
Arnt |
aryl hydrocarbon receptor nuclear translocator |
multiple interactions |
ISO |
ARNT gene mutant form inhibits the reaction [manganese chloride results in increased secretion of VEGFA protein] |
CTD |
PMID:19263519 |
|
NCBI chr 2:196,594,178...196,651,486
Ensembl chr 2:196,594,303...196,651,179
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G |
Arntl |
aryl hydrocarbon receptor nuclear translocator-like |
decreases expression |
EXP |
manganese chloride results in decreased expression of ARNTL mRNA |
CTD |
PMID:28511934 |
|
NCBI chr 1:178,039,002...178,137,469
Ensembl chr 1:178,039,063...178,137,465
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G |
Asb5 |
ankyrin repeat and SOCS box-containing 5 |
decreases expression |
EXP |
manganese chloride results in decreased expression of ASB5 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr16:39,985,233...40,050,663
Ensembl chr16:39,985,234...40,025,401
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G |
Asns |
asparagine synthetase (glutamine-hydrolyzing) |
increases expression |
EXP |
manganese chloride results in increased expression of ASNS mRNA |
CTD |
PMID:28801915 |
|
NCBI chr 4:33,742,876...33,761,106
Ensembl chr 4:33,743,364...33,761,163
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G |
Ass1 |
argininosuccinate synthase 1 |
increases expression |
EXP |
manganese chloride results in increased expression of ASS1 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr 3:10,327,411...10,375,847
Ensembl chr 3:10,327,414...10,375,826
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G |
Aste1 |
asteroid homolog 1 |
increases expression |
EXP |
manganese chloride results in increased expression of ASTE1 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr 8:113,936,991...113,954,833
Ensembl chr 8:113,936,991...113,954,832
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G |
Atf1 |
activating transcription factor 1 |
increases phosphorylation multiple interactions |
EXP |
manganese chloride results in increased phosphorylation of ATF1 protein SB 203580 inhibits the reaction [manganese chloride results in increased phosphorylation of ATF1 protein] |
CTD |
PMID:16787641 |
|
NCBI chr 7:141,882,261...141,924,790
Ensembl chr 7:141,882,251...141,924,788
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G |
Atf2 |
activating transcription factor 2 |
increases activity increases phosphorylation |
ISO |
manganese chloride results in increased activity of ATF2 protein manganese chloride results in increased phosphorylation of ATF2 protein |
CTD |
PMID:19084589 PMID:20152896 |
|
NCBI chr 3:60,721,137...60,795,951
Ensembl chr 3:60,721,135...60,795,951
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G |
Atf4 |
activating transcription factor 4 |
multiple interactions increases expression |
EXP |
manganese chloride promotes the reaction [EIF2AK3 protein results in increased expression of ATF4 mRNA]; SNCA protein promotes the reaction [manganese chloride results in increased expression of ATF4 mRNA] manganese chloride results in increased expression of ATF4 mRNA; manganese chloride results in increased expression of ATF4 protein |
CTD |
PMID:23934647 PMID:23948121 |
|
NCBI chr 7:121,480,723...121,482,781
Ensembl chr 7:121,480,723...121,482,772
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G |
Atf6 |
activating transcription factor 6 |
decreases expression increases expression |
ISO EXP |
manganese chloride results in decreased expression of ATF6 mRNA manganese chloride results in increased expression of ATF6 protein |
CTD |
PMID:17175027 PMID:25732873 |
|
NCBI chr13:89,053,457...89,242,531
Ensembl chr13:89,055,983...89,242,443
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G |
Atm |
ATM serine/threonine kinase |
decreases expression |
ISO |
manganese chloride results in decreased expression of ATM mRNA |
CTD |
PMID:17175027 |
|
NCBI chr 8:58,015,938...58,119,973
Ensembl chr 8:58,015,940...58,120,045
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G |
Atoh8 |
atonal bHLH transcription factor 8 |
decreases expression |
EXP |
manganese chloride results in decreased expression of ATOH8 mRNA |
CTD |
PMID:26745496 PMID:28801915 |
|
NCBI chr 4:100,067,341...100,099,517
Ensembl chr 4:100,067,341...100,099,517
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G |
Atp2a3 |
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3 |
increases methylation |
EXP |
manganese chloride results in increased methylation of ATP2A3 gene |
CTD |
PMID:28801915 |
|
NCBI chr10:59,528,849...59,560,440
Ensembl chr10:59,529,785...59,560,433
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G |
Atp2b2 |
ATPase plasma membrane Ca2+ transporting 2 |
increases methylation decreases expression |
ISO |
manganese chloride results in increased methylation of ATP2B2 gene manganese chloride results in decreased expression of ATP2B2 mRNA |
CTD |
PMID:27913844 |
|
NCBI chr 4:145,704,779...145,948,997
Ensembl chr 4:145,703,046...146,016,325
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G |
Atp2b4 |
ATPase plasma membrane Ca2+ transporting 4 |
increases expression |
EXP |
manganese chloride results in increased expression of ATP2B4 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr13:50,091,644...50,153,808
Ensembl chr13:50,091,430...50,153,823
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G |
Atp5f1c |
ATP synthase F1 subunit gamma |
decreases expression |
EXP |
manganese chloride results in decreased expression of ATP5C1 mRNA |
CTD |
PMID:22281203 |
|
NCBI chr17:72,209,321...72,231,562
Ensembl chr17:72,209,373...72,394,271
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G |
Atp6v1a |
ATPase H+ transporting V1 subunit A |
increases expression |
EXP |
manganese chloride results in increased expression of ATP6V1A mRNA |
CTD |
PMID:28801915 |
|
NCBI chr11:61,531,386...61,584,634
Ensembl chr11:61,531,416...61,584,634
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G |
Atp6v1e2 |
ATPase H+ transporting V1 subunit E2 |
decreases expression |
EXP ISO |
manganese chloride results in decreased expression of ATP6V1E2 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr 6:10,510,370...10,517,059
Ensembl chr 6:10,511,452...10,515,370
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G |
Atp7a |
ATPase copper transporting alpha |
decreases expression affects localization |
EXP |
manganese chloride results in decreased expression of ATP7A mRNA; manganese chloride results in decreased expression of ATP7A protein manganese chloride affects the localization of ATP7A protein |
CTD |
PMID:24614235 |
|
NCBI chr X:77,076,085...77,193,644
Ensembl chr X:77,076,106...77,193,644
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G |
Atp7b |
ATPase copper transporting beta |
affects localization decreases expression |
EXP |
manganese chloride affects the localization of ATP7B protein manganese chloride results in decreased expression of ATP7B mRNA; manganese chloride results in decreased expression of ATP7B protein |
CTD |
PMID:24614235 |
|
NCBI chr16:74,865,516...74,944,935
Ensembl chr16:74,865,516...74,945,286
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G |
Atp8a1 |
ATPase phospholipid transporting 8A1 |
decreases expression |
ISO |
manganese chloride results in decreased expression of ATP8A1 mRNA |
CTD |
PMID:17175027 |
|
NCBI chr14:41,972,398...42,210,555
Ensembl chr14:42,015,347...42,206,311
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G |
Avil |
advillin |
decreases expression increases methylation |
EXP |
manganese chloride results in decreased expression of AVIL mRNA manganese chloride results in increased methylation of AVIL gene |
CTD |
PMID:28801915 |
|
NCBI chr 7:70,292,565...70,310,588
Ensembl chr 7:70,292,565...70,310,588
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G |
Axin2 |
axin 2 |
increases expression |
EXP |
manganese chloride results in increased expression of AXIN2 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr10:97,212,483...97,238,824
Ensembl chr10:97,212,432...97,239,642
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G |
Bach1 |
BTB domain and CNC homolog 1 |
increases expression |
EXP |
manganese chloride results in increased expression of BACH1 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr11:27,364,913...27,398,713
Ensembl chr11:27,364,916...27,398,842 Ensembl chr11:27,364,916...27,398,842
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G |
Bax |
BCL2 associated X, apoptosis regulator |
increases expression multiple interactions |
EXP ISO |
manganese chloride results in increased expression of BAX mRNA; manganese chloride results in increased expression of BAX protein NTF3 protein inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased expression of BAX protein] [manganese chloride results in increased abundance of Manganese] promotes the reaction [Ethanol results in increased expression of BAX protein]; [manganese chloride results in increased abundance of Manganese] which results in increased expression of BAX protein; Ethanol promotes the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased expression of BAX protein]; manganese chloride results in increased expression of and affects the localization of BAX protein [manganese chloride results in increased abundance of Manganese] which results in increased expression of BAX protein; [Plant Extracts co-treated with manganese chloride] affects the expression of BAX protein; benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased expression of BAX protein]; Estradiol inhibits the reaction [manganese chloride results in increased expression of BAX protein]; Tamoxifen inhibits the reaction [manganese chloride results in increased expression of BAX protein] |
CTD |
PMID:17623882 PMID:21704098 PMID:25732873 PMID:26064043 PMID:29183790 PMID:30844427 PMID:30951808 PMID:31676349 PMID:33314588 |
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NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
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G |
Bcl2 |
BCL2, apoptosis regulator |
decreases expression increases expression multiple interactions increases nitrosation |
EXP ISO |
manganese chloride results in decreased expression of BCL2 mRNA; manganese chloride results in decreased expression of BCL2 protein manganese chloride results in increased expression of BCL2 protein manganese chloride results in increased expression of BCL2 mRNA corynoxine B inhibits the reaction [manganese chloride promotes the reaction [BCL2 protein binds to BECN1 protein]]; manganese chloride promotes the reaction [BCL2 protein binds to BECN1 protein]; manganese chloride results in increased expression of and results in decreased phosphorylation of BCL2 protein; N-((3-(aminomethyl)phenyl)methyl)ethanimidamide inhibits the reaction [manganese chloride promotes the reaction [BCL2 protein binds to BECN1 protein]]; N-((3-(aminomethyl)phenyl)methyl)ethanimidamide inhibits the reaction [manganese chloride results in increased expression of and results in decreased phosphorylation of BCL2 protein]; N-((3-(aminomethyl)phenyl)methyl)ethanimidamide inhibits the reaction [manganese chloride results in increased nitrosation of BCL2 protein] [manganese chloride results in increased abundance of Manganese] promotes the reaction [Ethanol results in decreased expression of BCL2 protein]; [manganese chloride results in increased abundance of Manganese] which results in decreased expression of BCL2 protein; Ethanol promotes the reaction [[manganese chloride results in increased abundance of Manganese] which results in decreased expression of BCL2 protein]; manganese chloride results in decreased expression of and affects the localization of BCL2 protein [manganese chloride results in increased abundance of Manganese] which results in decreased expression of BCL2 protein; [Plant Extracts co-treated with manganese chloride] affects the expression of BCL2 protein; Estradiol inhibits the reaction [manganese chloride results in decreased expression of BCL2 protein]; Tamoxifen inhibits the reaction [manganese chloride results in decreased expression of BCL2 protein] |
CTD |
PMID:17623882 PMID:21704098 PMID:25732873 PMID:26064043 PMID:28801915 PMID:28856835 PMID:29183790 PMID:30578841 PMID:30844427 PMID:30951808 PMID:31676349 PMID:33314588 |
|
NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
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G |
Bcl2l1 |
Bcl2-like 1 |
decreases expression |
EXP |
manganese chloride results in decreased expression of BCL2L1 protein |
CTD |
PMID:27107493 |
|
NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
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G |
Bcl2l11 |
BCL2 like 11 |
increases expression decreases expression |
EXP |
manganese chloride results in increased expression of BCL2L11 protein manganese chloride results in decreased expression of BCL2L11 mRNA |
CTD |
PMID:25732873 PMID:28801915 |
|
NCBI chr 3:120,726,906...120,764,192
Ensembl chr 3:120,726,906...120,764,192
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G |
Bcl6b |
BCL6B, transcription repressor |
increases expression |
EXP |
manganese chloride results in increased expression of BCL6B mRNA |
CTD |
PMID:28801915 |
|
NCBI chr10:56,834,363...56,840,058
Ensembl chr10:56,834,364...56,839,437
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G |
Bdkrb2 |
bradykinin receptor B2 |
increases expression |
EXP |
manganese chloride results in increased expression of BDKRB2 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr 6:129,399,468...129,429,676
Ensembl chr 6:129,399,468...129,429,676
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G |
Bdnf |
brain-derived neurotrophic factor |
decreases expression multiple interactions increases methylation increases expression |
ISO EXP |
manganese chloride results in decreased expression of BDNF mRNA [manganese chloride results in increased abundance of Manganese] which results in decreased expression of BDNF protein [manganese chloride results in increased abundance of Manganese] which results in decreased expression of BDNF protein; [manganese chloride results in increased abundance of Manganese] which results in increased expression of BDNF mRNA; CREB1 protein affects the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased expression of BDNF mRNA] manganese chloride results in increased methylation of BDNF gene manganese chloride results in increased expression of BDNF mRNA |
CTD |
PMID:25698507 PMID:28801915 PMID:30951808 PMID:32659473 |
|
NCBI chr 3:100,768,637...100,819,216
Ensembl chr 3:100,768,637...100,819,210
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G |
Becn1 |
beclin 1 |
increases expression affects expression multiple interactions decreases expression |
EXP ISO |
manganese chloride results in increased expression of BECN1 protein manganese chloride affects the expression of BECN1 protein corynoxine B affects the reaction [manganese chloride affects the reaction [HMGB1 protein binds to BECN1 protein]]; corynoxine B inhibits the reaction [manganese chloride promotes the reaction [BCL2 protein binds to BECN1 protein]]; manganese chloride affects the reaction [HMGB1 protein binds to BECN1 protein]; manganese chloride promotes the reaction [BCL2 protein binds to BECN1 protein]; N-((3-(aminomethyl)phenyl)methyl)ethanimidamide inhibits the reaction [manganese chloride promotes the reaction [BCL2 protein binds to BECN1 protein]] manganese chloride results in decreased expression of BECN1 protein wortmannin inhibits the reaction [manganese chloride results in increased expression of BECN1 protein] |
CTD |
PMID:23604964 PMID:28856835 PMID:30578841 PMID:30672645 |
|
NCBI chr10:89,209,944...89,225,297
Ensembl chr10:89,209,940...89,225,297
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G |
Bhlhe40 |
basic helix-loop-helix family, member e40 |
increases expression |
EXP |
manganese chloride results in increased expression of BHLHE40 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr 4:140,703,619...140,709,319
Ensembl chr 4:140,703,619...140,709,319
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G |
Bid |
BH3 interacting domain death agonist |
increases cleavage multiple interactions increases expression |
EXP |
manganese chloride results in increased cleavage of BID protein bafilomycin A1 inhibits the reaction [manganese chloride results in increased expression of BID protein modified form]; bafilomycin A1 inhibits the reaction [manganese chloride results in increased expression of BID protein]; CA 074 methyl ester inhibits the reaction [manganese chloride results in increased expression of BID protein modified form]; CA 074 methyl ester inhibits the reaction [manganese chloride results in increased expression of BID protein]; pepstatin inhibits the reaction [manganese chloride results in increased expression of BID protein modified form]; pepstatin inhibits the reaction [manganese chloride results in increased expression of BID protein] manganese chloride results in increased expression of BID protein; manganese chloride results in increased expression of BID protein modified form |
CTD |
PMID:21704098 PMID:28378122 |
|
NCBI chr 4:153,439,812...153,465,247
Ensembl chr 4:153,442,218...153,465,203
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G |
Birc5 |
baculoviral IAP repeat-containing 5 |
multiple interactions decreases expression |
EXP |
Lithium Chloride inhibits the reaction [manganese chloride results in decreased expression of BIRC5 mRNA] |
CTD |
PMID:24464479 |
|
NCBI chr10:106,856,097...106,864,419
Ensembl chr10:106,856,097...106,864,413
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G |
Birc7 |
baculoviral IAP repeat-containing 7 |
increases expression |
EXP |
manganese chloride results in increased expression of BIRC7 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr 3:176,438,335...176,443,864
Ensembl chr 3:176,439,199...176,443,195
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G |
Bloc1s3 |
biogenesis of lysosomal organelles complex-1, subunit 3 |
increases expression |
EXP |
manganese chloride results in increased expression of BLOC1S3 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr 1:80,414,766...80,417,385
Ensembl chr 1:80,415,686...80,416,273
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G |
Blvra |
biliverdin reductase A |
increases expression |
EXP |
manganese chloride results in increased expression of BLVRA mRNA |
CTD |
PMID:22281203 |
|
NCBI chr 3:119,552,550...119,577,796
Ensembl chr 3:119,561,290...119,577,806
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G |
Bmf |
Bcl2 modifying factor |
decreases expression |
EXP |
manganese chloride results in decreased expression of BMF mRNA |
CTD |
PMID:28801915 |
|
NCBI chr 3:110,303,515...110,324,125
Ensembl chr 3:110,306,067...110,324,084
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G |
Bmp4 |
bone morphogenetic protein 4 |
increases expression |
ISO |
manganese chloride results in increased expression of BMP4 mRNA |
CTD |
PMID:17467022 |
|
NCBI chr15:20,776,060...20,791,013
Ensembl chr15:20,776,054...20,822,740
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G |
Bnip3 |
BCL2 interacting protein 3 |
multiple interactions affects response to substance |
ISO |
[N-(3-(aminomethyl)benzyl)acetamidine results in decreased activity of NOS2 protein] inhibits the reaction [manganese chloride results in increased expression of BNIP3 protein]; Acetylcysteine inhibits the reaction [manganese chloride results in increased expression of BNIP3 protein]; BNIP3 protein affects the reaction [manganese chloride affects the localization of CYCS protein]; Cycloheximide inhibits the reaction [manganese chloride results in increased expression of BNIP3 protein]; Dactinomycin inhibits the reaction [manganese chloride results in increased expression of BNIP3 protein]; Glutathione inhibits the reaction [manganese chloride results in increased expression of BNIP3 protein]; manganese chloride results in increased expression of and affects the localization of BNIP3 protein BNIP3 protein affects the susceptibility to manganese chloride |
CTD |
PMID:19442826 |
|
NCBI chr 1:211,248,098...211,265,282
Ensembl chr 1:211,248,098...211,265,282
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G |
Bpifb6 |
BPI fold containing family B, member 6 |
increases expression |
EXP |
manganese chloride results in increased expression of BPIFB6 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr 3:149,382,312...149,396,130
Ensembl chr 3:149,391,929...149,396,130
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G |
Bsn |
bassoon (presynaptic cytomatrix protein) |
increases expression |
EXP |
manganese chloride results in increased expression of BSN mRNA |
CTD |
PMID:28801915 |
|
NCBI chr 8:116,873,721...116,965,396
Ensembl chr 8:116,873,721...116,965,396
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G |
Btnl5 |
butyrophilin-like 5 |
decreases expression |
EXP |
manganese chloride results in decreased expression of BTNL5 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr20:2,723,576...2,733,181
Ensembl chr20:2,723,572...2,734,296 Ensembl chr20:2,723,572...2,734,296
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G |
Btnl7 |
butyrophilin-like 7 |
decreases expression |
EXP |
manganese chloride results in decreased expression of BTNL7 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr20:2,757,008...2,769,215
Ensembl chr20:2,757,004...2,768,426 Ensembl chr20:2,757,004...2,768,426
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G |
Bub1 |
BUB1 mitotic checkpoint serine/threonine kinase |
decreases expression |
ISO |
manganese chloride results in decreased expression of BUB1 mRNA |
CTD |
PMID:17175027 |
|
NCBI chr 3:120,373,604...120,404,910
Ensembl chr 3:120,373,604...120,404,910
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G |
C1qtnf4 |
C1q and TNF related 4 |
increases expression |
EXP |
manganese chloride results in increased expression of C1QTNF4 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr 3:79,713,580...79,718,018
Ensembl chr 3:79,713,567...79,718,025
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G |
C2cd4b |
C2 calcium-dependent domain containing 4B |
increases expression |
EXP |
manganese chloride results in increased expression of C2CD4B mRNA |
CTD |
PMID:28801915 |
|
NCBI chr 8:73,555,414...73,580,848
Ensembl chr 8:73,593,310...73,594,332
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G |
C4bpa |
complement component 4 binding protein, alpha |
decreases expression |
EXP |
manganese chloride results in decreased expression of C4BPA mRNA |
CTD |
PMID:28801915 |
|
NCBI chr13:47,342,090...47,377,580
Ensembl chr13:47,342,079...47,377,703
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G |
C5 |
complement C5 |
decreases expression |
EXP |
manganese chloride results in decreased expression of C5 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr 3:14,049,993...14,113,931 NCBI chr 3:14,206,466...14,229,141
Ensembl chr 3:14,049,995...14,229,080
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G |
Ca5b |
carbonic anhydrase 5B |
decreases expression |
EXP |
manganese chloride results in decreased expression of CAR5B mRNA |
CTD |
PMID:28801915 |
|
NCBI chr X:32,232,106...32,291,124
Ensembl chr X:32,232,142...32,292,072
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G |
Ca8 |
carbonic anhydrase 8 |
increases expression |
EXP |
manganese chloride results in increased expression of CAR8 mRNA |
CTD |
PMID:26745496 |
|
NCBI chr 5:21,249,018...21,345,810
Ensembl chr 5:21,249,020...21,345,810
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G |
Cables1 |
Cdk5 and Abl enzyme substrate 1 |
decreases expression |
EXP |
manganese chloride results in decreased expression of CABLES1 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr18:3,317,724...3,421,721
Ensembl chr18:3,317,724...3,421,721
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G |
Calcoco2 |
calcium binding and coiled-coil domain 2 |
increases expression |
ISO |
manganese chloride results in increased expression of CALCOCO2 mRNA |
CTD |
PMID:17175027 |
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NCBI chr10:83,935,087...83,963,750
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G |
Cald1 |
caldesmon 1 |
increases expression |
EXP |
manganese chloride results in increased expression of CALD1 mRNA |
CTD |
PMID:28801915 |
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NCBI chr 4:62,103,948...62,291,375
Ensembl chr 4:62,220,736...62,291,489
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G |
Caly |
calcyon neuron-specific vesicular protein |
increases expression |
EXP |
manganese chloride results in increased expression of CALY mRNA |
CTD |
PMID:28801915 |
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NCBI chr 1:212,537,851...212,549,040
Ensembl chr 1:212,537,848...212,549,477
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G |
Camkk2 |
calcium/calmodulin-dependent protein kinase kinase 2 |
increases expression |
ISO |
manganese chloride results in increased expression of CAMKK2 mRNA |
CTD |
PMID:15295902 |
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NCBI chr12:39,253,409...39,302,601
Ensembl chr12:39,253,409...39,302,601
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G |
Camkv |
CaM kinase-like vesicle-associated |
decreases expression |
EXP |
manganese chloride results in decreased expression of CAMKV mRNA |
CTD |
PMID:28801915 |
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NCBI chr 8:116,715,755...116,730,061
Ensembl chr 8:116,715,755...116,730,061
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G |
Camp |
cathelicidin antimicrobial peptide |
increases expression |
EXP |
manganese chloride results in increased expression of CAMP mRNA |
CTD |
PMID:28801915 |
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NCBI chr 8:117,930,557...117,932,371
Ensembl chr 8:117,930,546...117,932,518
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G |
Camta2 |
calmodulin binding transcription activator 2 |
increases expression |
EXP |
manganese chloride results in increased expression of CAMTA2 mRNA |
CTD |
PMID:28801915 |
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NCBI chr10:57,291,192...57,309,638
Ensembl chr10:57,291,192...57,309,298
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G |
Capn5 |
calpain 5 |
increases expression |
EXP |
manganese chloride results in increased expression of CAPN5 mRNA |
CTD |
PMID:28801915 |
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NCBI chr 1:163,073,134...163,129,736
Ensembl chr 1:163,073,124...163,129,641
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G |
Card14 |
caspase recruitment domain family, member 14 |
increases methylation |
ISO |
manganese chloride results in increased methylation of CARD14 gene |
CTD |
PMID:27913844 |
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NCBI chr10:108,440,480...108,469,012
Ensembl chr10:108,440,950...108,468,310
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G |
Card9 |
caspase recruitment domain family, member 9 |
decreases expression |
EXP |
manganese chloride results in decreased expression of CARD9 mRNA |
CTD |
PMID:28801915 |
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NCBI chr 3:3,798,346...3,806,841
Ensembl chr 3:3,798,347...3,806,713
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G |
Casp12 |
caspase 12 |
multiple interactions increases cleavage increases expression |
ISO EXP |
Deferoxamine promotes the reaction [manganese chloride results in increased cleavage of and results in increased activity of CASP12 protein]; manganese chloride results in increased cleavage of and results in increased activity of CASP12 protein Plant Extracts inhibits the reaction [manganese chloride results in increased cleavage of CASP12 protein] SNCA protein promotes the reaction [manganese chloride results in increased expression of CASP12 protein] manganese chloride results in increased expression of CASP12 mRNA; manganese chloride results in increased expression of CASP12 protein |
CTD |
PMID:23764342 PMID:23934647 PMID:23948121 PMID:25732873 PMID:26064043 PMID:28801915 |
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NCBI chr 8:2,658,892...2,686,160
Ensembl chr 8:2,659,865...2,686,160
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G |
Casp2 |
caspase 2 |
increases expression |
EXP |
manganese chloride results in increased expression of CASP2 mRNA |
CTD |
PMID:28801915 |
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NCBI chr 4:71,652,358...71,670,228
Ensembl chr 4:71,652,354...71,670,239
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G |
Casp3 |
caspase 3 |
increases cleavage increases methylation increases expression increases activity multiple interactions |
ISO EXP |
manganese chloride results in increased cleavage of CASP3 protein manganese chloride results in increased methylation of CASP3 gene manganese chloride results in increased expression of CASP3 protein manganese chloride results in increased activity of CASP3 protein Deferoxamine promotes the reaction [manganese chloride results in increased activity of CASP3 protein]; SNCA protein inhibits the reaction [manganese chloride results in increased activity of CASP3 protein] [manganese chloride results in increased abundance of Manganese] which results in increased cleavage of CASP3 protein; Plant Extracts inhibits the reaction [manganese chloride results in increased cleavage of CASP3 protein]; PRNP protein inhibits the reaction [manganese chloride results in increased activity of CASP3 protein] manganese chloride results in increased expression of CASP3 mRNA; manganese chloride results in increased expression of CASP3 protein; manganese chloride results in increased expression of CASP3 protein modified form [manganese chloride results in increased abundance of Manganese] promotes the reaction [Ethanol results in increased expression of CASP3 protein]; [manganese chloride results in increased abundance of Manganese] which results in increased cleavage of CASP3 protein; [manganese chloride results in increased abundance of Manganese] which results in increased expression of CASP3 protein; Acetylcysteine inhibits the reaction [manganese chloride results in increased expression of CASP3 protein modified form]; bafilomycin A1 inhibits the reaction [manganese chloride results in increased cleavage of CASP3 protein]; CA 074 methyl ester inhibits the reaction [manganese chloride results in increased cleavage of CASP3 protein]; Ethanol promotes the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased expression of CASP3 protein]; GW 506033X inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased cleavage of CASP3 protein]; Lithium Chloride inhibits the reaction [manganese chloride results in increased activity of CASP3 protein]; pepstatin inhibits the reaction [manganese chloride results in increased cleavage of CASP3 protein]; pyrazolanthrone inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased cleavage of CASP3 protein]; pyrazolanthrone inhibits the reaction [manganese chloride results in increased cleavage of CASP3 protein]; pyrazolanthrone inhibits the reaction [manganese chloride results in increased expression of CASP3 protein]; Quercetin inhibits the reaction [manganese chloride results in increased activity of CASP3 protein]; rhodioloside inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased cleavage of CASP3 protein]; U 0126 inhibits the reaction [manganese chloride results in increased expression of CASP3 mRNA]; U 0126 inhibits the reaction [manganese chloride results in increased expression of CASP3 protein] |
CTD |
PMID:16787641 PMID:17483122 PMID:18178165 PMID:19815061 PMID:23764342 PMID:24464479 PMID:25416158 PMID:25732873 PMID:26064043 PMID:27913844 PMID:28040552 PMID:28378122 PMID:28778520 PMID:30844427 PMID:30991096 PMID:31676349 PMID:32574669 PMID:33314588 |
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NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
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G |
Casp4 |
caspase 4 |
increases expression |
EXP |
manganese chloride results in increased expression of CASP4 mRNA |
CTD |
PMID:28801915 |
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NCBI chr 8:2,616,391...2,651,682
Ensembl chr 8:2,635,851...2,651,652
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G |
Casp8 |
caspase 8 |
increases cleavage multiple interactions |
EXP |
manganese chloride results in increased cleavage of CASP8 protein bafilomycin A1 inhibits the reaction [manganese chloride results in increased cleavage of CASP8 protein]; CA 074 methyl ester inhibits the reaction [manganese chloride results in increased cleavage of CASP8 protein]; pepstatin inhibits the reaction [manganese chloride results in increased cleavage of CASP8 protein] |
CTD |
PMID:21704098 PMID:28378122 |
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NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
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G |
Casp9 |
caspase 9 |
increases activity multiple interactions increases cleavage |
ISO EXP |
manganese chloride results in increased activity of CASP9 protein bafilomycin A1 inhibits the reaction [manganese chloride results in increased cleavage of CASP9 protein]; CA 074 methyl ester inhibits the reaction [manganese chloride results in increased cleavage of CASP9 protein]; pepstatin inhibits the reaction [manganese chloride results in increased cleavage of CASP9 protein] SNCA protein inhibits the reaction [manganese chloride results in increased activity of CASP9 protein] PRNP protein inhibits the reaction [manganese chloride results in increased activity of CASP9 protein] |
CTD |
PMID:16787641 PMID:17483122 PMID:21704098 PMID:25416158 PMID:28378122 |
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NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
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G |
Cat |
catalase |
decreases activity decreases expression multiple interactions |
EXP ISO |
manganese chloride results in decreased activity of CAT protein manganese chloride results in decreased expression of CAT protein [manganese chloride results in increased abundance of Manganese] promotes the reaction [Ethanol results in decreased activity of CAT protein]; [manganese chloride results in increased abundance of Manganese] which results in decreased activity of CAT protein; Ethanol promotes the reaction [[manganese chloride results in increased abundance of Manganese] which results in decreased activity of CAT protein]; Quercetin inhibits the reaction [manganese chloride results in decreased activity of CAT protein]; Silymarin inhibits the reaction [manganese chloride results in decreased activity of CAT protein] [manganese chloride results in increased abundance of Manganese] which results in decreased activity of CAT protein; [Plant Extracts co-treated with manganese chloride] results in increased expression of CAT protein; Estradiol inhibits the reaction [manganese chloride results in decreased expression of CAT protein]; Tamoxifen inhibits the reaction [manganese chloride results in decreased expression of CAT protein] |
CTD |
PMID:20503066 PMID:22033861 PMID:22192907 PMID:26064043 PMID:28040552 PMID:29183790 PMID:30844427 PMID:32445656 PMID:33314588 |
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NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
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G |
Catip |
ciliogenesis associated TTC17 interacting protein |
increases expression |
EXP |
manganese chloride results in increased expression of CATIP mRNA |
CTD |
PMID:28801915 |
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NCBI chr 9:81,644,239...81,652,045
Ensembl chr 9:81,644,355...81,651,989
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G |
Catsperd |
cation channel sperm associated auxiliary subunit delta |
increases expression |
EXP |
manganese chloride results in increased expression of CATSPERD mRNA |
CTD |
PMID:28801915 |
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NCBI chr 9:10,390,307...10,428,666
Ensembl chr 9:10,390,308...10,427,746
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G |
Cav2 |
caveolin 2 |
decreases expression |
EXP |
manganese chloride results in decreased expression of CAV2 mRNA |
CTD |
PMID:28801915 |
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NCBI chr 4:44,573,264...44,580,640
Ensembl chr 4:44,573,264...44,580,638
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G |
Cbarp |
CACN subunit beta associated regulatory protein |
increases expression |
EXP |
manganese chloride results in increased expression of DOS mRNA |
CTD |
PMID:28801915 |
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NCBI chr 7:12,433,422...12,441,048
Ensembl chr 7:12,433,933...12,441,048
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G |
Cbs |
cystathionine beta synthase |
decreases expression |
EXP |
manganese chloride results in decreased expression of CBS mRNA |
CTD |
PMID:28801915 |
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NCBI chr20:10,361,987...10,386,663
Ensembl chr20:10,361,988...10,386,751
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G |
Ccdc15 |
coiled-coil domain containing 15 |
increases expression |
EXP |
manganese chloride results in increased expression of CCDC15 mRNA |
CTD |
PMID:28801915 |
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NCBI chr 8:39,759,077...39,830,235
Ensembl chr 8:39,762,035...39,830,306
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G |
Ccdc175 |
coiled-coil domain containing 175 |
increases expression |
EXP |
manganese chloride results in increased expression of CCDC175 mRNA |
CTD |
PMID:28801915 |
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NCBI chr 6:94,849,910...94,933,175
Ensembl chr 6:94,849,989...94,932,806
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G |
Ccdc96 |
coiled-coil domain containing 96 |
increases expression |
EXP |
manganese chloride results in increased expression of CCDC96 mRNA |
CTD |
PMID:28801915 |
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NCBI chr14:79,443,151...79,445,591
Ensembl chr14:79,443,543...79,445,471
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G |
Ccl17 |
C-C motif chemokine ligand 17 |
increases expression |
EXP |
manganese chloride results in increased expression of CCL17 mRNA |
CTD |
PMID:28801915 |
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NCBI chr19:10,619,220...10,620,671
Ensembl chr19:10,619,220...10,620,671
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G |
Ccl19 |
C-C motif chemokine ligand 19 |
increases expression |
EXP |
manganese chloride results in increased expression of CCL19 mRNA |
CTD |
PMID:28801915 |
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NCBI chr 5:58,181,025...58,182,969
Ensembl chr 5:58,181,026...58,183,017
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G |
Ccl2 |
C-C motif chemokine ligand 2 |
multiple interactions decreases secretion |
ISO EXP |
manganese chloride inhibits the reaction [CCL2 protein results in increased expression of ICAM1 protein]; manganese chloride inhibits the reaction [Glucose results in increased secretion of CCL2 protein] manganese chloride results in decreased secretion of CCL2 protein |
CTD |
PMID:23329836 |
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NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
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G |
Ccl5 |
C-C motif chemokine ligand 5 |
increases expression |
EXP |
manganese chloride results in increased expression of CCL5 mRNA |
CTD |
PMID:28801915 |
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NCBI chr10:70,739,764...70,744,303
Ensembl chr10:70,739,800...70,744,315
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G |
Ccl7 |
C-C motif chemokine ligand 7 |
increases expression |
ISO EXP |
manganese chloride results in increased expression of CCL7 mRNA |
CTD |
PMID:17175027 PMID:28801915 |
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NCBI chr10:69,423,083...69,424,933
Ensembl chr10:69,423,086...69,424,979
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G |
Ccn2 |
cellular communication network factor 2 |
increases expression increases methylation |
ISO EXP |
manganese chloride results in increased expression of CCN2 mRNA manganese chloride results in increased methylation of CCN2 gene |
CTD |
PMID:17467022 PMID:28801915 |
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NCBI chr 1:21,851,657...21,854,773
Ensembl chr 1:21,851,660...21,854,773
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G |
Ccna1 |
cyclin A1 |
increases expression |
EXP |
manganese chloride results in increased expression of CCNA1 mRNA |
CTD |
PMID:26745496 |
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NCBI chr 2:144,456,689...144,503,570
Ensembl chr 2:144,458,153...144,467,912
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G |
Ccnb2 |
cyclin B2 |
decreases expression |
ISO |
manganese chloride results in decreased expression of CCNB2 mRNA |
CTD |
PMID:17175027 |
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NCBI chr 8:76,847,972...76,861,165
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G |
Ccng1 |
cyclin G1 |
increases expression |
EXP |
manganese chloride results in increased expression of CCNG1 mRNA |
CTD |
PMID:28801915 |
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NCBI chr10:25,903,925...25,910,298
Ensembl chr10:25,903,911...25,910,325
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G |
Cd28 |
Cd28 molecule |
multiple interactions |
ISO |
[manganese chloride co-treated with LCK protein] results in increased phosphorylation of CD28 protein; manganese chloride promotes the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of CD28 protein]; Tetradecanoylphorbol Acetate inhibits the reaction [[manganese chloride co-treated with LCK protein] results in increased phosphorylation of CD28 protein] |
CTD |
PMID:8662792 |
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NCBI chr 9:67,546,408...67,573,858
Ensembl chr 9:67,546,408...67,571,871
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G |
Cd44 |
CD44 molecule (Indian blood group) |
increases expression |
EXP |
manganese chloride results in increased expression of CD44 mRNA |
CTD |
PMID:28801915 |
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NCBI chr 3:92,695,083...92,783,820
Ensembl chr 3:92,696,313...92,783,658
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G |
Cd48 |
Cd48 molecule |
increases expression |
ISO |
manganese chloride results in increased expression of CD48 mRNA |
CTD |
PMID:17175027 |
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NCBI chr13:90,116,601...90,140,371
Ensembl chr13:90,116,843...90,140,371
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G |
Cd6 |
Cd6 molecule |
decreases expression |
EXP |
manganese chloride results in decreased expression of CD6 mRNA |
CTD |
PMID:28801915 |
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NCBI chr 1:226,848,399...226,887,259
Ensembl chr 1:226,848,403...226,887,156
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G |
Cd74 |
CD74 molecule |
increases expression |
EXP |
manganese chloride results in increased expression of CD74 mRNA |
CTD |
PMID:28801915 |
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NCBI chr18:56,071,420...56,080,851
Ensembl chr18:56,071,478...56,080,849
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G |
Cd86 |
CD86 molecule |
increases expression |
ISO |
manganese chloride results in increased expression of CD86 protein |
CTD |
PMID:15737199 |
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NCBI chr11:67,060,305...67,117,990
Ensembl chr11:67,082,193...67,118,795
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G |
Cd8b |
CD8b molecule |
increases expression |
ISO |
manganese chloride results in increased expression of CD8B mRNA; manganese chloride results in increased expression of CD8B1 mRNA |
CTD |
PMID:17175027 |
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NCBI chr 4:99,185,960...99,201,887
Ensembl chr 4:99,185,885...99,202,023
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G |
Cdc42ep3 |
CDC42 effector protein 3 |
increases expression |
EXP |
manganese chloride results in increased expression of CDC42EP3 mRNA |
CTD |
PMID:28801915 |
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NCBI chr 6:1,922,500...1,942,972
Ensembl chr 6:1,922,500...1,942,972
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G |
Cdhr4 |
cadherin-related family member 4 |
decreases expression |
EXP |
manganese chloride results in decreased expression of CDHR4 mRNA |
CTD |
PMID:28801915 |
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NCBI chr 8:116,771,377...116,779,242
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G |
Cdkn1a |
cyclin-dependent kinase inhibitor 1A |
multiple interactions affects localization increases expression |
EXP |
Cycloheximide inhibits the reaction [manganese chloride results in increased expression of CDKN1A protein] manganese chloride affects the localization of CDKN1A protein manganese chloride results in increased expression of CDKN1A mRNA; manganese chloride results in increased expression of CDKN1A protein |
CTD |
PMID:22542671 PMID:28801915 |
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NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
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G |
Cdkn1c |
cyclin-dependent kinase inhibitor 1C |
decreases expression |
EXP |
manganese chloride results in decreased expression of CDKN1C mRNA |
CTD |
PMID:28801915 |
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NCBI chr 1:216,661,067...216,663,791
Ensembl chr 1:216,661,080...216,663,721
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G |
Cdkn2b |
cyclin-dependent kinase inhibitor 2B |
increases expression |
EXP |
manganese chloride results in increased expression of CDKN2B mRNA |
CTD |
PMID:28801915 |
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NCBI chr 5:107,834,353...107,857,428
Ensembl chr 5:107,845,951...107,858,104
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G |
Cdkn2c |
cyclin-dependent kinase inhibitor 2C |
decreases expression |
ISO |
manganese chloride results in decreased expression of CDKN2C mRNA |
CTD |
PMID:17175027 |
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NCBI chr 5:129,347,731...129,352,886
Ensembl chr 5:129,347,732...129,352,886
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G |
Cdkn3 |
cyclin-dependent kinase inhibitor 3 |
decreases expression |
ISO |
manganese chloride results in decreased expression of CDKN3 mRNA |
CTD |
PMID:17175027 |
|
NCBI chr15:23,553,171...23,564,538
Ensembl chr15:23,553,128...23,564,535
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G |
Cdnf |
cerebral dopamine neurotrophic factor |
increases expression |
EXP |
manganese chloride results in increased expression of CDNF mRNA |
CTD |
PMID:28801915 |
|
NCBI chr17:78,721,230...78,735,324
Ensembl chr17:78,719,111...78,735,324
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G |
Cdyl2 |
chromodomain Y-like 2 |
increases expression |
EXP |
manganese chloride results in increased expression of CDYL2 mRNA |
CTD |
PMID:28801915 |
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NCBI chr19:49,087,131...49,222,528
Ensembl chr19:49,093,355...49,198,073
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G |
Cebpd |
CCAAT/enhancer binding protein delta |
increases expression |
ISO |
manganese chloride results in increased expression of CEBPD mRNA |
CTD |
PMID:17175027 |
|
NCBI chr11:89,008,008...89,009,146
Ensembl chr11:89,008,008...89,009,146
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G |
Celsr1 |
cadherin, EGF LAG seven-pass G-type receptor 1 |
increases expression |
ISO |
manganese chloride results in increased expression of CELSR1 mRNA |
CTD |
PMID:17175027 |
|
NCBI chr 7:126,774,010...126,914,085
Ensembl chr 7:126,775,516...126,913,585
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G |
Cep112 |
centrosomal protein 112 |
increases expression |
EXP |
manganese chloride results in increased expression of CEP112 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr10:96,660,294...97,146,426
Ensembl chr10:96,663,740...97,146,424
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G |
Cep128 |
centrosomal protein 128 |
decreases expression |
ISO |
manganese chloride results in decreased expression of CEP128 mRNA |
CTD |
PMID:17175027 |
|
NCBI chr 6:114,759,474...115,158,004
Ensembl chr 6:114,759,474...115,157,854
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G |
Cers1 |
ceramide synthase 1 |
increases expression |
EXP |
manganese chloride results in increased expression of CERS1 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr16:20,845,580...20,860,789
Ensembl chr16:20,845,576...20,860,789
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G |
Cers6 |
ceramide synthase 6 |
increases expression |
EXP |
manganese chloride results in increased expression of CERS6 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr 3:55,094,240...55,338,370
Ensembl chr 3:55,094,637...55,338,445
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G |
Cflar |
CASP8 and FADD-like apoptosis regulator |
increases expression |
EXP |
manganese chloride results in increased expression of CFLAR mRNA |
CTD |
PMID:28801915 |
|
NCBI chr 9:65,534,608...65,586,395
Ensembl chr 9:65,534,704...65,587,251
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G |
Cftr |
CF transmembrane conductance regulator |
increases expression |
EXP |
manganese chloride results in increased expression of CFTR mRNA |
CTD |
PMID:28801915 |
|
NCBI chr 4:42,693,263...42,860,679
Ensembl chr 4:42,692,836...42,860,676
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G |
Cgref1 |
cell growth regulator with EF hand domain 1 |
increases expression |
EXP |
manganese chloride results in increased expression of CGREF1 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr 6:26,797,126...26,809,132
Ensembl chr 6:26,797,126...26,809,129
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G |
Ch25h |
cholesterol 25-hydroxylase |
increases expression |
EXP |
manganese chloride results in increased expression of CH25H mRNA |
CTD |
PMID:28801915 |
|
NCBI chr 1:252,807,062...252,811,409
Ensembl chr 1:252,807,065...252,808,380
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G |
Chat |
choline O-acetyltransferase |
multiple interactions |
ISO |
[manganese chloride results in increased abundance of Manganese] which results in decreased activity of CHAT protein |
CTD |
PMID:30738988 |
|
NCBI chr16:8,576,858...8,686,131
Ensembl chr16:8,577,840...8,686,131
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G |
Chml |
CHM like Rab escort protein |
increases expression |
EXP |
manganese chloride results in increased expression of CHML mRNA |
CTD |
PMID:28801915 |
|
NCBI chr13:93,740,759...93,742,624
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G |
Chrna7 |
cholinergic receptor nicotinic alpha 7 subunit |
decreases expression |
ISO |
manganese chloride results in decreased expression of CHRNA7 protein |
CTD |
PMID:25874029 |
|
NCBI chr 1:123,897,341...124,039,263
Ensembl chr 1:123,899,657...124,039,196
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G |
Chst10 |
carbohydrate sulfotransferase 10 |
increases expression |
EXP |
manganese chloride results in increased expression of CHST10 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr 9:45,528,928...45,559,365
Ensembl chr 9:45,528,928...45,559,140
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G |
Chuk |
component of inhibitor of nuclear factor kappa B kinase complex |
multiple interactions increases phosphorylation |
EXP |
15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [manganese chloride results in increased phosphorylation of CHUK protein] |
CTD |
PMID:22245093 |
|
NCBI chr 1:263,848,829...263,884,354
Ensembl chr 1:263,848,884...263,885,169
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G |
Ciita |
class II, major histocompatibility complex, transactivator |
increases expression |
EXP |
manganese chloride results in increased expression of CIITA mRNA |
CTD |
PMID:28801915 |
|
NCBI chr10:5,212,621...5,260,641
Ensembl chr10:5,213,350...5,260,608
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G |
Cish |
cytokine inducible SH2-containing protein |
increases expression |
EXP |
manganese chloride results in increased expression of CISH mRNA |
CTD |
PMID:28801915 |
|
NCBI chr 8:116,054,547...116,059,494
Ensembl chr 8:116,054,465...116,060,723
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G |
Cited1 |
Cbp/p300-interacting transactivator with Glu/Asp-rich carboxy-terminal domain 1 |
decreases expression |
EXP |
manganese chloride results in decreased expression of CITED1 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr X:72,128,996...72,133,692
Ensembl chr X:72,128,994...72,133,692
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G |
Cks2 |
CDC28 protein kinase regulatory subunit 2 |
decreases expression |
ISO |
manganese chloride results in decreased expression of CKS2 mRNA |
CTD |
PMID:17175027 |
|
NCBI chr17:13,587,664...13,593,423
Ensembl chr17:13,587,665...13,593,423
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G |
Cldn23 |
claudin 23 |
increases expression |
EXP |
manganese chloride results in increased expression of CLDN23 mRNA |
CTD |
PMID:26745496 |
|
NCBI chr16:59,988,603...59,990,327
Ensembl chr16:59,988,603...59,990,326
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G |
Cldn4 |
claudin 4 |
increases expression |
EXP |
manganese chloride results in increased expression of CLDN4 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr12:24,761,210...24,763,008
Ensembl chr12:24,761,210...24,763,005
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G |
Cldn9 |
claudin 9 |
decreases expression |
EXP |
manganese chloride results in decreased expression of CLDN9 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr10:13,003,010...13,004,441
Ensembl chr10:13,003,011...13,004,441
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G |
Clec4f |
C-type lectin domain family 4, member F |
increases methylation |
EXP |
manganese chloride results in increased methylation of CLEC4F gene |
CTD |
PMID:28801915 |
|
NCBI chr 4:115,322,300...115,332,021
Ensembl chr 4:115,322,291...115,332,052
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G |
Clock |
clock circadian regulator |
decreases expression |
EXP |
manganese chloride results in decreased expression of CLOCK mRNA |
CTD |
PMID:28511934 |
|
NCBI chr14:34,418,226...34,502,218
Ensembl chr14:34,446,616...34,502,218
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G |
Cmpk2 |
cytidine/uridine monophosphate kinase 2 |
increases expression increases methylation |
EXP |
manganese chloride results in increased expression of CMPK2 mRNA manganese chloride results in increased methylation of CMPK2 gene |
CTD |
PMID:28801915 |
|
NCBI chr 6:45,683,242...45,694,824
Ensembl chr 6:45,683,234...45,694,822
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G |
Cnksr1 |
connector enhancer of kinase suppressor of Ras 1 |
increases expression |
EXP |
manganese chloride results in increased expression of CNKSR1 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr 5:152,447,348...152,458,005
Ensembl chr 5:152,446,845...152,458,023
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G |
Cnot2 |
CCR4-NOT transcription complex, subunit 2 |
decreases expression |
ISO |
manganese chloride results in decreased expression of CNOT2 mRNA |
CTD |
PMID:17175027 |
|
NCBI chr 7:59,526,105...59,617,307
Ensembl chr 7:59,527,124...59,587,385
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G |
Cnot6l |
CCR4-NOT transcription complex, subunit 6-like |
increases expression |
ISO |
manganese chloride results in increased expression of CNOT6L mRNA |
CTD |
PMID:17175027 |
|
NCBI chr14:15,059,101...15,148,255
Ensembl chr14:15,059,387...15,146,586
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G |
Cntn4 |
contactin 4 |
decreases expression |
ISO |
manganese chloride results in decreased expression of CNTN4 mRNA |
CTD |
PMID:15295902 |
|
NCBI chr 4:137,785,166...138,787,527
Ensembl chr 4:138,269,142...138,787,525
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G |
Col12a1 |
collagen type XII alpha 1 chain |
decreases expression |
ISO |
manganese chloride results in decreased expression of COL12A1 mRNA |
CTD |
PMID:17175027 |
|
NCBI chr 8:87,042,820...87,150,701
Ensembl chr 8:87,040,799...87,158,368
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G |
Col15a1 |
collagen type XV alpha 1 chain |
increases expression |
EXP |
manganese chloride results in increased expression of COL15A1 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr 5:62,840,360...62,950,240
Ensembl chr 5:64,476,317...64,542,645 Ensembl chr 5:64,476,317...64,542,645
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G |
Col17a1 |
collagen type XVII alpha 1 chain |
increases expression |
EXP |
manganese chloride results in increased expression of COL17A1 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr 1:267,416,681...267,465,049
Ensembl chr 1:267,417,459...267,463,705
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G |
Col18a1 |
collagen type XVIII alpha 1 chain |
increases expression |
ISO |
manganese chloride results in increased expression of COL18A1 mRNA |
CTD |
PMID:17467022 |
|
NCBI chr20:12,225,202...12,332,858
Ensembl chr20:12,225,202...12,332,858
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G |
Col4a5 |
collagen type IV alpha 5 chain |
decreases expression |
EXP |
manganese chloride results in decreased expression of COL4A5 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr X:112,769,595...112,983,720
Ensembl chr X:112,769,645...112,983,685
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G |
Col5a2 |
collagen type V alpha 2 chain |
increases expression |
EXP |
manganese chloride results in increased expression of COL5A2 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr 9:52,091,088...52,238,735
Ensembl chr 9:52,092,511...52,238,564
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G |
Col6a1 |
collagen type VI alpha 1 chain |
increases expression |
EXP |
manganese chloride results in increased expression of COL6A1 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr20:12,657,913...12,676,370
Ensembl chr20:12,658,065...12,675,561
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G |
Col7a1 |
collagen type VII alpha 1 chain |
increases expression |
EXP |
manganese chloride results in increased expression of COL7A1 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr 8:117,694,441...117,726,844
Ensembl chr 8:117,694,605...117,726,844
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G |
Col8a1 |
collagen type VIII alpha 1 chain |
increases expression |
EXP |
manganese chloride results in increased expression of COL8A1 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr11:44,877,690...45,006,203
Ensembl chr11:44,877,859...45,007,891
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G |
Colec10 |
collectin subfamily member 10 |
decreases expression |
EXP |
manganese chloride results in decreased expression of COLEC10 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr 7:93,975,451...94,035,999
Ensembl chr 7:93,975,451...94,035,999
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G |
Colec12 |
collectin sub-family member 12 |
decreases expression |
EXP |
manganese chloride results in decreased expression of COLEC12 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr18:867,048...1,054,047
Ensembl chr18:867,048...1,052,606
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G |
Copg2 |
COPI coat complex subunit gamma 2 |
increases expression |
EXP |
manganese chloride results in increased expression of COPG2 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr 4:58,064,394...58,195,242
Ensembl chr 4:58,064,833...58,195,143
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G |
Cox6a2 |
cytochrome c oxidase subunit 6A2 |
increases expression |
EXP |
manganese chloride results in increased expression of COX6A2 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr 1:199,624,037...199,626,255
Ensembl chr 1:199,624,037...199,624,783
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G |
Cplx2 |
complexin 2 |
increases expression |
EXP |
manganese chloride results in increased expression of CPLX2 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr17:10,756,871...10,828,811
Ensembl chr17:10,756,285...10,818,835
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G |
Cpm |
carboxypeptidase M |
decreases expression |
ISO |
manganese chloride results in decreased expression of CPM mRNA |
CTD |
PMID:17175027 |
|
NCBI chr 7:60,654,350...60,714,620
Ensembl chr 7:60,654,350...60,714,620
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G |
Cracdl |
CRACD like |
increases expression |
EXP |
manganese chloride results in increased expression of CRACDL mRNA |
CTD |
PMID:28801915 |
|
NCBI chr 9:44,194,348...44,309,816
Ensembl chr 9:44,194,325...44,237,117
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G |
Creb1 |
cAMP responsive element binding protein 1 |
increases phosphorylation multiple interactions |
EXP ISO |
manganese chloride results in increased phosphorylation of CREB1 protein [manganese chloride results in increased abundance of Manganese] which results in decreased expression of CREB1 protein; NTF3 protein inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in decreased phosphorylation of CREB1 protein] [manganese chloride results in increased abundance of Manganese] which results in decreased phosphorylation of CREB1 protein; [manganese chloride results in increased abundance of Manganese] which results in increased phosphorylation of CREB1 protein; benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in decreased phosphorylation of CREB1 protein] 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased phosphorylation of CREB1 protein]; [manganese chloride results in increased abundance of Manganese] which results in increased phosphorylation of CREB1 protein; CREB1 protein affects the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased expression of BDNF mRNA]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased phosphorylation of CREB1 protein]; SB 203580 inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased phosphorylation of CREB1 protein]; SB 203580 inhibits the reaction [manganese chloride results in increased phosphorylation of CREB1 protein] |
CTD |
PMID:16787641 PMID:30951808 PMID:31676349 PMID:32659473 |
|
NCBI chr 9:71,229,753...71,298,994
Ensembl chr 9:71,230,108...71,293,435
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G |
Crebl2 |
cAMP responsive element binding protein-like 2 |
increases expression |
EXP |
manganese chloride results in increased expression of CREBL2 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr 4:168,599,387...168,625,239
Ensembl chr 4:168,599,331...168,619,764
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G |
Crk |
CRK proto-oncogene, adaptor protein |
increases expression |
EXP |
manganese chloride results in increased expression of CRK mRNA |
CTD |
PMID:28801915 |
|
NCBI chr10:63,829,731...63,855,999
Ensembl chr10:63,829,807...63,852,780
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G |
Cry1 |
cryptochrome circadian regulator 1 |
decreases expression |
EXP |
manganese chloride results in decreased expression of CRY1 mRNA |
CTD |
PMID:28511934 |
|
NCBI chr 7:24,534,593...24,634,098
Ensembl chr 7:24,534,615...24,634,097
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G |
Cryaa |
crystallin, alpha A |
increases methylation |
EXP |
manganese chloride results in increased methylation of CRYAA gene |
CTD |
PMID:28801915 |
|
NCBI chr20:10,438,444...10,442,189
Ensembl chr20:10,438,444...10,442,187
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G |
Cryab |
crystallin, alpha B |
decreases expression |
EXP |
manganese chloride results in decreased expression of CRYAB mRNA |
CTD |
PMID:28801915 |
|
NCBI chr 8:55,178,543...55,182,546
Ensembl chr 8:55,178,289...55,182,545
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G |
Cryba4 |
crystallin, beta A4 |
increases expression |
EXP |
manganese chloride results in increased expression of CRYBA4 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr12:50,407,843...50,414,434
Ensembl chr12:50,407,843...50,414,432
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G |
Csf2 |
colony stimulating factor 2 |
multiple interactions increases expression |
ISO EXP |
manganese chloride promotes the reaction [SNCA protein results in increased expression of CSF2 mRNA] manganese chloride results in increased expression of CSF2 mRNA |
CTD |
PMID:28539244 PMID:28801915 |
|
NCBI chr10:39,602,089...39,604,070
Ensembl chr10:39,602,089...39,604,070
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G |
Csf3 |
colony stimulating factor 3 |
increases expression |
EXP |
manganese chloride results in increased expression of CSF3 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr10:86,616,785...86,619,160
Ensembl chr10:86,616,785...86,619,157
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G |
Cspg4 |
chondroitin sulfate proteoglycan 4 |
increases expression increases methylation |
EXP |
manganese chloride results in increased expression of CSPG4 mRNA manganese chloride results in increased methylation of CSPG4 gene |
CTD |
PMID:28801915 |
|
NCBI chr 8:61,532,465...61,567,510
Ensembl chr 8:61,532,465...61,567,510
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G |
Csrp3 |
cysteine and glycine rich protein 3 |
increases expression |
EXP |
manganese chloride results in increased expression of CSRP3 mRNA |
CTD |
PMID:26745496 |
|
NCBI chr 1:104,147,205...104,166,389
Ensembl chr 1:104,147,206...104,166,367
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G |
Cstf2 |
cleavage stimulation factor subunit 2 |
increases expression |
EXP |
manganese chloride results in increased expression of CSTF2 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr X:104,882,726...104,909,746
Ensembl chr X:104,882,704...104,909,739
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G |
Ctnna1 |
catenin alpha 1 |
decreases expression |
ISO |
manganese chloride results in decreased expression of CTNNA1 mRNA |
CTD |
PMID:17175027 |
|
NCBI chr18:27,923,229...28,055,972
Ensembl chr18:27,923,572...28,055,960
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G |
Ctnnb1 |
catenin beta 1 |
decreases expression multiple interactions |
ISO EXP |
manganese chloride results in decreased expression of CTNNB1 mRNA manganese chloride results in decreased expression of CTNNB1 protein Lithium Chloride inhibits the reaction [manganese chloride results in decreased expression of CTNNB1 protein] |
CTD |
PMID:17175027 PMID:24464479 |
|
NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372
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G |
Ctnnd1 |
catenin delta 1 |
increases expression |
EXP |
manganese chloride results in increased expression of CTNND1 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr 3:72,001,904...72,053,047
Ensembl chr 3:72,002,152...72,053,049
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G |
Ctsd |
cathepsin D |
increases expression affects localization |
EXP |
manganese chloride results in increased expression of CTSD protein manganese chloride affects the localization of CTSD protein |
CTD |
PMID:28378122 |
|
NCBI chr 1:215,541,570...215,553,446
Ensembl chr 1:215,541,542...215,553,451
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G |
Ctsw |
cathepsin W |
increases expression |
EXP |
manganese chloride results in increased expression of CTSW mRNA |
CTD |
PMID:28801915 |
|
NCBI chr 1:220,844,579...220,847,967
Ensembl chr 1:220,844,558...220,848,153
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G |
Cx3cl1 |
C-X3-C motif chemokine ligand 1 |
increases expression |
EXP |
manganese chloride results in increased expression of CX3CL1 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr19:10,644,267...10,654,861
Ensembl chr19:10,644,244...10,653,800
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G |
Cxcl1 |
C-X-C motif chemokine ligand 1 |
increases methylation increases expression |
EXP |
manganese chloride results in increased methylation of CXCL1 gene manganese chloride results in increased expression of CXCL1 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr14:18,743,678...18,745,457
Ensembl chr14:18,743,685...18,745,457
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G |
Cxcl10 |
C-X-C motif chemokine ligand 10 |
increases expression |
ISO |
manganese chloride results in increased expression of CXCL10 mRNA |
CTD |
PMID:27427241 |
|
NCBI chr14:17,210,733...17,212,930
Ensembl chr14:17,210,733...17,212,930
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G |
Cxcl12 |
C-X-C motif chemokine ligand 12 |
decreases expression |
EXP |
manganese chloride results in decreased expression of CXCL12 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr 4:149,261,044...149,273,891
Ensembl chr 4:149,261,044...149,273,891
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G |
Cxcl14 |
C-X-C motif chemokine ligand 14 |
increases expression |
ISO |
manganese chloride results in increased expression of CXCL14 mRNA |
CTD |
PMID:17175027 |
|
NCBI chr17:9,109,731...9,117,754
Ensembl chr17:9,109,731...9,117,750
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G |
Cxcl2 |
C-X-C motif chemokine ligand 2 |
increases expression |
ISO EXP |
manganese chloride results in increased expression of CXCL2 mRNA |
CTD |
PMID:17175027 PMID:28801915 |
|
NCBI chr14:18,731,346...18,733,391
Ensembl chr14:18,731,378...18,733,391
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G |
Cxcl3 |
C-X-C motif chemokine ligand 3 |
increases expression |
EXP |
manganese chloride results in increased expression of CXCL3 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr14:18,820,168...18,839,659
Ensembl chr14:18,820,168...18,839,595
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G |
Cxcl6 |
C-X-C motif chemokine ligand 6 |
increases expression |
ISO |
manganese chloride results in increased expression of CXCL6 mRNA |
CTD |
PMID:17175027 |
|
NCBI chr14:18,860,201...18,920,839
Ensembl chr14:18,860,264...18,862,407
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G |
Cxxc1 |
CXXC finger protein 1 |
increases methylation decreases expression |
ISO |
manganese chloride results in increased methylation of CXXC1 gene manganese chloride results in decreased expression of CXXC1 mRNA |
CTD |
PMID:27913844 |
|
NCBI chr18:70,192,520...70,197,871
Ensembl chr18:70,192,493...70,197,867
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G |
Cycs |
cytochrome c, somatic |
multiple interactions affects localization |
ISO |
BNIP3 protein affects the reaction [manganese chloride affects the localization of CYCS protein]; Cyclosporine inhibits the reaction [manganese chloride affects the localization of CYCS protein] SNCA protein inhibits the reaction [manganese chloride affects the localization of CYCS protein] |
CTD |
PMID:19442826 PMID:25416158 |
|
NCBI chr 4:80,331,226...80,333,326
Ensembl chr 4:80,331,227...80,333,326
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G |
Cyp11a1 |
cytochrome P450, family 11, subfamily a, polypeptide 1 |
multiple interactions increases expression decreases expression |
EXP |
manganese chloride inhibits the reaction [CYP11A1 protein results in increased chemical synthesis of Progesterone] manganese chloride results in increased expression of CYP11A1 mRNA manganese chloride results in decreased expression of CYP11A1 protein |
CTD |
PMID:12699903 PMID:25981801 PMID:28801915 |
|
NCBI chr 8:62,798,317...62,809,848
Ensembl chr 8:62,779,875...62,809,893
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G |
Cyp26b1 |
cytochrome P450, family 26, subfamily b, polypeptide 1 |
decreases expression |
EXP |
manganese chloride results in decreased expression of CYP26B1 mRNA |
CTD |
PMID:26745496 |
|
NCBI chr 4:116,261,796...116,278,615
Ensembl chr 4:116,261,796...116,278,615
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G |
Cyp4f4 |
cytochrome P450, family 4, subfamily f, polypeptide 4 |
increases methylation decreases expression |
EXP |
manganese chloride results in increased methylation of CYP4F4 gene manganese chloride results in decreased expression of CYP4F4 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr 7:14,891,062...14,907,250
Ensembl chr 7:14,891,001...14,907,305
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G |
Cyria |
CYFIP related Rac1 interactor A |
increases methylation increases expression |
EXP |
manganese chloride results in increased methylation of CYRIA gene manganese chloride results in increased expression of CYRIA mRNA |
CTD |
PMID:28801915 |
|
NCBI chr 6:37,555,167...37,661,196
Ensembl chr 6:37,555,182...37,665,064
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G |
Dach2 |
dachshund family transcription factor 2 |
increases expression |
ISO |
manganese chloride results in increased expression of DACH2 mRNA |
CTD |
PMID:17175027 |
|
NCBI chr X:84,924,570...85,484,150
Ensembl chr X:85,338,928...85,483,719
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G |
Dact1 |
dishevelled-binding antagonist of beta-catenin 1 |
decreases expression |
EXP |
manganese chloride results in decreased expression of DACT1 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr 6:93,740,440...93,751,003
Ensembl chr 6:93,740,586...93,749,809
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G |
Dbh |
dopamine beta-hydroxylase |
increases methylation |
ISO |
manganese chloride results in increased methylation of DBH gene |
CTD |
PMID:27913844 |
|
NCBI chr 3:5,709,236...5,731,895
Ensembl chr 3:5,709,236...5,731,898
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G |
Dbp |
D-box binding PAR bZIP transcription factor |
increases expression |
EXP |
manganese chloride results in increased expression of DBP mRNA |
CTD |
PMID:28511934 |
|
NCBI chr 1:101,687,896...101,692,845
Ensembl chr 1:101,687,855...101,692,846
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G |
Dcp1b |
decapping mRNA 1B |
increases expression |
EXP |
manganese chloride results in increased expression of DCP1B mRNA |
CTD |
PMID:28801915 |
|
NCBI chr 4:151,249,654...151,287,018
Ensembl chr 4:151,250,041...151,285,702
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G |
Ddit3 |
DNA-damage inducible transcript 3 |
multiple interactions increases expression |
ISO EXP |
Deferoxamine promotes the reaction [manganese chloride results in increased expression of DDIT3 protein] manganese chloride results in increased expression of DDIT3 mRNA; manganese chloride results in increased expression of DDIT3 protein [manganese chloride results in increased abundance of Manganese] which results in increased expression of DDIT3 mRNA; SNCA protein promotes the reaction [manganese chloride results in increased expression of DDIT3 mRNA]; SNCA protein promotes the reaction [manganese chloride results in increased expression of DDIT3 protein] |
CTD |
PMID:23764342 PMID:23934647 PMID:23948121 PMID:25732873 PMID:32574669 |
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NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
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G |
Defb29 |
defensin beta 29 |
increases methylation increases expression |
EXP |
manganese chloride results in increased methylation of DEFB29 gene manganese chloride results in increased expression of DEFB29 mRNA |
CTD |
PMID:28801915 |
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NCBI chr 3:148,008,820...148,014,101
Ensembl chr 3:148,008,851...148,010,176
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G |
Depp1 |
DEPP1, autophagy regulator |
increases expression |
EXP |
manganese chloride results in increased expression of DEPP1 mRNA |
CTD |
PMID:28801915 |
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NCBI chr 4:148,780,330...148,784,566
Ensembl chr 4:148,782,479...148,784,562
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G |
Dhrs3 |
dehydrogenase/reductase 3 |
decreases expression |
EXP |
manganese chloride results in decreased expression of DHRS3 mRNA |
CTD |
PMID:28801915 |
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NCBI chr 5:162,809,090...162,843,385
Ensembl chr 5:162,808,646...162,843,383
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G |
Dld |
dihydrolipoamide dehydrogenase |
decreases expression |
EXP |
manganese chloride results in decreased expression of DLD protein |
CTD |
PMID:25981801 |
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NCBI chr 6:50,597,677...50,618,694
Ensembl chr 6:50,597,677...50,618,694
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G |
Dlk1 |
delta like non-canonical Notch ligand 1 |
increases methylation decreases expression |
ISO |
manganese chloride results in increased methylation of DLK1 gene manganese chloride results in decreased expression of DLK1 mRNA |
CTD |
PMID:27913844 |
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NCBI chr 6:133,576,513...133,583,751
Ensembl chr 6:133,552,821...133,583,751
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G |
Dll4 |
delta like canonical Notch ligand 4 |
increases expression |
ISO |
manganese chloride results in increased expression of DLL4 mRNA |
CTD |
PMID:17467022 |
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NCBI chr 3:111,135,011...111,146,746
Ensembl chr 3:111,135,021...111,145,986
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G |
Dmkn |
dermokine |
increases expression |
EXP |
manganese chloride results in increased expression of DMKN mRNA |
CTD |
PMID:28801915 |
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NCBI chr 1:89,215,266...89,229,696
Ensembl chr 1:89,215,266...89,229,696
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G |
Dnah14 |
dynein axonemal heavy chain 14 |
decreases expression |
ISO |
manganese chloride results in decreased expression of DNAH14 mRNA |
CTD |
PMID:17175027 |
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NCBI chr13:99,886,373...100,072,674 NCBI chr13:101,936,210...101,973,640
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G |
Dnai2 |
dynein, axonemal, intermediate chain 2 |
decreases expression |
EXP |
manganese chloride results in decreased expression of DNAI2 mRNA |
CTD |
PMID:28801915 |
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NCBI chr10:103,266,343...103,301,521
Ensembl chr10:103,266,296...103,301,544
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G |
Dnajc12 |
DnaJ heat shock protein family (Hsp40) member C12 |
increases expression |
EXP |
manganese chloride results in increased expression of DNAJC12 mRNA |
CTD |
PMID:28801915 |
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NCBI chr20:26,893,139...26,913,041
Ensembl chr20:26,893,016...26,913,016
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G |
Dnajc16 |
DnaJ heat shock protein family (Hsp40) member C16 |
increases expression |
EXP |
manganese chloride results in increased expression of DNAJC16 mRNA |
CTD |
PMID:28801915 |
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NCBI chr 5:160,325,088...160,352,874
Ensembl chr 5:160,325,107...160,352,927
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G |
Dnph1 |
2'-deoxynucleoside 5'-phosphate N-hydrolase 1 |
decreases expression |
ISO |
manganese chloride results in decreased expression of DNPH1 mRNA |
CTD |
PMID:17175027 |
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NCBI chr 9:16,845,764...16,848,514
Ensembl chr 9:16,845,525...16,848,503
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G |
Doc2a |
double C2 domain alpha |
increases expression |
EXP |
manganese chloride results in increased expression of DOC2A mRNA |
CTD |
PMID:28801915 |
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NCBI chr 1:198,282,828...198,288,611
Ensembl chr 1:198,284,473...198,288,113
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G |
Dpep1 |
dipeptidase 1 |
decreases expression |
EXP |
manganese chloride results in decreased expression of DPEP1 mRNA |
CTD |
PMID:28801915 |
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NCBI chr19:55,973,447...55,998,830
Ensembl chr19:55,982,740...55,998,208
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G |
Dpep2 |
dipeptidase 2 |
increases expression |
EXP |
manganese chloride results in increased expression of DPEP2 mRNA |
CTD |
PMID:28801915 |
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NCBI chr19:37,964,098...37,975,154
Ensembl chr19:37,964,105...37,970,537
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G |
Dph1 |
diphthamide biosynthesis 1 |
increases expression |
EXP |
manganese chloride results in increased expression of DPH1 mRNA |
CTD |
PMID:28801915 |
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NCBI chr10:62,019,379...62,032,384
Ensembl chr10:62,019,379...62,032,407
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G |
Dpp4 |
dipeptidylpeptidase 4 |
increases expression |
ISO |
manganese chloride results in increased expression of DPP4 mRNA |
CTD |
PMID:17175027 |
|
NCBI chr 3:48,291,055...48,372,672
Ensembl chr 3:48,291,055...48,372,672
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G |
Dpysl3 |
dihydropyrimidinase-like 3 |
decreases expression increases expression |
ISO EXP |
manganese chloride results in decreased expression of DPYSL3 mRNA manganese chloride results in increased expression of DPYSL3 mRNA |
CTD |
PMID:22407947 PMID:25698507 PMID:28801915 |
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NCBI chr18:37,716,371...37,819,347
Ensembl chr18:37,716,143...37,819,097
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G |
Dr1 |
down-regulator of transcription 1 |
decreases expression |
ISO |
manganese chloride results in decreased expression of DR1 mRNA |
CTD |
PMID:17175027 |
|
NCBI chr14:2,463,651...2,475,004
Ensembl chr14:2,463,643...2,474,780 Ensembl chr14:2,463,643...2,474,780
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G |
Drd1 |
dopamine receptor D1 |
decreases expression multiple interactions increases expression |
ISO EXP |
manganese chloride results in decreased expression of DRD1 protein [manganese chloride co-treated with Iron deficiency] results in decreased expression of DRD1 protein manganese chloride results in increased expression of DRD1 Melatonin inhibits the reaction [manganese chloride results in decreased expression of DRD1 protein] |
CTD |
PMID:22479410 PMID:23458069 PMID:23604964 PMID:24969583 |
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NCBI chr17:11,099,736...11,104,352
Ensembl chr17:11,101,306...11,103,541
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G |
Drd2 |
dopamine receptor D2 |
multiple interactions decreases expression increases expression |
EXP ISO |
[manganese chloride co-treated with Iron deficiency] results in increased expression of DRD2 protein; manganese chloride inhibits the reaction [DRD2 protein binds to Spiperone] Melatonin promotes the reaction [manganese chloride results in decreased expression of DRD2 protein] manganese chloride results in increased expression of DRD2; manganese chloride results in increased expression of DRD2 protein; manganese chloride results in increased expression of DRD2 protein alternative form |
CTD |
PMID:21484877 PMID:22479410 PMID:23458069 PMID:24969583 |
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NCBI chr 8:53,678,777...53,743,643
Ensembl chr 8:53,678,777...53,743,642
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G |
Dscaml1 |
DS cell adhesion molecule-like 1 |
increases expression |
EXP |
manganese chloride results in increased expression of DSCAML1 mRNA |
CTD |
PMID:26745496 |
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NCBI chr 8:49,733,835...50,056,115
Ensembl chr 8:49,737,798...50,055,560
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G |
Dspp |
dentin sialophosphoprotein |
increases expression |
ISO |
manganese chloride results in increased expression of DSPP mRNA |
CTD |
PMID:17175027 |
|
NCBI chr14:6,926,972...6,933,079
Ensembl chr14:6,926,976...6,933,070
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G |
Dtx1 |
deltex E3 ubiquitin ligase 1 |
increases expression |
EXP |
manganese chloride results in increased expression of DTX1 mRNA |
CTD |
PMID:28801915 |
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NCBI chr12:41,383,885...41,415,783
Ensembl chr12:41,385,241...41,414,754
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G |
Dusp13 |
dual specificity phosphatase 13 |
increases expression |
EXP |
manganese chloride results in increased expression of DUSP13 mRNA |
CTD |
PMID:28801915 |
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NCBI chr15:2,524,435...2,541,734
Ensembl chr15:2,526,368...2,541,729 Ensembl chr15:2,526,368...2,541,729 Ensembl chr15:2,526,368...2,541,729 Ensembl chr15:2,526,368...2,541,729
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G |
Dusp2 |
dual specificity phosphatase 2 |
increases expression |
EXP |
manganese chloride results in increased expression of DUSP2 mRNA |
CTD |
PMID:28801915 |
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NCBI chr 3:119,776,925...119,779,110
Ensembl chr 3:119,776,925...119,779,099
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G |
Dusp4 |
dual specificity phosphatase 4 |
increases expression |
EXP |
manganese chloride results in increased expression of DUSP4 mRNA |
CTD |
PMID:28801915 |
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NCBI chr16:61,080,767...61,090,973
Ensembl chr16:61,078,175...61,091,169
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G |
Dusp5 |
dual specificity phosphatase 5 |
increases expression increases methylation |
EXP |
manganese chloride results in increased expression of DUSP5 mRNA manganese chloride results in increased methylation of DUSP5 gene |
CTD |
PMID:28801915 |
|
NCBI chr 1:274,245,184...274,258,595
Ensembl chr 1:274,245,184...274,258,595
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G |
Dusp6 |
dual specificity phosphatase 6 |
increases methylation increases expression |
EXP |
manganese chloride results in increased methylation of DUSP6 gene manganese chloride results in increased expression of DUSP6 mRNA |
CTD |
PMID:28801915 |
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NCBI chr 7:41,475,163...41,479,393
Ensembl chr 7:41,475,163...41,479,392
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G |
Dynlt4 |
dynein light chain Tctex-type 4 |
increases expression |
EXP |
manganese chloride results in increased expression of DYNLT4 mRNA |
CTD |
PMID:28801915 |
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NCBI chr 5:135,995,128...135,997,807
Ensembl chr 5:135,997,052...135,997,711
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G |
Eaf2 |
ELL associated factor 2 |
increases expression increases methylation |
EXP |
manganese chloride results in increased expression of EAF2 mRNA manganese chloride results in increased methylation of EAF2 gene |
CTD |
PMID:28801915 |
|
NCBI chr11:66,878,658...66,923,092
Ensembl chr11:66,878,658...66,923,092
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G |
Ebi3 |
Epstein-Barr virus induced 3 |
increases expression |
EXP |
manganese chloride results in increased expression of EBI3 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr 9:11,110,874...11,114,843
Ensembl chr 9:11,110,874...11,114,843
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G |
Ecrg4 |
ECRG4 augurin precursor |
decreases expression |
EXP |
manganese chloride results in decreased expression of ECRG4 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr 9:50,526,811...50,548,056
Ensembl chr 9:50,526,811...50,548,046
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G |
Edn1 |
endothelin 1 |
decreases expression |
EXP |
manganese chloride results in decreased expression of EDN1 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324
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G |
Egf |
epidermal growth factor |
multiple interactions |
ISO |
[manganese chloride co-treated with EGF protein] results in increased activity of EGFR protein |
CTD |
PMID:2354210 |
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NCBI chr 2:68,820,616...68,895,537
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G |
Egfl7 |
EGF-like-domain, multiple 7 |
increases expression |
ISO |
manganese chloride results in increased expression of EGFL7 mRNA |
CTD |
PMID:17467022 |
|
NCBI chr 3:4,034,759...4,044,280
Ensembl chr 3:4,034,921...4,043,936
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G |
Egfr |
epidermal growth factor receptor |
multiple interactions increases expression increases activity |
ISO EXP |
[manganese chloride co-treated with EGF protein] results in increased activity of EGFR protein manganese chloride results in increased expression of EGFR mRNA manganese chloride results in increased activity of EGFR protein |
CTD |
PMID:2354210 PMID:28801915 |
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NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796
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G |
Egln3 |
egl-9 family hypoxia-inducible factor 3 |
increases expression |
EXP |
manganese chloride results in increased expression of EGLN3 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr 6:75,050,329...75,075,795
Ensembl chr 6:75,050,329...75,075,795
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G |
Egr1 |
early growth response 1 |
increases expression |
EXP ISO |
manganese chloride results in increased expression of EGR1 mRNA |
CTD |
PMID:28801915 |
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NCBI chr18:27,657,903...27,660,101
Ensembl chr18:27,657,628...27,661,429
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G |
Egr2 |
early growth response 2 |
increases expression |
ISO EXP |
manganese chloride results in increased expression of EGR2 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr20:22,452,170...22,461,018
Ensembl chr20:22,454,463...22,459,025
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G |
Egr3 |
early growth response 3 |
increases expression |
EXP |
manganese chloride results in increased expression of EGR3 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr15:51,756,683...51,762,080
Ensembl chr15:51,756,736...51,760,722
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G |
Eif1ad |
eukaryotic translation initiation factor 1A domain containing |
increases expression |
EXP |
manganese chloride results in increased expression of EIF1AD mRNA |
CTD |
PMID:28801915 |
|
NCBI chr 1:220,746,387...220,751,687
Ensembl chr 1:220,746,387...220,751,684
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G |
Eif2a |
eukaryotic translation initiation factor 2A |
multiple interactions |
EXP |
manganese chloride results in increased expression of and results in increased phosphorylation of EIF2A protein; SNCA protein promotes the reaction [manganese chloride results in increased expression of and results in increased phosphorylation of EIF2A protein] |
CTD |
PMID:23934647 |
|
NCBI chr 2:148,722,343...148,755,781
Ensembl chr 2:148,722,231...148,755,520
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G |
Eif2ak2 |
eukaryotic translation initiation factor 2-alpha kinase 2 |
multiple interactions |
EXP |
[manganese chloride results in increased abundance of Manganese] which results in increased cleavage of EIF2AK2 protein; GW 506033X inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased cleavage of EIF2AK2 protein]; pyrazolanthrone inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased cleavage of EIF2AK2 protein] |
CTD |
PMID:32574669 |
|
NCBI chr 6:1,428,845...1,466,193
Ensembl chr 6:1,428,834...1,466,201
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G |
Eif2ak3 |
eukaryotic translation initiation factor 2 alpha kinase 3 |
multiple interactions increases expression increases phosphorylation |
EXP |
[manganese chloride results in increased abundance of Manganese] which results in increased phosphorylation of EIF2AK3 protein; manganese chloride promotes the reaction [EIF2AK3 protein results in increased expression of ATF4 mRNA]; manganese chloride promotes the reaction [EIF2AK3 protein results in increased phosphorylation of EIF2S1 protein]; manganese chloride results in increased expression of and results in increased phosphorylation of EIF2AK3 protein; SNCA protein promotes the reaction [manganese chloride results in increased expression of and results in increased phosphorylation of EIF2AK3 protein] manganese chloride results in increased expression of EIF2AK3 protein manganese chloride results in increased phosphorylation of EIF2AK3 protein |
CTD |
PMID:23934647 PMID:23948121 PMID:25732873 PMID:32574669 |
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NCBI chr 4:98,648,513...98,709,695
Ensembl chr 4:98,648,545...98,709,694
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G |
Eif2s1 |
eukaryotic translation initiation factor 2 subunit alpha |
increases phosphorylation multiple interactions |
ISO EXP |
manganese chloride results in increased phosphorylation of EIF2S1 protein [manganese chloride results in increased abundance of Manganese] which results in increased phosphorylation of EIF2S1 protein; manganese chloride promotes the reaction [EIF2AK3 protein results in increased phosphorylation of EIF2S1 protein] |
CTD |
PMID:23764342 PMID:23948121 PMID:32574669 |
|
NCBI chr 6:102,048,372...102,073,041
Ensembl chr 6:102,048,372...102,073,041
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G |
Eif4ebp1 |
eukaryotic translation initiation factor 4E binding protein 1 |
multiple interactions decreases phosphorylation |
ISO |
corynoxine B promotes the reaction [manganese chloride results in decreased phosphorylation of EIF4EBP1 protein] |
CTD |
PMID:30578841 |
|
NCBI chr16:68,954,860...68,968,248
Ensembl chr16:68,954,875...68,968,248
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G |
Elf1 |
E74 like ETS transcription factor 1 |
decreases expression |
ISO |
manganese chloride results in decreased expression of ELF1 mRNA |
CTD |
PMID:17175027 |
|
NCBI chr15:61,772,544...61,868,442
Ensembl chr15:61,826,711...61,868,343
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G |
Elk3 |
ETS transcription factor ELK3 |
increases expression |
ISO |
manganese chloride results in increased expression of ELK3 mRNA |
CTD |
PMID:17467022 |
|
NCBI chr 7:34,086,213...34,149,601
Ensembl chr 7:34,086,220...34,121,694
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G |
Elmod3 |
ELMO domain containing 3 |
increases expression |
EXP |
manganese chloride results in increased expression of ELMOD3 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr 4:100,422,256...100,465,152
Ensembl chr 4:100,422,252...100,465,112
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G |
Elovl6 |
ELOVL fatty acid elongase 6 |
decreases expression |
EXP |
manganese chloride results in decreased expression of ELOVL6 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr 2:234,187,490...234,296,124
Ensembl chr 2:234,189,105...234,296,145 Ensembl chr 2:234,189,105...234,296,145
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G |
Eml2 |
EMAP like 2 |
increases expression |
ISO |
manganese chloride results in increased expression of EML2 mRNA |
CTD |
PMID:17175027 |
|
NCBI chr 1:80,087,684...80,118,784
Ensembl chr 1:80,087,684...80,119,012
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G |
Enc1 |
ectodermal-neural cortex 1 |
decreases expression |
EXP |
manganese chloride results in decreased expression of ENC1 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr 2:28,049,217...28,061,023
Ensembl chr 2:28,049,217...28,061,029
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G |
Eng |
endoglin |
increases expression |
ISO |
manganese chloride results in increased expression of ENG mRNA |
CTD |
PMID:17467022 |
|
NCBI chr 3:11,679,530...11,717,486
Ensembl chr 3:11,679,530...11,717,485
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G |
Eno2 |
enolase 2 |
increases expression multiple interactions decreases expression |
EXP ISO |
manganese chloride results in increased expression of ENO2 mRNA Melatonin inhibits the reaction [manganese chloride results in decreased expression of ENO2 protein] |
CTD |
PMID:22281203 PMID:24969583 |
|
NCBI chr 4:157,285,192...157,294,090
Ensembl chr 4:157,285,179...157,294,047 Ensembl chr 9:157,285,179...157,294,047
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G |
Eomes |
eomesodermin |
decreases expression |
ISO |
manganese chloride results in decreased expression of EOMES mRNA; manganese chloride results in decreased expression of EOMES protein |
CTD |
PMID:25698507 |
|
NCBI chr 8:127,144,367...127,152,618
Ensembl chr 8:127,144,903...127,151,493
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G |
Epas1 |
endothelial PAS domain protein 1 |
increases expression |
ISO |
manganese chloride results in increased expression of EPAS1 mRNA |
CTD |
PMID:17467022 |
|
NCBI chr 6:10,306,508...10,385,239
Ensembl chr 6:10,306,405...10,387,265
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G |
Epdr1 |
ependymin related 1 |
increases expression |
EXP |
manganese chloride results in increased expression of EPDR1 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr17:47,397,558...47,422,183
Ensembl chr17:47,397,558...47,422,182
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G |
Epha2 |
Eph receptor A2 |
increases expression |
EXP |
manganese chloride results in increased expression of EPHA2 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr 5:159,845,773...159,874,203
Ensembl chr 5:159,845,774...159,874,206
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G |
Epha4 |
Eph receptor A4 |
increases methylation decreases expression |
EXP |
manganese chloride results in increased methylation of EPHA4 gene manganese chloride results in decreased expression of EPHA4 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr 9:83,111,222...83,253,486
Ensembl chr 9:83,111,222...83,253,458
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G |
Erap1 |
endoplasmic reticulum aminopeptidase 1 |
increases expression |
ISO |
manganese chloride results in increased expression of ERAP1 mRNA |
CTD |
PMID:17467022 |
|
NCBI chr 2:1,410,877...1,449,734
Ensembl chr 2:1,410,934...1,449,733
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G |
Ercc6l |
ERCC excision repair 6 like, spindle assembly checkpoint helicase |
decreases expression |
ISO |
manganese chloride results in decreased expression of ERCC6L mRNA |
CTD |
PMID:17175027 |
|
NCBI chr X:72,018,373...72,034,140
Ensembl chr X:72,018,373...72,034,099
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G |
Ereg |
epiregulin |
increases expression |
ISO |
manganese chloride results in increased expression of EREG mRNA |
CTD |
PMID:17175027 |
|
NCBI chr14:18,577,620...18,591,395
Ensembl chr14:18,576,355...18,591,394
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G |
Erich1 |
glutamate-rich 1 |
increases expression |
ISO |
manganese chloride results in increased expression of ERICH1 mRNA |
CTD |
PMID:17175027 |
|
NCBI chr16:80,601,873...80,667,774
Ensembl chr16:80,601,973...80,667,781
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G |
Ern1 |
endoplasmic reticulum to nucleus signaling 1 |
multiple interactions increases phosphorylation |
EXP |
SNCA protein promotes the reaction [manganese chloride results in increased phosphorylation of ERN1 protein] |
CTD |
PMID:23934647 PMID:25732873 |
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NCBI chr10:94,588,555...94,682,072
Ensembl chr10:94,588,555...94,681,914
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G |
Errfi1 |
ERBB receptor feedback inhibitor 1 |
increases expression |
EXP |
manganese chloride results in increased expression of ERRFI1 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr 5:167,951,564...167,966,011
Ensembl chr 5:167,952,728...167,966,009
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G |
Esr1 |
estrogen receptor 1 |
multiple interactions decreases expression |
ISO |
Estradiol inhibits the reaction [manganese chloride results in decreased expression of ESR1 protein]; Tamoxifen inhibits the reaction [manganese chloride results in decreased expression of ESR1 protein] |
CTD |
PMID:29183790 |
|
NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
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G |
Etv3 |
ETS variant transcription factor 3 |
increases expression |
EXP |
manganese chloride results in increased expression of ETV3 mRNA |
CTD |
PMID:28801915 |
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NCBI chr 2:186,872,483...186,887,294
Ensembl chr 2:186,872,520...186,886,592
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G |
Etv4 |
ETS variant transcription factor 4 |
increases expression |
EXP |
manganese chloride results in increased expression of ETV4 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr10:89,685,058...89,700,300
Ensembl chr10:89,685,058...89,700,283
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G |
Etv5 |
ETS variant transcription factor 5 |
increases expression |
EXP |
manganese chloride results in increased expression of ETV5 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr11:82,194,657...82,252,145
Ensembl chr11:82,194,657...82,252,139
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G |
Eva1c |
eva-1 homolog C |
increases expression |
EXP |
manganese chloride results in increased expression of EVA1C mRNA |
CTD |
PMID:28801915 |
|
NCBI chr11:31,001,697...31,075,784
Ensembl chr11:31,002,451...31,075,809
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G |
Exoc6 |
exocyst complex component 6 |
decreases expression |
ISO |
manganese chloride results in decreased expression of EXOC6 mRNA |
CTD |
PMID:17175027 |
|
NCBI chr 1:256,211,879...256,369,318
Ensembl chr 1:256,226,179...256,368,813
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G |
Eya4 |
EYA transcriptional coactivator and phosphatase 4 |
decreases expression |
ISO |
manganese chloride results in decreased expression of EYA4 mRNA |
CTD |
PMID:17175027 |
|
NCBI chr 1:23,237,617...23,611,580
Ensembl chr 1:23,409,408...23,610,164
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G |
F2rl1 |
F2R like trypsin receptor 1 |
increases expression |
EXP |
manganese chloride results in increased expression of F2RL1 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr 2:25,222,324...25,235,275
Ensembl chr 2:25,222,328...25,235,275
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G |
Fa2h |
fatty acid 2-hydroxylase |
increases expression decreases expression |
EXP |
manganese chloride results in increased expression of FA2H mRNA manganese chloride results in decreased expression of FA2H mRNA |
CTD |
PMID:26745496 PMID:28801915 |
|
NCBI chr19:43,545,380...43,596,788
Ensembl chr19:43,545,378...43,596,801
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G |
Fads2 |
fatty acid desaturase 2 |
decreases expression |
EXP |
manganese chloride results in decreased expression of FADS2 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr 1:225,906,582...226,152,568
Ensembl chr 1:226,114,413...226,152,524
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G |
Fam107a |
family with sequence similarity 107, member A |
decreases expression |
EXP |
manganese chloride results in decreased expression of FAM107A mRNA |
CTD |
PMID:26745496 |
|
NCBI chr15:18,399,145...18,415,959
Ensembl chr15:18,399,515...18,415,965
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G |
Fam171b |
family with sequence similarity 171, member B |
increases expression |
EXP |
manganese chloride results in increased expression of FAM171B mRNA |
CTD |
PMID:28801915 |
|
NCBI chr 3:71,210,048...71,265,419
Ensembl chr 3:71,210,301...71,262,615
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G |
Fam180a |
family with sequence similarity 180, member A |
decreases expression |
EXP |
manganese chloride results in decreased expression of FAM180A mRNA |
CTD |
PMID:26745496 |
|
NCBI chr 4:62,845,054...62,860,361
Ensembl chr 4:62,844,971...62,860,446
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G |
Fam210a |
family with sequence similarity 210, member A |
increases expression |
EXP |
manganese chloride results in increased expression of FAM210A mRNA |
CTD |
PMID:28801915 |
|
NCBI chr18:64,045,023...64,084,594
Ensembl chr18:64,045,432...64,084,556
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G |
Fam210b |
family with sequence similarity 210, member B |
increases expression |
EXP |
manganese chloride results in increased expression of FAM210B mRNA |
CTD |
PMID:28801915 |
|
NCBI chr 3:170,354,109...170,364,265
Ensembl chr 3:170,354,141...170,362,513
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G |
Fam219a |
family with sequence similarity 219, member A |
increases expression |
EXP |
manganese chloride results in increased expression of FAM219A mRNA |
CTD |
PMID:28801915 |
|
NCBI chr 5:57,896,824...57,947,569
Ensembl chr 5:57,897,368...57,947,183
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G |
Fam227a |
family with sequence similarity 227, member A |
increases expression |
EXP |
manganese chloride results in increased expression of FAM227A mRNA |
CTD |
PMID:28801915 |
|
NCBI chr 7:120,846,166...120,891,738
Ensembl chr 7:120,846,330...120,882,392
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G |
Fam229b |
family with sequence similarity 229, member B |
increases expression |
EXP |
manganese chloride results in increased expression of FAM229B mRNA |
CTD |
PMID:28801915 |
|
NCBI chr20:44,207,463...44,220,777
Ensembl chr20:44,207,478...44,220,702
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G |
Fam71f1 |
family with sequence similarity 71, member F1 |
increases expression |
EXP |
manganese chloride results in increased expression of FAM71F1 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr 4:56,591,719...56,615,157
Ensembl chr 4:56,591,715...56,615,158
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G |
Fancf |
FA complementation group F |
decreases expression |
ISO |
manganese chloride results in decreased expression of FANCF mRNA |
CTD |
PMID:17175027 |
|
NCBI chr 1:107,229,516...107,232,321
Ensembl chr 1:107,231,292...107,232,305
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G |
Fas |
Fas cell surface death receptor |
increases expression |
EXP |
manganese chloride results in increased expression of FAS mRNA |
CTD |
PMID:28801915 |
|
NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790
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G |
Faslg |
Fas ligand |
increases expression multiple interactions |
EXP |
manganese chloride results in increased expression of FASLG protein bafilomycin A1 inhibits the reaction [manganese chloride results in increased expression of FASLG protein]; CA 074 methyl ester inhibits the reaction [manganese chloride results in increased expression of FASLG protein]; pepstatin inhibits the reaction [manganese chloride results in increased expression of FASLG protein] |
CTD |
PMID:21704098 PMID:28378122 |
|
NCBI chr13:79,696,811...79,717,581
Ensembl chr13:79,698,445...79,705,705
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G |
Fasn |
fatty acid synthase |
decreases expression |
EXP |
manganese chloride results in decreased expression of FASN mRNA |
CTD |
PMID:28801915 |
|
NCBI chr10:109,987,735...110,005,901
Ensembl chr10:109,987,735...110,005,901
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|
G |
Fat2 |
FAT atypical cadherin 2 |
increases methylation |
EXP |
manganese chloride results in increased methylation of FAT2 gene |
CTD |
PMID:28801915 |
|
NCBI chr10:40,583,025...40,682,598
Ensembl chr10:40,584,403...40,657,861
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|
G |
Fat4 |
FAT atypical cadherin 4 |
decreases expression |
EXP |
manganese chloride results in decreased expression of FAT4 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr 2:125,751,818...125,879,398
Ensembl chr 2:125,752,130...125,879,387 Ensembl chr 2:125,752,130...125,879,387
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|
G |
Fbln2 |
fibulin 2 |
increases expression |
EXP |
manganese chloride results in increased expression of FBLN2 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr 4:122,835,237...122,895,127
Ensembl chr 4:122,835,436...122,895,121
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G |
Fbn1 |
fibrillin 1 |
increases expression |
EXP |
manganese chloride results in increased expression of FBN1 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr 3:117,569,708...117,766,160
Ensembl chr 3:117,569,697...117,766,120
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G |
Fbp2 |
fructose-bisphosphatase 2 |
increases expression |
EXP |
manganese chloride results in increased expression of FBP2 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr17:372,554...389,918
Ensembl chr17:372,551...389,967
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|
G |
Fbxl2 |
F-box and leucine-rich repeat protein 2 |
increases expression |
EXP |
manganese chloride results in increased expression of FBXL2 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr 8:122,240,393...122,290,439
Ensembl chr 8:122,243,016...122,311,431
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|
G |
Fbxl4 |
F-box and leucine-rich repeat protein 4 |
increases expression |
EXP |
manganese chloride results in increased expression of FBXL4 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr 5:36,555,061...36,628,920
Ensembl chr 5:36,555,109...36,629,689
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G |
Fcgr1a |
Fc fragment of IgG receptor Ia |
decreases expression |
EXP |
manganese chloride results in decreased expression of FCGR1A mRNA |
CTD |
PMID:26745496 |
|
NCBI chr 2:198,430,536...198,439,453
Ensembl chr 2:198,430,530...198,458,041
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G |
Fcgr3a |
Fc fragment of IgG receptor IIIa |
increases expression |
EXP |
manganese chloride results in increased expression of FCGR3A mRNA |
CTD |
PMID:28801915 |
|
NCBI chr13:89,385,775...89,396,047
Ensembl chr13:89,385,859...89,396,051
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G |
Fdps |
farnesyl diphosphate synthase |
decreases expression |
EXP |
manganese chloride results in decreased expression of FDPS mRNA |
CTD |
PMID:28801915 |
|
NCBI chr 2:188,403,595...188,413,219
Ensembl chr 2:188,392,858...188,413,219
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G |
Fez1 |
fasciculation and elongation protein zeta 1 |
increases expression |
EXP |
manganese chloride results in increased expression of FEZ1 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr 8:39,305,128...39,350,270
Ensembl chr 8:39,305,128...39,350,270
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G |
Fez2 |
fasciculation and elongation protein zeta 2 |
increases expression |
EXP |
manganese chloride results in increased expression of FEZ2 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr 6:963,903...1,003,955
Ensembl chr 6:963,907...1,004,001
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G |
Fgf2 |
fibroblast growth factor 2 |
decreases expression increases methylation |
ISO EXP |
manganese chloride results in decreased expression of FGF2 mRNA manganese chloride results in increased methylation of FGF2 gene |
CTD |
PMID:28801915 |
|
NCBI chr 2:124,081,072...124,134,133
Ensembl chr 2:124,081,072...124,134,681
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G |
Fgf20 |
fibroblast growth factor 20 |
increases expression |
ISO |
manganese chloride results in increased expression of FGF20 mRNA |
CTD |
PMID:28986288 |
|
NCBI chr16:55,152,748...55,159,352
Ensembl chr16:55,152,748...55,159,352
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G |
Fgfbp1 |
fibroblast growth factor binding protein 1 |
decreases expression |
EXP |
manganese chloride results in decreased expression of FGFBP1 mRNA |
CTD |
PMID:26745496 |
|
NCBI chr14:71,647,429...71,650,359
Ensembl chr14:71,649,274...71,650,354
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G |
Fgfr2 |
fibroblast growth factor receptor 2 |
decreases expression |
EXP |
manganese chloride results in decreased expression of FGFR2 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr 1:200,590,951...200,696,946
Ensembl chr 1:200,590,953...200,696,928
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|
G |
Fhip2b |
FHF complex subunit HOOK interacting protein 2B |
increases expression |
EXP |
manganese chloride results in increased expression of FHIP2B mRNA |
CTD |
PMID:28801915 |
|
NCBI chr15:52,271,495...52,288,938
Ensembl chr15:52,271,496...52,288,893
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G |
Fhl1 |
four and a half LIM domains 1 |
decreases expression |
ISO |
manganese chloride results in decreased expression of FHL1 mRNA |
CTD |
PMID:17175027 |
|
NCBI chr X:159,112,516...159,172,528
Ensembl chr X:159,112,880...159,172,524
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G |
Flcn |
folliculin |
increases expression |
ISO |
manganese chloride results in increased expression of FLCN mRNA |
CTD |
PMID:17175027 |
|
NCBI chr10:46,153,185...46,172,331
Ensembl chr10:46,153,188...46,172,309
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G |
Flrt2 |
fibronectin leucine rich transmembrane protein 2 |
increases expression |
EXP |
manganese chloride results in increased expression of FLRT2 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr 6:119,518,459...119,613,534
Ensembl chr 6:119,519,714...119,609,296
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G |
Flt1 |
Fms related receptor tyrosine kinase 1 |
increases expression |
ISO |
manganese chloride results in increased expression of FLT1 mRNA |
CTD |
PMID:17467022 |
|
NCBI chr12:9,033,993...9,205,886
Ensembl chr12:9,034,308...9,205,905
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G |
Flvcr2 |
FLVCR heme transporter 2 |
decreases expression |
EXP |
manganese chloride results in decreased expression of FLVCR2 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr 6:109,617,348...109,681,495
Ensembl chr 6:109,617,355...109,681,495
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G |
Fmo2 |
flavin containing dimethylaniline monoxygenase 2 |
increases expression |
EXP |
manganese chloride results in increased expression of FMO2 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr13:80,752,526...80,775,264
Ensembl chr13:80,755,058...80,775,264
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G |
Fmo5 |
flavin containing dimethylaniline monoxygenase 5 |
decreases methylation increases expression |
EXP |
manganese chloride results in decreased methylation of FMO5 gene manganese chloride results in increased expression of FMO5 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr 2:199,796,870...199,823,927
Ensembl chr 2:199,796,881...199,823,927
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G |
Fn1 |
fibronectin 1 |
multiple interactions increases expression |
EXP |
[Buthionine Sulfoximine results in decreased abundance of Glutathione] promotes the reaction [manganese chloride results in increased expression of and results in increased secretion of FN1 protein]; [S-ethyl glutathione results in increased abundance of Glutathione] inhibits the reaction [manganese chloride results in increased expression of and results in increased secretion of FN1 protein]; [S-ethyl glutathione results in increased abundance of Glutathione] inhibits the reaction [manganese chloride results in increased expression of FN1 mRNA]; manganese chloride results in increased expression of and results in increased secretion of FN1 protein; Melatonin inhibits the reaction [manganese chloride results in increased expression of and results in increased secretion of FN1 protein]; Melatonin inhibits the reaction [manganese chloride results in increased expression of FN1 mRNA]; phenyl-N-tert-butylnitrone inhibits the reaction [manganese chloride results in increased expression of FN1 mRNA] |
CTD |
PMID:19524604 |
|
NCBI chr 9:78,900,111...78,969,018
Ensembl chr 9:78,900,103...78,969,078
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G |
Fos |
Fos proto-oncogene, AP-1 transcription factor subunit |
increases expression decreases expression |
EXP ISO |
manganese chloride results in increased expression of FOS protein manganese chloride results in decreased expression of FOS protein |
CTD |
PMID:9751194 PMID:25698507 |
|
NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
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G |
Fosl1 |
FOS like 1, AP-1 transcription factor subunit |
increases expression |
EXP |
manganese chloride results in increased expression of FOSL1 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr 1:220,826,560...220,835,066
Ensembl chr 1:220,826,560...220,835,066
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G |
Foxn4 |
forkhead box N4 |
increases expression |
EXP |
manganese chloride results in increased expression of FOXN4 mRNA |
CTD |
PMID:26745496 |
|
NCBI chr12:48,101,012...48,121,281
Ensembl chr12:48,101,673...48,121,270
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G |
Foxp2 |
forkhead box P2 |
increases expression |
ISO |
manganese chloride results in increased expression of FOXP2 mRNA |
CTD |
PMID:17175027 |
|
NCBI chr 4:41,364,441...41,944,685
Ensembl chr 4:41,364,441...41,942,023
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G |
Frem3 |
FRAS1 related extracellular matrix 3 |
increases expression |
EXP |
manganese chloride results in increased expression of FREM3 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr19:30,973,329...31,032,331
Ensembl chr19:30,973,329...31,031,817
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G |
Frmd4a |
FERM domain containing 4A |
increases expression |
EXP |
manganese chloride results in increased expression of FRMD4A mRNA |
CTD |
PMID:28801915 |
|
NCBI chr17:77,642,302...77,918,210
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|
G |
Fscn2 |
fascin actin-bundling protein 2, retinal |
decreases expression |
EXP |
manganese chloride results in decreased expression of FSCN2 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr10:109,528,307...109,540,675
Ensembl chr10:109,533,487...109,540,026
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G |
Fshb |
follicle stimulating hormone subunit beta |
multiple interactions decreases expression |
EXP |
Quercetin inhibits the reaction [manganese chloride results in decreased expression of FSHB protein] |
CTD |
PMID:28040552 |
|
NCBI chr 3:98,088,321...98,092,131
Ensembl chr 3:98,088,324...98,092,131
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|
G |
Fstl3 |
follistatin like 3 |
increases expression |
EXP |
manganese chloride results in increased expression of FSTL3 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr 7:12,806,031...12,810,556
Ensembl chr 7:12,804,919...12,810,570
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G |
Fth1 |
ferritin heavy chain 1 |
decreases expression |
EXP |
manganese chloride results in decreased expression of FTH1 mRNA; manganese chloride results in decreased expression of FTH1 protein |
CTD |
PMID:15893546 PMID:15922012 PMID:16545456 PMID:16568477 |
|
NCBI chr 1:226,030,940...226,033,228
Ensembl chr 1:226,030,938...226,033,228
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|
G |
Ftl1 |
ferritin light chain 1 |
decreases expression |
EXP |
manganese chloride results in decreased expression of FTL mRNA |
CTD |
PMID:15893546 |
|
NCBI chr 1:101,448,190...101,450,034
Ensembl chr 1:101,448,346...101,449,829
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G |
Fut1 |
fucosyltransferase 1 |
increases expression |
EXP |
manganese chloride results in increased expression of FUT1 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr 1:101,599,018...101,602,440
Ensembl chr 1:101,599,018...101,602,436
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G |
Fut2 |
fucosyltransferase 2 |
decreases expression increases methylation |
EXP |
manganese chloride results in decreased expression of FUT2 mRNA manganese chloride results in increased methylation of FUT2 gene |
CTD |
PMID:28801915 |
|
NCBI chr 1:101,631,633...101,651,668
Ensembl chr 1:101,631,635...101,651,668
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|
G |
Fxyd2 |
FXYD domain-containing ion transport regulator 2 |
increases expression |
ISO |
manganese chloride results in increased expression of FXYD2 mRNA |
CTD |
PMID:17175027 |
|
NCBI chr 8:49,710,334...49,717,492
Ensembl chr 8:49,710,477...49,716,955
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G |
G0s2 |
G0/G1switch 2 |
increases expression |
EXP |
manganese chloride results in increased expression of G0S2 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr13:112,004,140...112,005,052
Ensembl chr13:112,004,140...112,005,052
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G |
Gabbr2 |
gamma-aminobutyric acid type B receptor subunit 2 |
multiple interactions decreases expression |
EXP ISO |
[Iron deficiency co-treated with manganese chloride] results in decreased expression of GABBR2 mRNA; [Iron deficiency co-treated with manganese chloride] results in decreased expression of GABBR2 protein [manganese chloride results in increased abundance of Manganese] which results in increased expression of GABBR2 protein manganese chloride results in decreased expression of GABBR2 mRNA |
CTD |
PMID:18771689 PMID:32659473 |
|
NCBI chr 5:62,276,100...62,621,737
Ensembl chr 5:62,276,100...62,621,737
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G |
Gabra1 |
gamma-aminobutyric acid type A receptor subunit alpha 1 |
multiple interactions increases expression decreases expression |
EXP ISO |
[Iron deficiency co-treated with manganese chloride] results in increased expression of GABRA1 protein [manganese chloride results in increased abundance of Manganese] which results in decreased expression of GABRA1 protein manganese chloride results in increased expression of GABRA1 protein manganese chloride results in decreased expression of GABRA1 mRNA |
CTD |
PMID:18771689 PMID:32659473 |
|
NCBI chr10:27,310,718...27,371,802
Ensembl chr10:27,310,725...27,366,665
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G |
Gabrb3 |
gamma-aminobutyric acid type A receptor subunit beta 3 |
decreases expression |
EXP |
manganese chloride results in decreased expression of GABRB3 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr 1:113,034,251...113,265,364
Ensembl chr 1:112,976,770...113,265,364
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G |
Gabrg2 |
gamma-aminobutyric acid type A receptor subunit gamma 2 |
increases expression |
ISO |
manganese chloride results in increased expression of GABRG2 mRNA |
CTD |
PMID:17175027 |
|
NCBI chr10:27,090,913...27,179,786
Ensembl chr10:27,092,827...27,179,900
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G |
Gad1 |
glutamate decarboxylase 1 |
decreases expression |
EXP |
manganese chloride results in decreased expression of GAD1 mRNA |
CTD |
PMID:12106697 |
|
NCBI chr 3:56,861,440...56,902,139
Ensembl chr 3:56,861,396...56,902,157
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G |
Gadd45a |
growth arrest and DNA-damage-inducible, alpha |
decreases expression |
EXP |
manganese chloride results in decreased expression of GADD45A mRNA |
CTD |
PMID:28801915 |
|
NCBI chr 4:97,782,512...97,784,814
Ensembl chr 4:97,782,512...97,784,842
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G |
Gal |
galanin and GMAP prepropeptide |
increases expression |
ISO |
manganese chloride results in increased expression of GAL mRNA |
CTD |
PMID:17175027 |
|
NCBI chr 1:218,653,059...218,657,922
Ensembl chr 1:218,652,917...218,657,925
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|
G |
Gale |
UDP-galactose-4-epimerase |
decreases expression |
EXP |
manganese chloride results in decreased expression of GALE mRNA |
CTD |
PMID:28801915 |
|
NCBI chr 5:154,310,453...154,314,959
Ensembl chr 5:154,310,453...154,314,955
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|
G |
Gbe1 |
1,4-alpha-glucan branching enzyme 1 |
increases methylation decreases expression |
ISO |
manganese chloride results in increased methylation of GBE1 gene manganese chloride results in decreased expression of GBE1 mRNA |
CTD |
PMID:27913844 |
|
NCBI chr11:7,210,169...7,485,895
Ensembl chr11:7,210,209...7,485,890
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G |
Gbp5 |
guanylate binding protein 5 |
increases methylation increases expression |
EXP |
manganese chloride results in increased methylation of GBP5 gene manganese chloride results in increased expression of GBP5 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr 2:248,178,441...248,196,873
Ensembl chr 2:248,178,389...248,197,160
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G |
Gcdh |
glutaryl-CoA dehydrogenase |
decreases expression |
EXP |
manganese chloride results in decreased expression of GCDH mRNA |
CTD |
PMID:22281203 |
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NCBI chr19:26,000,497...26,006,970
Ensembl chr19:26,000,497...26,006,970
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G |
Gcfc2 |
GC-rich sequence DNA-binding factor 2 |
decreases expression |
ISO |
manganese chloride results in decreased expression of GCFC2 mRNA |
CTD |
PMID:17175027 |
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NCBI chr 4:112,662,556...112,700,505
Ensembl chr 4:112,662,609...112,699,711
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G |
Gcgr |
glucagon receptor |
decreases expression increases methylation |
EXP |
manganese chloride results in decreased expression of GCGR mRNA manganese chloride results in increased methylation of GCGR gene |
CTD |
PMID:28801915 |
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NCBI chr10:109,707,863...109,716,253
Ensembl chr10:109,707,962...109,716,128
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G |
Gch1 |
GTP cyclohydrolase 1 |
decreases expression |
EXP |
manganese chloride results in decreased expression of GCH1 mRNA |
CTD |
PMID:28801915 |
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NCBI chr15:23,935,011...23,968,971
Ensembl chr15:23,934,585...23,969,011
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G |
Gdap2 |
ganglioside-induced differentiation-associated-protein 2 |
increases expression |
ISO |
manganese chloride results in increased expression of GDAP2 mRNA |
CTD |
PMID:17175027 |
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NCBI chr 2:202,470,485...202,526,849
Ensembl chr 2:202,470,487...202,526,849
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G |
Gdf15 |
growth differentiation factor 15 |
increases expression |
ISO |
manganese chloride results in increased expression of GDF15 mRNA |
CTD |
PMID:17175027 |
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NCBI chr16:20,555,395...20,557,978
Ensembl chr16:20,555,395...20,557,978
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G |
Gdnf |
glial cell derived neurotrophic factor |
increases methylation |
ISO |
manganese chloride results in increased methylation of GDNF gene |
CTD |
PMID:27913844 |
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NCBI chr 2:56,884,181...56,912,964
Ensembl chr 2:56,887,987...56,910,238
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G |
Gfap |
glial fibrillary acidic protein |
decreases expression multiple interactions increases expression |
EXP ISO |
manganese chloride results in decreased expression of GFAP protein Melatonin inhibits the reaction [manganese chloride results in increased expression of GFAP protein] |
CTD |
PMID:12009774 PMID:12106697 PMID:24060432 PMID:24969583 PMID:25288107 PMID:28539244 |
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NCBI chr10:90,990,762...90,999,435
Ensembl chr10:90,990,762...90,999,506
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G |
Gja1 |
gap junction protein, alpha 1 |
decreases expression |
EXP |
manganese chloride results in decreased expression of GJA1 mRNA |
CTD |
PMID:28801915 |
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NCBI chr20:37,876,650...37,889,097
Ensembl chr20:37,876,650...37,889,089
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G |
Gja5 |
gap junction protein, alpha 5 |
decreases expression |
EXP |
manganese chloride results in decreased expression of GJA5 mRNA |
CTD |
PMID:26745496 |
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NCBI chr 2:199,162,745...199,184,942
Ensembl chr 2:199,162,745...199,184,939
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G |
Gja8 |
gap junction protein, alpha 8 |
increases expression |
EXP |
manganese chloride results in increased expression of GJA8 mRNA |
CTD |
PMID:28801915 |
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NCBI chr 2:199,050,854...199,052,470
Ensembl chr 2:199,050,854...199,052,470
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G |
Gjb5 |
gap junction protein, beta 5 |
increases expression |
EXP |
manganese chloride results in increased expression of GJB5 mRNA |
CTD |
PMID:28801915 |
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NCBI chr 5:145,422,034...145,440,558
Ensembl chr 5:145,422,357...145,423,172
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G |
Gkn3 |
gastrokine 3 |
decreases expression |
EXP |
manganese chloride results in decreased expression of GKN3 mRNA |
CTD |
PMID:28801915 |
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NCBI chr 4:119,181,970...119,188,356
Ensembl chr 4:119,182,135...119,188,251
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G |
Gldn |
gliomedin |
decreases expression |
EXP |
manganese chloride results in decreased expression of GLDN mRNA |
CTD |
PMID:26745496 |
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NCBI chr 8:58,870,516...58,914,605
Ensembl chr 8:58,870,516...58,914,603
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G |
Glis1 |
GLIS family zinc finger 1 |
decreases expression |
EXP |
manganese chloride results in decreased expression of GLIS1 mRNA |
CTD |
PMID:28801915 |
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NCBI chr 5:127,043,344...127,233,395
Ensembl chr 5:127,160,495...127,233,078
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G |
Glis2 |
GLIS family zinc finger 2 |
increases expression |
EXP |
manganese chloride results in increased expression of GLIS2 mRNA |
CTD |
PMID:28801915 |
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NCBI chr10:11,154,459...11,177,063
Ensembl chr10:11,154,658...11,174,861
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G |
Glt8d2 |
glycosyltransferase 8 domain containing 2 |
increases expression |
EXP |
manganese chloride results in increased expression of GLT8D2 mRNA |
CTD |
PMID:28801915 |
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NCBI chr 7:27,146,382...27,196,689
Ensembl chr 7:27,174,882...27,192,882
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G |
Glul |
glutamate-ammonia ligase |
decreases expression multiple interactions |
EXP |
manganese chloride results in decreased expression of GLUL mRNA; manganese chloride results in decreased expression of GLUL protein Riluzole inhibits the reaction [manganese chloride results in decreased expression of and results in decreased activity of GLUL protein]; Riluzole inhibits the reaction [manganese chloride results in decreased expression of GLUL mRNA] |
CTD |
PMID:19615351 |
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NCBI chr13:71,331,052...71,340,207
Ensembl chr13:71,331,052...71,340,229
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G |
Gnb4 |
G protein subunit beta 4 |
increases expression |
EXP |
manganese chloride results in increased expression of GNB4 mRNA |
CTD |
PMID:28801915 |
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NCBI chr 2:118,978,965...119,007,877
Ensembl chr 2:118,978,973...119,007,835
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G |
Gnrh1 |
gonadotropin releasing hormone 1 |
increases expression increases secretion multiple interactions |
EXP |
manganese chloride results in increased expression of GNRH1 mRNA manganese chloride results in increased secretion of GNRH1 protein 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [manganese chloride results in increased secretion of GNRH1 protein]; [manganese chloride co-treated with Calcium Chloride] results in increased secretion of GNRH1 protein; [manganese chloride results in increased chemical synthesis of Cyclic GMP] which results in increased secretion of GNRH1 protein; Bicuculline promotes the reaction [manganese chloride results in increased secretion of GNRH1 protein]; Dopamine affects the reaction [manganese chloride results in increased secretion of GNRH1 protein]; gamma-Aminobutyric Acid inhibits the reaction [manganese chloride results in increased secretion of GNRH1 protein]; Haloperidol inhibits the reaction [manganese chloride results in increased secretion of GNRH1 protein]; KT 5823 inhibits the reaction [manganese chloride results in increased secretion of GNRH1 protein]; Methylene Blue inhibits the reaction [manganese chloride results in increased secretion of GNRH1 protein] |
CTD |
PMID:17110411 PMID:17290048 PMID:18603625 PMID:21402727 |
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NCBI chr15:44,441,856...44,446,064
Ensembl chr15:44,442,555...44,442,875 Ensembl chr15:44,442,555...44,442,875
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G |
Gpnmb |
glycoprotein nmb |
increases expression |
EXP |
manganese chloride results in increased expression of GPNMB mRNA |
CTD |
PMID:28801915 |
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NCBI chr 4:78,694,447...78,715,685
Ensembl chr 4:78,694,447...78,715,683
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G |
Gpr18 |
G protein-coupled receptor 18 |
decreases expression |
EXP |
manganese chloride results in decreased expression of GPR18 mRNA |
CTD |
PMID:26745496 |
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NCBI chr15:108,323,157...108,326,907
Ensembl chr15:108,323,179...108,326,907
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G |
Gpr34 |
G protein-coupled receptor 34 |
decreases expression |
EXP |
manganese chloride results in decreased expression of GPR34 mRNA |
CTD |
PMID:26745496 |
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NCBI chr X:10,022,986...10,043,504
Ensembl chr X:10,023,489...10,031,167
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G |
Gpx1 |
glutathione peroxidase 1 |
multiple interactions decreases expression |
ISO |
Melatonin affects the reaction [manganese chloride results in decreased expression of GPX1 protein] |
CTD |
PMID:24969583 PMID:25288107 |
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NCBI chr 8:117,117,430...117,118,528
Ensembl chr 8:117,117,430...117,118,522
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G |
Grik3 |
glutamate ionotropic receptor kainate type subunit 3 |
increases methylation decreases expression |
ISO EXP |
manganese chloride results in increased methylation of GRIK3 gene manganese chloride results in decreased expression of GRIK3 mRNA |
CTD |
PMID:27913844 PMID:28801915 |
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NCBI chr 5:143,500,441...143,715,546
Ensembl chr 5:143,500,441...143,715,546
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G |
Grin1 |
glutamate ionotropic receptor NMDA type subunit 1 |
decreases expression |
EXP |
manganese chloride results in decreased expression of GRIN1 mRNA; manganese chloride results in decreased expression of GRIN1 protein |
CTD |
PMID:20175136 |
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NCBI chr 3:2,507,745...2,534,664
Ensembl chr 3:2,506,896...2,534,663
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G |
Grin2a |
glutamate ionotropic receptor NMDA type subunit 2A |
decreases expression |
EXP |
manganese chloride results in decreased expression of GRIN2A mRNA; manganese chloride results in decreased expression of GRIN2A protein |
CTD |
PMID:20175136 |
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NCBI chr10:5,707,806...6,123,568
Ensembl chr10:5,930,298...6,119,990
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G |
Grin2b |
glutamate ionotropic receptor NMDA type subunit 2B |
decreases expression |
EXP |
manganese chloride results in decreased expression of GRIN2B mRNA; manganese chloride results in decreased expression of GRIN2B protein |
CTD |
PMID:20175136 |
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NCBI chr 4:169,541,620...170,000,216
Ensembl chr 4:169,560,387...169,999,873
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G |
Gsk3b |
glycogen synthase kinase 3 beta |
multiple interactions decreases phosphorylation increases activity |
EXP |
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [manganese chloride results in decreased phosphorylation of GSK3B protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [manganese chloride results in increased activity of GSK3B protein]; [Lithium Chloride results in decreased activity of GSK3B protein] inhibits the reaction [manganese chloride results in increased phosphorylation of MAPT protein]; GSK3B protein affects the reaction [manganese chloride results in increased phosphorylation of MAPT protein]; Lithium Chloride inhibits the reaction [manganese chloride results in decreased phosphorylation of and results in increased activity of GSK3B protein]; manganese chloride results in decreased phosphorylation of and results in increased activity of GSK3B protein |
CTD |
PMID:20937724 PMID:24464479 |
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NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268
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G |
Gskip |
GSK3B interacting protein |
increases expression |
EXP |
manganese chloride results in increased expression of GSKIP mRNA |
CTD |
PMID:28801915 |
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NCBI chr 6:129,512,950...129,536,320
Ensembl chr 6:129,519,709...129,536,221
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G |
Gspt2 |
G1 to S phase transition 2 |
decreases expression |
EXP |
manganese chloride results in decreased expression of GSPT2 mRNA |
CTD |
PMID:28801915 |
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NCBI chr X:63,959,131...63,961,652
Ensembl chr X:63,954,727...63,961,613
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G |
Gsr |
glutathione-disulfide reductase |
decreases expression multiple interactions |
ISO |
manganese chloride results in decreased expression of GSR mRNA [manganese chloride results in increased abundance of Manganese] which results in decreased activity of GSR protein; Melatonin affects the reaction [manganese chloride results in decreased expression of GSR protein]; Melatonin inhibits the reaction [manganese chloride results in decreased expression of GSR protein] |
CTD |
PMID:17175027 PMID:24969583 PMID:25288107 PMID:32445656 |
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NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361
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G |
Gtf2h1 |
general transcription factor IIH subunit 1 |
decreases expression |
ISO |
manganese chloride results in decreased expression of GTF2H1 mRNA |
CTD |
PMID:17175027 |
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NCBI chr 1:102,849,618...102,877,939
Ensembl chr 1:102,849,889...102,877,944
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G |
H1f1 |
H1.1 linker histone, cluster member |
decreases expression |
EXP |
manganese chloride results in decreased expression of H1F1 mRNA |
CTD |
PMID:28801915 |
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NCBI chr17:43,614,101...43,614,844
Ensembl chr17:43,614,101...43,614,844
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G |
H1f2 |
H1.2 linker histone, cluster member |
decreases expression |
EXP |
manganese chloride results in decreased expression of H1F2 mRNA |
CTD |
PMID:28801915 |
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NCBI chr17:43,638,938...43,640,445
Ensembl chr17:43,639,749...43,640,387
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G |
H2bu1 |
H2B.U histone 1 |
decreases expression |
EXP |
manganese chloride results in decreased expression of H2BU1 mRNA |
CTD |
PMID:28801915 |
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NCBI chr10:45,296,638...45,297,385
Ensembl chr10:45,296,638...45,297,385
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G |
H3c1 |
H3 clustered histone 1 |
decreases expression |
EXP |
manganese chloride results in decreased expression of H3C1 mRNA |
CTD |
PMID:28801915 |
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NCBI chr17:43,616,206...43,616,735
Ensembl chr17:44,839,721...44,840,131 Ensembl chr17:44,839,721...44,840,131 Ensembl chr17:44,839,721...44,840,131 Ensembl chr17:44,839,721...44,840,131
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G |
Hamp |
hepcidin antimicrobial peptide |
decreases expression |
EXP |
manganese chloride results in decreased expression of HAMP mRNA |
CTD |
PMID:20635692 |
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NCBI chr 1:89,368,021...89,369,960
Ensembl chr 1:89,368,021...89,369,960
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G |
Hapln3 |
hyaluronan and proteoglycan link protein 3 |
increases expression |
EXP |
manganese chloride results in increased expression of HAPLN3 mRNA |
CTD |
PMID:28801915 |
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NCBI chr 1:140,827,279...140,845,386
Ensembl chr 1:140,827,295...140,835,151
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G |
Hat1 |
histone acetyltransferase 1 |
decreases expression |
EXP ISO |
manganese chloride results in decreased expression of HAT1 protein |
CTD |
PMID:29155171 |
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NCBI chr 3:58,022,395...58,070,067
Ensembl chr 3:58,022,238...58,070,068
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G |
Hdac2 |
histone deacetylase 2 |
increases expression |
EXP |
manganese chloride results in increased expression of HDAC2 mRNA |
CTD |
PMID:29155171 |
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NCBI chr20:43,084,870...43,108,198
Ensembl chr20:43,084,870...43,108,198
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G |
Hdac3 |
histone deacetylase 3 |
increases expression |
ISO EXP |
manganese chloride results in increased expression of HDAC3 mRNA; manganese chloride results in increased expression of HDAC3 protein |
CTD |
PMID:29155171 |
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NCBI chr18:31,073,057...31,094,347
Ensembl chr18:31,073,058...31,094,303
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G |
Hdac4 |
histone deacetylase 4 |
increases expression |
ISO EXP |
manganese chloride results in increased expression of HDAC4 mRNA; manganese chloride results in increased expression of HDAC4 protein |
CTD |
PMID:29155171 |
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NCBI chr 9:99,052,945...99,299,715
Ensembl chr 9:99,057,089...99,299,715
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G |
Hdgfl3 |
HDGF like 3 |
increases expression |
EXP |
manganese chloride results in increased expression of HDGFL3 mRNA |
CTD |
PMID:28801915 |
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NCBI chr 1:143,702,864...143,752,060
Ensembl chr 1:143,702,853...143,751,789
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G |
Heatr3 |
HEAT repeat containing 3 |
increases expression |
EXP |
manganese chloride results in increased expression of HEATR3 mRNA |
CTD |
PMID:28801915 |
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NCBI chr19:19,858,419...19,896,782
Ensembl chr19:19,858,416...19,896,421
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G |
Heph |
hephaestin |
increases expression |
ISO |
manganese chloride results in increased expression of HEPH mRNA |
CTD |
PMID:17175027 |
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NCBI chr X:65,377,313...65,658,479
Ensembl chr X:65,563,122...65,658,516
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G |
Hey1 |
hes-related family bHLH transcription factor with YRPW motif 1 |
increases expression |
EXP |
manganese chloride results in increased expression of HEY1 mRNA |
CTD |
PMID:28801915 |
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NCBI chr 2:95,320,147...95,322,701
Ensembl chr 2:95,320,283...95,322,696
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G |
Hfe |
homeostatic iron regulator |
multiple interactions decreases response to substance |
ISO |
HFE gene mutant form inhibits the reaction [manganese chloride results in decreased activity of SOD1 protein] HFE gene mutant form results in decreased susceptibility to manganese chloride |
CTD |
PMID:25874029 |
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NCBI chr17:43,661,276...43,669,327
Ensembl chr17:43,661,222...43,669,985
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G |
Hif1a |
hypoxia inducible factor 1 subunit alpha |
increases expression decreases expression decreases degradation increases stability decreases hydroxylation multiple interactions |
ISO EXP |
manganese chloride results in increased expression of HIF1A mRNA; manganese chloride results in increased expression of HIF1A protein manganese chloride results in decreased expression of HIF1A mRNA manganese chloride results in decreased degradation of HIF1A protein manganese chloride results in increased stability of HIF1A protein manganese chloride results in decreased hydroxylation of HIF1A protein 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [manganese chloride results in increased expression of and results in increased activity of HIF1A protein]; [manganese chloride results in decreased activity of P4HTM protein] which results in decreased degradation of HIF1A protein; [manganese chloride results in decreased activity of P4HTM protein] which results in decreased hydroxylation of HIF1A protein; Ascorbic Acid inhibits the reaction [manganese chloride results in decreased hydroxylation of HIF1A protein]; Ascorbic Acid inhibits the reaction [manganese chloride results in increased stability of HIF1A protein]; HIF1A mutant form inhibits the reaction [manganese chloride results in increased secretion of VEGFA protein]; Iron inhibits the reaction [manganese chloride results in increased expression of HIF1A protein]; manganese chloride inhibits the reaction [[benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with Ketoglutaric Acids co-treated with Ascorbic Acid co-treated with ferrous chloride] promotes the reaction [VHL protein binds to HIF1A protein]]; manganese chloride results in increased expression of and results in increased activity of and results in increased stability of HIF1A protein; pyrazolanthrone inhibits the reaction [manganese chloride results in increased expression of and results in increased activity of and results in increased stability of HIF1A protein]; SB 203580 inhibits the reaction [manganese chloride results in increased expression of and results in increased activity of and results in increased stability of HIF1A protein]; SB 203580 inhibits the reaction [manganese chloride results in increased expression of and results in increased activity of HIF1A protein]; VHL protein affects the reaction [manganese chloride results in increased expression of HIF1A protein] |
CTD |
PMID:17175027 PMID:17467022 PMID:19074761 PMID:19263519 PMID:20152896 PMID:28801915 |
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NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
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G |
Hif1an |
hypoxia inducible factor 1 subunit alpha inhibitor |
decreases expression |
ISO |
manganese chloride results in decreased expression of HIF1AN mRNA |
CTD |
PMID:17175027 |
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NCBI chr 1:264,309,214...264,319,269
Ensembl chr 1:264,309,214...264,319,267
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G |
Hilpda |
hypoxia inducible lipid droplet-associated |
increases expression |
EXP |
manganese chloride results in increased expression of HILPDA mRNA |
CTD |
PMID:22281203 |
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NCBI chr 4:56,547,600...56,550,584
Ensembl chr 4:56,549,739...56,549,993
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G |
Hipk3 |
homeodomain interacting protein kinase 3 |
decreases expression |
EXP |
manganese chloride results in decreased expression of HIPK3 mRNA |
CTD |
PMID:28801915 |
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NCBI chr 3:94,349,778...94,419,185
Ensembl chr 3:94,352,969...94,419,048
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G |
Hist1h2an |
histone cluster 1, H2an |
decreases expression |
EXP |
manganese chloride results in decreased expression of HIST1H2AN mRNA |
CTD |
PMID:28801915 |
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NCBI chr17:43,779,174...43,779,775
Ensembl chr17:44,520,537...44,520,929 Ensembl chr17:44,520,537...44,520,929 Ensembl chr17:44,520,537...44,520,929 Ensembl chr17:44,520,537...44,520,929
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G |
Hist1h2bc |
histone cluster 1, H2bc |
decreases expression |
EXP |
manganese chloride results in decreased expression of HIST1H2BC mRNA |
CTD |
PMID:28801915 |
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NCBI chr17:44,736,184...44,738,393
Ensembl chr17:44,737,950...44,738,330 Ensembl chr17:44,737,950...44,738,330
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G |
Hist1h2bl |
histone cluster 1 H2B family member l |
decreases expression |
EXP |
manganese chloride results in decreased expression of HIST1H2BL mRNA |
CTD |
PMID:28801915 |
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NCBI chr17:44,748,445...44,748,910
Ensembl chr17:44,748,482...44,748,862
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G |
Hist1h2bq |
histone cluster 1 H2B family member Q |
decreases expression |
EXP |
manganese chloride results in decreased expression of HIST1H2BQ mRNA |
CTD |
PMID:28801915 |
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NCBI chr17:43,679,925...43,689,311
Ensembl chr17:43,679,925...43,689,311
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G |
Hist2h2aa2 |
histone cluster 2 H2A family member A2 |
decreases expression |
EXP |
manganese chloride results in decreased expression of HIST2H2AA2 mRNA |
CTD |
PMID:28801915 |
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NCBI chr 2:198,381,678...198,382,247
Ensembl chr 2:198,388,809...198,389,201 Ensembl chr 2:198,388,809...198,389,201
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G |
Hist3h2ba |
histone cluster 3, H2ba |
decreases expression |
EXP |
manganese chloride results in decreased expression of HIST3H2BA mRNA |
CTD |
PMID:28801915 |
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NCBI chr10:45,289,741...45,290,370
Ensembl chr10:45,289,741...45,290,370
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G |
Hmbox1 |
homeobox containing 1 |
decreases expression |
EXP |
manganese chloride results in decreased expression of HMBOX1 mRNA |
CTD |
PMID:28801915 |
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NCBI chr15:48,194,709...48,326,310
Ensembl chr15:48,199,995...48,284,548
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G |
Hmcn2 |
hemicentin 2 |
increases expression |
EXP |
manganese chloride results in increased expression of HMCN2 mRNA |
CTD |
PMID:28801915 |
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NCBI chr 3:10,384,873...10,536,529
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G |
Hmgb1 |
high mobility group box 1 |
increases expression multiple interactions |
ISO |
manganese chloride results in increased expression of HMGB1 mRNA corynoxine B affects the reaction [manganese chloride affects the reaction [HMGB1 protein binds to BECN1 protein]]; corynoxine B inhibits the reaction [manganese chloride promotes the reaction [HMGB1 protein binds to SNCA protein]]; manganese chloride affects the reaction [HMGB1 protein binds to BECN1 protein]; manganese chloride promotes the reaction [HMGB1 protein binds to SNCA protein]; manganese chloride results in increased expression of and affects the localization of HMGB1 protein |
CTD |
PMID:30578841 |
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NCBI chr12:7,082,529...7,090,246
Ensembl chr16:37,500,017...37,502,237
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G |
Hmgcs2 |
3-hydroxy-3-methylglutaryl-CoA synthase 2 |
decreases expression |
EXP |
manganese chloride results in decreased expression of HMGCS2 mRNA |
CTD |
PMID:26745496 |
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NCBI chr 2:200,452,623...200,480,785
Ensembl chr 2:200,452,624...200,479,423
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G |
Hmox1 |
heme oxygenase 1 |
affects response to substance increases expression multiple interactions |
ISO EXP |
HMOX1 protein affects the susceptibility to manganese chloride manganese chloride results in increased expression of HMOX1 protein manganese chloride results in increased expression of HMOX1 mRNA; manganese chloride results in increased expression of HMOX1 protein HMOX1 protein inhibits the reaction [manganese chloride results in increased abundance of Hydrogen Peroxide]; manganese chloride promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of HMOX1 mRNA]; manganese chloride promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of HMOX1 protein]; Melatonin inhibits the reaction [manganese chloride results in increased expression of HMOX1 protein] 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [manganese chloride results in increased expression of HMOX1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [manganese chloride results in increased expression of HMOX1 protein]; [Acetylcysteine affects the abundance of Reactive Oxygen Species] inhibits the reaction [manganese chloride promotes the reaction [NFE2L2 protein binds to HMOX1 promoter]]; [Acetylcysteine affects the abundance of Reactive Oxygen Species] inhibits the reaction [manganese chloride results in increased expression of HMOX1 protein]; [manganese chloride results in increased abundance of Manganese] which results in increased expression of HMOX1 protein; anacardic acid promotes the reaction [manganese chloride results in increased expression of HMOX1 mRNA]; GW 506033X promotes the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased expression of HMOX1 protein]; lactacystin promotes the reaction [manganese chloride promotes the reaction [NFE2L2 protein binds to HMOX1 promoter]]; lactacystin promotes the reaction [manganese chloride results in increased expression of HMOX1 protein]; manganese chloride promotes the reaction [[NFE2L2 protein binds to HMOX1 promoter] which results in increased expression of HMOX1 mRNA]; manganese chloride promotes the reaction [NFE2L2 protein binds to HMOX1 promoter]; SB 203580 inhibits the reaction [manganese chloride results in increased expression of HMOX1 protein]; tin protoporphyrin IX inhibits the reaction [manganese chloride results in increased expression of HMOX1 protein]; trichostatin A promotes the reaction [manganese chloride results in increased expression of HMOX1 mRNA]; trichostatin A promotes the reaction [manganese chloride results in increased expression of HMOX1 protein] |
CTD |
PMID:21107535 PMID:21384399 PMID:21963524 PMID:22281203 PMID:25288107 PMID:29054681 PMID:30040983 PMID:32574669 |
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NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
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G |
Hoxb9 |
homeo box B9 |
decreases expression |
ISO |
manganese chloride results in decreased expression of HOXB9 mRNA |
CTD |
PMID:17175027 |
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NCBI chr10:84,119,772...84,124,963
Ensembl chr10:84,119,884...84,123,390
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G |
Hoxd4 |
homeo box D4 |
increases expression |
EXP |
manganese chloride results in increased expression of HOXD4 mRNA |
CTD |
PMID:28801915 |
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NCBI chr 3:61,634,005...61,653,581
Ensembl chr 3:61,634,005...61,651,056
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G |
Hpx |
hemopexin |
decreases expression |
EXP |
manganese chloride results in decreased expression of HPX mRNA |
CTD |
PMID:28801915 |
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NCBI chr 1:170,423,558...170,431,066
Ensembl chr 1:170,423,483...170,431,073
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G |
Hrh1 |
histamine receptor H 1 |
decreases methylation |
ISO |
manganese chloride results in decreased methylation of HRH1 gene |
CTD |
PMID:27913844 |
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NCBI chr 4:146,374,596...146,458,148
Ensembl chr 4:146,455,332...146,457,074
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G |
Hrk |
harakiri, BCL2 interacting protein |
increases expression decreases methylation |
EXP |
manganese chloride results in increased expression of HRK mRNA manganese chloride results in decreased methylation of HRK gene |
CTD |
PMID:28801915 |
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NCBI chr12:44,008,879...44,029,211
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G |
Hsd11b1 |
hydroxysteroid 11-beta dehydrogenase 1 |
increases expression |
EXP |
manganese chloride results in increased expression of HSD11B1 mRNA |
CTD |
PMID:28801915 |
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NCBI chr13:111,946,626...111,996,536
Ensembl chr13:111,926,442...111,972,603
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G |
Hsp90b1 |
heat shock protein 90 beta family member 1 |
multiple interactions increases expression |
EXP |
SNCA protein promotes the reaction [manganese chloride results in increased expression of HSP90B1 mRNA]; SNCA protein promotes the reaction [manganese chloride results in increased expression of HSP90B1 protein] manganese chloride results in increased expression of HSP90B1 mRNA; manganese chloride results in increased expression of HSP90B1 protein |
CTD |
PMID:23934647 PMID:23948121 |
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NCBI chr 7:27,226,570...27,240,533
Ensembl chr 7:27,226,569...27,240,533
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G |
Hspa4l |
heat shock protein family A (Hsp70) member 4 like |
increases expression |
EXP |
manganese chloride results in increased expression of HSPA4L mRNA |
CTD |
PMID:28801915 |
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NCBI chr 2:127,625,737...127,682,864
Ensembl chr 2:127,625,683...127,677,503
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G |
Hspa5 |
heat shock protein family A (Hsp70) member 5 |
multiple interactions increases expression |
EXP |
[manganese chloride results in increased abundance of Manganese] which results in increased expression of HSPA5 mRNA; SNCA protein promotes the reaction [manganese chloride results in increased expression of HSPA5 mRNA]; SNCA protein promotes the reaction [manganese chloride results in increased expression of HSPA5 protein] manganese chloride results in increased expression of HSPA5 mRNA; manganese chloride results in increased expression of HSPA5 protein |
CTD |
PMID:23934647 PMID:23948121 PMID:25732873 PMID:32574669 |
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NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
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G |
Hspb8 |
heat shock protein family B (small) member 8 |
decreases expression |
EXP |
manganese chloride results in decreased expression of HSPB8 mRNA |
CTD |
PMID:28801915 |
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NCBI chr12:45,905,371...45,920,014
Ensembl chr12:45,905,371...45,920,013
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G |
Htra1 |
HtrA serine peptidase 1 |
increases expression |
EXP |
manganese chloride results in increased expression of HTRA1 mRNA |
CTD |
PMID:28801915 |
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NCBI chr 1:201,499,067...201,548,508
Ensembl chr 1:201,499,028...201,548,513
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G |
Htt |
huntingtin |
affects response to substance |
ISO |
HTT affects the susceptibility to manganese chloride |
CTD |
PMID:22363539 |
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NCBI chr14:81,105,139...81,254,637
Ensembl chr14:81,105,139...81,254,637
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G |
Icam1 |
intercellular adhesion molecule 1 |
multiple interactions decreases expression |
ISO EXP |
manganese chloride inhibits the reaction [CCL2 protein results in increased expression of ICAM1 protein]; manganese chloride inhibits the reaction [Glucose results in increased expression of ICAM1 protein] manganese chloride results in decreased expression of ICAM1 protein |
CTD |
PMID:23329836 |
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NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
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G |
Id1 |
inhibitor of DNA binding 1, HLH protein |
increases expression |
ISO |
manganese chloride results in increased expression of ID1 mRNA |
CTD |
PMID:17467022 |
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NCBI chr 3:148,214,623...148,216,715
Ensembl chr 3:148,215,540...148,216,718
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G |
Id2 |
inhibitor of DNA binding 2 |
increases expression decreases expression |
ISO EXP |
manganese chloride results in increased expression of ID2 mRNA manganese chloride results in decreased expression of ID2 mRNA |
CTD |
PMID:17175027 PMID:28801915 |
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NCBI chr 6:44,360,077...44,361,908
Ensembl chr 6:44,348,501...44,363,915
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G |
Ifng |
interferon gamma |
increases expression multiple interactions |
EXP ISO |
manganese chloride results in increased expression of IFNG protein manganese chloride promotes the reaction [[TNF protein co-treated with IFNG protein] promotes the reaction [NOS2 protein results in increased chemical synthesis of Nitric Oxide]]; manganese chloride promotes the reaction [TNF protein co-treated with and results in increased chemical synthesis of IFNG protein co-treated with and results in increased chemical synthesis of Nitric Oxide]; manganese chloride promotes the reaction [TNF protein co-treated with and results in increased expression of IFNG protein co-treated with and results in increased expression of NOS2 mRNA]; manganese chloride promotes the reaction [TNF protein co-treated with and results in increased expression of IFNG protein co-treated with and results in increased expression of NOS2 protein]; NFKBIA protein affects the reaction [manganese chloride promotes the reaction [TNF protein co-treated with and results in increased chemical synthesis of IFNG protein co-treated with and results in increased chemical synthesis of Nitric Oxide]]; NFKBIA protein affects the reaction [manganese chloride promotes the reaction [TNF protein co-treated with and results in increased expression of IFNG protein co-treated with and results in increased expression of NOS2 mRNA]]; NFKBIA protein affects the reaction [manganese chloride promotes the reaction [TNF protein co-treated with and results in increased expression of IFNG protein co-treated with and results in increased expression of NOS2 protein]] |
CTD |
PMID:16168523 PMID:20798247 |
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NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
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G |
Igf1 |
insulin-like growth factor 1 |
increases expression |
EXP |
manganese chloride results in increased expression of IGF1 mRNA |
CTD |
PMID:21402727 |
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NCBI chr 7:28,412,123...28,491,815
Ensembl chr 7:28,412,198...28,486,609
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G |
Igf1r |
insulin-like growth factor 1 receptor |
increases expression decreases expression |
EXP |
manganese chloride results in increased expression of IGF1R protein manganese chloride results in decreased expression of IGF1R mRNA |
CTD |
PMID:19276553 PMID:21402727 |
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NCBI chr 1:128,924,921...129,213,816
Ensembl chr 1:128,924,966...129,206,516
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G |
Igf2 |
insulin-like growth factor 2 |
decreases methylation |
ISO |
manganese chloride results in decreased methylation of IGF2 gene |
CTD |
PMID:27913844 |
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NCBI chr 1:215,828,102...215,839,081
Ensembl chr 1:215,828,102...215,846,911
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G |
Igf2r |
insulin-like growth factor 2 receptor |
decreases expression |
EXP |
manganese chloride results in decreased expression of IGF2R mRNA |
CTD |
PMID:19276553 |
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NCBI chr 1:48,176,095...48,264,482
Ensembl chr 1:48,176,106...48,264,477
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G |
Igfbp5 |
insulin-like growth factor binding protein 5 |
increases expression |
EXP |
manganese chloride results in increased expression of IGFBP5 mRNA |
CTD |
PMID:28801915 |
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NCBI chr 9:80,154,230...80,166,813
Ensembl chr 9:80,150,211...80,167,033
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G |
Ikbkb |
inhibitor of nuclear factor kappa B kinase subunit beta |
multiple interactions |
ISO |
IKBKB gene mutant form results in increased susceptibility to [manganese chloride results in increased abundance of Manganese] |
CTD |
PMID:32692843 |
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NCBI chr16:74,177,233...74,230,809
Ensembl chr16:74,177,215...74,230,815
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G |
Il12a |
interleukin 12A |
increases expression multiple interactions |
ISO |
manganese chloride results in increased expression of IL12A mRNA manganese chloride promotes the reaction [SNCA protein results in increased expression of [IL12A protein binds to IL12B protein]] manganese chloride results in increased expression of [IL12A protein binds to IL12B protein] |
CTD |
PMID:17175027 PMID:28539244 |
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NCBI chr 2:165,076,945...165,083,996
Ensembl chr 2:165,076,607...165,084,318
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G |
Il12b |
interleukin 12B |
multiple interactions increases expression |
ISO |
manganese chloride promotes the reaction [SNCA protein results in increased expression of [IL12A protein binds to IL12B protein]] manganese chloride results in increased expression of IL12B mRNA manganese chloride results in increased expression of [IL12A protein binds to IL12B protein] |
CTD |
PMID:28539244 |
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NCBI chr10:30,034,447...30,048,774
Ensembl chr10:30,038,709...30,048,085
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G |
Il18 |
interleukin 18 |
multiple interactions increases expression |
ISO |
acetovanillone analog inhibits the reaction [manganese chloride results in increased expression of IL18 mRNA] |
CTD |
PMID:28539244 |
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NCBI chr 8:55,009,666...55,016,286
Ensembl chr 8:54,993,859...55,016,299
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G |
Il1a |
interleukin 1 alpha |
increases expression |
EXP |
manganese chloride results in increased expression of IL1A mRNA |
CTD |
PMID:25219578 |
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NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086
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G |
Il1b |
interleukin 1 beta |
increases expression multiple interactions decreases expression |
EXP ISO |
manganese chloride results in increased expression of IL1B protein [manganese chloride co-treated with SNCA protein] results in increased expression of IL1B mRNA; [manganese chloride co-treated with SNCA protein] results in increased expression of IL1B protein manganese chloride results in increased expression of IL1B mRNA manganese chloride results in decreased expression of IL1B mRNA [Lipopolysaccharides co-treated with manganese chloride] results in increased expression of IL1B protein; acetovanillone analog inhibits the reaction [manganese chloride results in increased expression of IL1B mRNA] [manganese chloride results in increased abundance of Manganese] which results in increased expression of IL1B protein; Ethanol promotes the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased expression of IL1B protein]; Minocycline inhibits the reaction [manganese chloride results in increased expression of IL1B protein] |
CTD |
PMID:15601679 PMID:18836210 PMID:27427241 PMID:28539244 PMID:33314588 |
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NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
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G |
Il1r1 |
interleukin 1 receptor type 1 |
increases expression |
EXP |
manganese chloride results in increased expression of IL1R1 mRNA |
CTD |
PMID:28801915 |
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NCBI chr 9:46,962,291...47,038,139
Ensembl chr 9:46,962,288...47,036,670
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G |
Il1r2 |
interleukin 1 receptor type 2 |
increases expression |
EXP |
manganese chloride results in increased expression of IL1R2 mRNA |
CTD |
PMID:28801915 |
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NCBI chr 9:46,840,646...46,881,241
Ensembl chr 9:46,840,992...46,881,264
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G |
Il1rl1 |
interleukin 1 receptor-like 1 |
decreases expression increases expression |
EXP |
manganese chloride results in decreased expression of IL1RL1 mRNA manganese chloride results in increased expression of IL1RL1 mRNA |
CTD |
PMID:26745496 PMID:28801915 |
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NCBI chr 9:47,133,483...47,184,316
Ensembl chr 9:47,134,034...47,182,170
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G |
Il1rn |
interleukin 1 receptor antagonist |
increases expression |
EXP |
manganese chloride results in increased expression of IL1RN mRNA |
CTD |
PMID:28801915 |
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NCBI chr 3:1,449,778...1,468,624
Ensembl chr 3:1,452,644...1,468,614
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G |
Il23a |
interleukin 23 subunit alpha |
increases expression |
EXP |
manganese chloride results in increased expression of IL23A mRNA |
CTD |
PMID:28801915 |
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NCBI chr 7:2,710,609...2,712,723
Ensembl chr 7:2,710,609...2,712,723
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G |
Il36rn |
interleukin 36 receptor antagonist |
increases expression |
EXP |
manganese chloride results in increased expression of IL36RN mRNA |
CTD |
PMID:28801915 |
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NCBI chr 3:1,385,256...1,392,275
Ensembl chr 3:1,385,654...1,392,275
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G |
Il6 |
interleukin 6 |
multiple interactions increases expression increases secretion decreases expression |
ISO EXP |
6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [manganese chloride promotes the reaction [Lipopolysaccharides results in increased expression of IL6 protein]]; Buthionine Sulfoximine inhibits the reaction [manganese chloride promotes the reaction [Lipopolysaccharides results in increased expression of IL6 protein]]; Lipopolysaccharides promotes the reaction [manganese chloride results in increased expression of IL6 protein]; manganese chloride promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL6 mRNA]; manganese chloride promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL6 protein]; manganese chloride promotes the reaction [Lipopolysaccharides results in increased expression of IL6 protein]; tin protoporphyrin IX inhibits the reaction [manganese chloride promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL6 mRNA]]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [manganese chloride promotes the reaction [Lipopolysaccharides results in increased expression of IL6 protein]]; zinc protoporphyrin inhibits the reaction [manganese chloride promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL6 protein]] manganese chloride results in increased expression of IL6 mRNA manganese chloride promotes the reaction [SNCA protein results in increased expression of IL6 mRNA] manganese chloride results in increased secretion of IL6 protein manganese chloride results in decreased expression of IL6 mRNA manganese chloride results in increased expression of IL6 mRNA; manganese chloride results in increased expression of IL6 protein |
CTD |
PMID:15601679 PMID:17065364 PMID:19815061 PMID:21963524 PMID:25219578 PMID:27427241 PMID:28539244 |
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NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
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G |
Il7 |
interleukin 7 |
increases expression |
ISO |
manganese chloride results in increased expression of IL7 mRNA |
CTD |
PMID:17175027 |
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NCBI chr 2:96,427,884...96,474,979
Ensembl chr 2:96,439,286...96,474,977
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G |
Ins2 |
insulin 2 |
multiple interactions |
ISO |
[manganese chloride results in increased abundance of Manganese] inhibits the reaction [Glucose results in increased secretion of INS protein] |
CTD |
PMID:31555879 |
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NCBI chr 1:215,856,967...215,858,034
Ensembl chr 1:215,856,971...215,858,034
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G |
Insig1 |
insulin induced gene 1 |
decreases expression increases methylation |
EXP |
manganese chloride results in decreased expression of INSIG1 mRNA manganese chloride results in increased methylation of INSIG1 gene |
CTD |
PMID:28801915 |
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NCBI chr 4:342,302...350,515
Ensembl chr 4:342,302...350,515
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G |
Insr |
insulin receptor |
decreases expression increases expression increases phosphorylation |
EXP |
manganese chloride results in decreased expression of INSR mRNA manganese chloride results in increased expression of INSR mRNA manganese chloride results in increased phosphorylation of INSR protein |
CTD |
PMID:2475105 PMID:19276553 PMID:28801915 |
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NCBI chr12:1,682,527...1,816,414
Ensembl chr12:1,680,957...1,816,414
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G |
Ints2 |
integrator complex subunit 2 |
decreases expression |
EXP |
manganese chloride results in decreased expression of INTS2 mRNA |
CTD |
PMID:28801915 |
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NCBI chr10:73,632,805...73,690,952
Ensembl chr10:73,634,255...73,690,887
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G |
Iqcg |
IQ motif containing G |
increases expression |
EXP |
manganese chloride results in increased expression of IQCG mRNA |
CTD |
PMID:28801915 |
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NCBI chr11:70,967,228...71,007,708
Ensembl chr11:70,967,223...71,105,403
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G |
Iqgap1 |
IQ motif containing GTPase activating protein 1 |
increases expression |
EXP |
manganese chloride results in increased expression of IQGAP1 mRNA |
CTD |
PMID:28801915 |
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NCBI chr 1:142,525,041...142,615,673
Ensembl chr 1:142,525,046...142,615,673
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G |
Ireb2 |
iron responsive element binding protein 2 |
decreases activity increases activity |
EXP |
manganese chloride results in decreased activity of IREB2 protein manganese chloride results in increased activity of IREB2 protein |
CTD |
PMID:15893546 PMID:16568477 |
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NCBI chr 8:59,450,974...59,503,634
Ensembl chr 8:59,420,123...59,501,118
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G |
Irf2 |
interferon regulatory factor 2 |
decreases expression |
EXP |
manganese chloride results in decreased expression of IRF2 mRNA |
CTD |
PMID:28801915 |
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NCBI chr16:48,582,354...48,732,129
Ensembl chr16:48,582,026...48,732,932
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G |
Ism1 |
isthmin 1 |
increases expression |
EXP |
manganese chloride results in increased expression of ISM1 mRNA |
CTD |
PMID:28801915 |
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NCBI chr 3:132,736,433...132,808,544
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G |
Itga10 |
integrin subunit alpha 10 |
increases expression |
EXP |
manganese chloride results in increased expression of ITGA10 mRNA |
CTD |
PMID:28801915 |
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NCBI chr 2:198,772,937...198,792,253
Ensembl chr 2:198,772,937...198,792,253
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G |
Itga2b |
integrin subunit alpha 2b |
multiple interactions |
ISO |
manganese chloride inhibits the reaction [TLN1 protein mutant form results in decreased activity of [ITGB3 protein binds to ITGA2B protein]]; manganese chloride results in increased activity of [ITGB3 protein binds to ITGA2B protein] |
CTD |
PMID:20971947 |
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NCBI chr10:90,397,960...90,416,550
Ensembl chr10:90,398,132...90,415,070
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G |
Itga3 |
integrin subunit alpha 3 |
increases expression |
ISO |
manganese chloride results in increased expression of ITGA3 mRNA |
CTD |
PMID:17175027 |
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NCBI chr10:82,855,841...82,887,755
Ensembl chr10:82,855,613...82,887,497
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G |
Itga8 |
integrin subunit alpha 8 |
increases expression increases methylation |
EXP |
manganese chloride results in increased expression of ITGA8 mRNA manganese chloride results in increased methylation of ITGA8 gene |
CTD |
PMID:28801915 |
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NCBI chr17:79,321,893...79,676,927
Ensembl chr17:79,321,900...79,676,499
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G |
Itgam |
integrin subunit alpha M |
increases expression |
EXP |
manganese chloride results in increased expression of ITGAM protein |
CTD |
PMID:12106697 |
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NCBI chr 1:199,495,312...199,545,738
Ensembl chr 1:199,495,298...199,623,960
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G |
Itgav |
integrin subunit alpha V |
multiple interactions |
ISO |
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [manganese chloride affects the localization of and affects the activity of [ITGB3 protein binds to ITGAV protein]]; [AG 1879 results in decreased activity of SRC protein] promotes the reaction [manganese chloride affects the localization of and affects the activity of [ITGB3 protein binds to ITGAV protein]]; [CGP 77675 results in decreased activity of SRC protein] promotes the reaction [manganese chloride affects the localization of and affects the activity of [ITGB3 protein binds to ITGAV protein]]; arginyl-glycyl-aspartic acid inhibits the reaction [manganese chloride affects the localization of and affects the activity of [ITGB3 protein binds to ITGAV protein]]; manganese chloride affects the localization of and affects the activity of [ITGB3 protein binds to ITGAV protein]; wortmannin inhibits the reaction [manganese chloride affects the localization of and affects the activity of [ITGB3 protein binds to ITGAV protein]] |
CTD |
PMID:15213856 |
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NCBI chr 3:71,113,269...71,205,958
Ensembl chr 3:71,114,100...71,202,411
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G |
Itgb3 |
integrin subunit beta 3 |
multiple interactions |
ISO |
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [manganese chloride affects the localization of and affects the activity of [ITGB3 protein binds to ITGAV protein]]; [AG 1879 results in decreased activity of SRC protein] promotes the reaction [manganese chloride affects the localization of and affects the activity of [ITGB3 protein binds to ITGAV protein]]; [CGP 77675 results in decreased activity of SRC protein] promotes the reaction [manganese chloride affects the localization of and affects the activity of [ITGB3 protein binds to ITGAV protein]]; arginyl-glycyl-aspartic acid inhibits the reaction [manganese chloride affects the localization of and affects the activity of [ITGB3 protein binds to ITGAV protein]]; manganese chloride affects the localization of and affects the activity of [ITGB3 protein binds to ITGAV protein]; Wortmannin inhibits the reaction [manganese chloride affects the localization of and affects the activity of [ITGB3 protein binds to ITGAV protein]] manganese chloride inhibits the reaction [TLN1 protein mutant form results in decreased activity of [ITGB3 protein binds to ITGA2B protein]]; manganese chloride results in increased activity of [ITGB3 protein binds to ITGA2B protein] |
CTD |
PMID:15213856 PMID:20971947 |
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NCBI chr10:92,667,869...92,783,413
Ensembl chr10:92,667,869...92,783,410
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G |
Itgb5 |
integrin subunit beta 5 |
increases expression |
ISO |
manganese chloride results in increased expression of ITGB5 mRNA |
CTD |
PMID:17175027 |
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NCBI chr11:70,056,500...70,172,164
Ensembl chr11:70,056,500...70,172,372
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G |
Itgb6 |
integrin subunit beta 6 |
decreases methylation increases expression increases methylation |
ISO EXP |
manganese chloride results in decreased methylation of ITGB6 gene manganese chloride results in increased expression of ITGB6 mRNA manganese chloride results in increased methylation of ITGB6 gene |
CTD |
PMID:27913844 PMID:28801915 |
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NCBI chr 3:46,652,624...46,775,362
Ensembl chr 3:46,652,623...46,726,958
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G |
Itih1 |
inter-alpha trypsin inhibitor, heavy chain 1 |
multiple interactions |
ISO |
manganese chloride promotes the reaction [ITIH1 protein binds to TNFAIP6 protein] |
CTD |
PMID:16768462 |
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NCBI chr16:7,012,376...7,026,542
Ensembl chr16:7,012,354...7,026,540
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G |
Itih2 |
inter-alpha-trypsin inhibitor heavy chain 2 |
multiple interactions |
ISO |
manganese chloride promotes the reaction [ITIH2 protein binds to TNFAIP6 protein] |
CTD |
PMID:16768462 |
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NCBI chr17:72,160,734...72,197,248
Ensembl chr17:72,160,735...72,195,509
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G |
Jun |
Jun proto-oncogene, AP-1 transcription factor subunit |
multiple interactions increases phosphorylation |
EXP |
manganese chloride results in increased expression of and results in increased phosphorylation of JUN protein; pyrazolanthrone inhibits the reaction [manganese chloride results in increased phosphorylation of JUN protein] |
CTD |
PMID:9751194 PMID:15342272 |
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NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
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G |
Kcng1 |
potassium voltage-gated channel modifier subfamily G member 1 |
increases expression |
EXP |
manganese chloride results in increased expression of KCNG1 mRNA |
CTD |
PMID:28801915 |
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NCBI chr 3:165,020,230...165,040,966
Ensembl chr 3:165,020,230...165,039,707
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G |
Kcnh4 |
potassium voltage-gated channel subfamily H member 4 |
decreases expression |
EXP |
manganese chloride results in decreased expression of KCNH4 mRNA |
CTD |
PMID:28801915 |
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NCBI chr10:88,645,341...88,667,447
Ensembl chr10:88,647,575...88,667,345
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G |
Kcnh6 |
potassium voltage-gated channel subfamily H member 6 |
increases expression |
EXP |
manganese chloride results in increased expression of KCNH6 mRNA |
CTD |
PMID:28801915 |
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NCBI chr10:94,207,336...94,228,236
Ensembl chr10:94,207,314...94,228,236
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G |
Kcnip3 |
potassium voltage-gated channel interacting protein 3 |
increases expression |
ISO |
manganese chloride results in increased expression of KCNIP3 mRNA |
CTD |
PMID:17175027 |
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NCBI chr 3:120,023,062...120,087,650
Ensembl chr 3:120,023,917...120,087,136
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G |
Kcnj11 |
potassium inwardly-rectifying channel, subfamily J, member 11 |
multiple interactions |
ISO |
[manganese chloride results in increased abundance of Manganese] which results in decreased expression of KCNJ11 protein |
CTD |
PMID:32659473 |
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NCBI chr 1:102,103,093...102,107,134
Ensembl chr 1:102,103,094...102,106,127
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G |
Kcnj3 |
potassium inwardly-rectifying channel, subfamily J, member 3 |
increases expression |
ISO |
manganese chloride results in increased expression of KCNJ3 mRNA |
CTD |
PMID:17175027 |
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NCBI chr 3:41,019,898...41,181,070
Ensembl chr 3:41,019,898...41,181,070
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G |
Kcnj8 |
potassium inwardly-rectifying channel, subfamily J, member 8 |
multiple interactions |
ISO |
[manganese chloride results in increased abundance of Manganese] which results in decreased expression of KCNJ8 protein |
CTD |
PMID:32659473 |
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NCBI chr 4:176,783,287...176,789,143
Ensembl chr 4:176,782,498...176,789,304
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G |
Kcnk12 |
potassium two pore domain channel subfamily K member 12 |
decreases expression |
EXP |
manganese chloride results in decreased expression of KCNK12 mRNA |
CTD |
PMID:28801915 |
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NCBI chr 6:11,373,917...11,494,459
Ensembl chr 6:11,373,917...11,494,459
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G |
Kcnq1 |
potassium voltage-gated channel subfamily Q member 1 |
increases expression |
EXP |
manganese chloride results in increased expression of KCNQ1 mRNA |
CTD |
PMID:28801915 |
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NCBI chr 1:216,293,087...216,630,339
Ensembl chr 1:216,293,087...216,630,339
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G |
Kcnq2 |
potassium voltage-gated channel subfamily Q member 2 |
increases expression |
EXP |
manganese chloride results in increased expression of KCNQ2 mRNA |
CTD |
PMID:28801915 |
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NCBI chr 3:176,585,897...176,645,029
Ensembl chr 3:176,589,906...176,644,951
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G |
Keap1 |
Kelch-like ECH-associated protein 1 |
affects expression multiple interactions |
ISO |
manganese chloride affects the expression of KEAP1 protein Melatonin affects the reaction [manganese chloride affects the expression of KEAP1 protein] |
CTD |
PMID:25288107 |
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NCBI chr 8:22,250,518...22,259,868
Ensembl chr 8:22,250,518...22,259,779
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G |
Kera |
keratocan |
increases expression |
EXP |
manganese chloride results in increased expression of KERA mRNA |
CTD |
PMID:26745496 |
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NCBI chr 7:38,858,062...38,865,515
Ensembl chr 7:38,858,062...38,865,515
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G |
Kif3b |
kinesin family member 3B |
increases expression |
EXP |
manganese chloride results in increased expression of KIF3B mRNA |
CTD |
PMID:28801915 |
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NCBI chr 3:148,772,937...148,813,342
Ensembl chr 3:148,773,259...148,813,293
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G |
Kif5c |
kinesin family member 5C |
increases expression |
EXP |
manganese chloride results in increased expression of KIF5C mRNA |
CTD |
PMID:28801915 |
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NCBI chr 3:35,014,157...35,257,417
Ensembl chr 3:35,014,538...35,257,407
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G |
Kiss1r |
KISS1 receptor |
increases expression |
EXP |
manganese chloride results in increased expression of KISS1R mRNA |
CTD |
PMID:28801915 |
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NCBI chr 7:12,606,210...12,609,868
Ensembl chr 7:12,606,210...12,609,868
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G |
Klf2 |
Kruppel-like factor 2 |
increases expression |
EXP |
manganese chloride results in increased expression of KLF2 mRNA |
CTD |
PMID:28801915 |
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NCBI chr16:19,223,087...19,225,037
Ensembl chr16:19,223,087...19,225,037
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G |
Klf4 |
Kruppel like factor 4 |
increases expression |
ISO |
manganese chloride results in increased expression of KLF4 mRNA |
CTD |
PMID:17175027 |
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NCBI chr 5:72,283,311...72,287,669
Ensembl chr 5:72,283,313...72,287,669
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G |
Klf5 |
Kruppel-like factor 5 |
decreases expression decreases methylation increases expression |
ISO EXP |
manganese chloride results in decreased expression of KLF5 mRNA manganese chloride results in decreased methylation of KLF5 gene manganese chloride results in increased expression of KLF5 mRNA |
CTD |
PMID:17467022 PMID:28801915 |
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NCBI chr15:83,703,796...83,722,921
Ensembl chr15:83,703,791...83,722,921
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G |
Klf9 |
Kruppel-like factor 9 |
decreases expression |
ISO |
manganese chloride results in decreased expression of KLF9 mRNA |
CTD |
PMID:17175027 |
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NCBI chr 1:240,908,483...240,933,198
Ensembl chr 1:240,908,483...240,933,198
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G |
Klhdc8a |
kelch domain containing 8A |
increases expression |
EXP |
manganese chloride results in increased expression of KLHDC8A mRNA |
CTD |
PMID:28801915 |
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NCBI chr13:49,074,644...49,082,729
Ensembl chr13:49,074,644...49,082,729
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G |
Kng2 |
kininogen 2 |
decreases expression |
EXP |
manganese chloride results in decreased expression of KNG1 mRNA |
CTD |
PMID:28801915 |
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NCBI chr11:81,509,185...81,516,759
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G |
Krt7 |
keratin 7 |
increases expression |
EXP |
manganese chloride results in increased expression of KRT7 mRNA |
CTD |
PMID:28801915 |
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NCBI chr 7:143,059,731...143,075,907
Ensembl chr 7:143,059,764...143,075,907
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G |
Krt76 |
keratin 76 |
increases expression |
EXP |
manganese chloride results in increased expression of KRT76 mRNA |
CTD |
PMID:28801915 |
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NCBI chr 7:143,488,668...143,497,108
Ensembl chr 7:143,488,684...143,497,108
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G |
Krt79 |
keratin 79 |
decreases expression |
EXP |
manganese chloride results in decreased expression of KRT79 mRNA |
CTD |
PMID:28801915 |
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NCBI chr 7:143,528,204...143,538,713
Ensembl chr 7:143,528,204...143,538,579
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G |
Krt81 |
keratin 81 |
increases expression |
EXP |
manganese chloride results in increased expression of KRT81 mRNA |
CTD |
PMID:28801915 |
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NCBI chr 7:143,107,901...143,113,006
Ensembl chr 7:143,107,901...143,112,960
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G |
Krt83 |
keratin 83 |
increases expression |
EXP |
manganese chloride results in increased expression of KRT83 mRNA |
CTD |
PMID:28801915 |
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NCBI chr 7:143,078,996...143,085,833
Ensembl chr 7:143,078,996...143,085,833
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G |
Krtap1-3 |
keratin associated protein 1-3 |
increases expression |
EXP |
manganese chloride results in increased expression of KRTAP1-3 mRNA |
CTD |
PMID:28801915 |
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NCBI chr10:87,509,822...87,510,645
Ensembl chr10:87,510,101...87,510,629
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G |
Lacc1 |
laccase domain containing 1 |
increases expression |
EXP |
manganese chloride results in increased expression of LACC1 mRNA |
CTD |
PMID:28801915 |
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NCBI chr15:59,199,537...59,217,200
Ensembl chr15:59,209,829...59,215,803
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G |
Lcat |
lecithin cholesterol acyltransferase |
increases expression |
EXP |
manganese chloride results in increased expression of LCAT mRNA |
CTD |
PMID:28801915 |
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NCBI chr19:37,913,333...37,916,799
Ensembl chr19:37,913,336...37,916,813
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G |
Lck |
LCK proto-oncogene, Src family tyrosine kinase |
multiple interactions |
ISO |
[manganese chloride co-treated with LCK protein] results in increased phosphorylation of CD28 protein; Tetradecanoylphorbol Acetate inhibits the reaction [[manganese chloride co-treated with LCK protein] results in increased phosphorylation of CD28 protein] |
CTD |
PMID:8662792 |
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NCBI chr 5:147,750,976...147,779,627
Ensembl chr 5:147,750,973...147,761,983
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G |
Ldlrad4 |
low density lipoprotein receptor class A domain containing 4 |
increases expression |
EXP |
manganese chloride results in increased expression of LDLRAD4 mRNA |
CTD |
PMID:28801915 |
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NCBI chr18:63,717,423...64,045,224
Ensembl chr18:63,882,610...64,044,023
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G |
Lgals3 |
galectin 3 |
increases expression |
EXP |
manganese chloride results in increased expression of LGALS3 mRNA |
CTD |
PMID:28801915 |
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NCBI chr15:24,153,602...24,165,537
Ensembl chr15:24,141,651...24,165,537
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G |
Lgi4 |
leucine-rich repeat LGI family, member 4 |
increases expression |
EXP |
manganese chloride results in increased expression of LGI4 mRNA |
CTD |
PMID:28801915 |
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NCBI chr 1:89,491,588...89,502,939
Ensembl chr 1:89,491,654...89,502,974
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G |
Lgr4 |
leucine-rich repeat-containing G protein-coupled receptor 4 |
decreases expression |
EXP |
manganese chloride results in decreased expression of LGR4 mRNA |
CTD |
PMID:28801915 |
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NCBI chr 3:101,051,960...101,152,119
Ensembl chr 3:101,051,955...101,152,119
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G |
Lhb |
luteinizing hormone subunit beta |
multiple interactions decreases expression |
EXP |
Quercetin inhibits the reaction [manganese chloride results in decreased expression of LHB protein] |
CTD |
PMID:28040552 |
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NCBI chr 1:101,409,992...101,413,725
Ensembl chr 1:101,410,019...101,413,724
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G |
Lhfpl2 |
LHFPL tetraspan subfamily member 2 |
increases expression |
EXP |
manganese chloride results in increased expression of LHFPL2 mRNA |
CTD |
PMID:28801915 |
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NCBI chr 2:23,705,491...23,852,021
Ensembl chr 2:23,770,721...23,852,021
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G |
Lhx1 |
LIM homeobox 1 |
decreases expression |
EXP |
manganese chloride results in decreased expression of LHX1 mRNA |
CTD |
PMID:28801915 |
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NCBI chr10:71,843,991...71,849,293
Ensembl chr10:71,843,991...71,849,293
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G |
Lif |
LIF, interleukin 6 family cytokine |
increases expression |
EXP |
manganese chloride results in increased expression of LIF mRNA |
CTD |
PMID:28801915 |
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NCBI chr14:84,482,652...84,500,574
Ensembl chr14:84,482,674...84,500,642
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G |
Lman2 |
lectin, mannose-binding 2 |
increases expression |
ISO |
manganese chloride results in increased expression of LMAN2 mRNA |
CTD |
PMID:17175027 |
|
NCBI chr17:9,798,136...9,815,820
Ensembl chr17:9,797,907...9,816,139
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G |
Lmod2 |
leiomodin 2 |
decreases expression |
EXP |
manganese chloride results in decreased expression of LMOD2 mRNA |
CTD |
PMID:28801915 |
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NCBI chr 4:51,553,439...51,561,135
Ensembl chr 4:51,553,454...51,561,174
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G |
LOC102555183 |
zinc finger protein OZF-like |
increases expression |
EXP |
manganese chloride results in increased expression of ZFP146 mRNA |
CTD |
PMID:28801915 |
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NCBI chr10:74,767,535...74,770,723
Ensembl chr10:74,768,759...74,769,637
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G |
Lox |
lysyl oxidase |
decreases expression |
EXP |
manganese chloride results in decreased expression of LOX mRNA |
CTD |
PMID:28801915 |
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NCBI chr18:47,500,320...47,577,819
Ensembl chr18:47,500,330...47,577,819
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G |
Lpal2 |
lipoprotein(a) like 2, pseudogene |
decreases expression |
EXP |
manganese chloride results in decreased expression of LPAL2 mRNA |
CTD |
PMID:28801915 |
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NCBI chr 4:165,682,977...165,737,759
Ensembl chr 4:165,732,643...165,737,755
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G |
Lpar1 |
lysophosphatidic acid receptor 1 |
decreases expression |
EXP |
manganese chloride results in decreased expression of LPAR1 mRNA |
CTD |
PMID:28801915 |
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NCBI chr 5:75,557,038...75,678,067
Ensembl chr 5:75,557,042...75,676,584
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G |
Lpcat4 |
lysophosphatidylcholine acyltransferase 4 |
decreases expression |
EXP |
manganese chloride results in decreased expression of LPCAT4 mRNA |
CTD |
PMID:28801915 |
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NCBI chr 3:103,725,762...103,733,888
Ensembl chr 3:103,726,238...103,733,354
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G |
Lpin1 |
lipin 1 |
decreases expression |
EXP |
manganese chloride results in decreased expression of LPIN1 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr 6:41,796,214...41,905,149
Ensembl chr 6:41,799,749...41,870,046
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G |
Lrat |
lecithin retinol acyltransferase |
increases expression |
EXP |
manganese chloride results in increased expression of LRAT mRNA |
CTD |
PMID:26745496 |
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NCBI chr 2:181,896,304...181,905,366
Ensembl chr 2:181,896,305...181,905,300
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G |
Lrp2 |
LDL receptor related protein 2 |
decreases expression |
EXP |
manganese chloride results in decreased expression of LRP2 mRNA |
CTD |
PMID:28801915 |
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NCBI chr 3:55,665,153...55,822,484
Ensembl chr 3:55,665,145...55,822,551
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G |
Lrp8 |
LDL receptor related protein 8 |
increases expression |
ISO |
manganese chloride results in increased expression of LRP8 mRNA |
CTD |
PMID:22407947 |
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NCBI chr 5:127,404,348...127,476,636
Ensembl chr 5:127,404,450...127,476,641
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G |
Lrrc10b |
leucine rich repeat containing 10B |
increases methylation |
EXP |
manganese chloride results in increased methylation of LRRC10B gene |
CTD |
PMID:28801915 |
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NCBI chr 1:226,500,692...226,501,920
Ensembl chr 1:226,500,692...226,501,920
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G |
Lrrc15 |
leucine rich repeat containing 15 |
increases expression |
EXP |
manganese chloride results in increased expression of LRRC15 mRNA |
CTD |
PMID:28801915 |
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NCBI chr11:74,040,846...74,052,179
Ensembl chr11:74,050,166...74,051,902
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G |
Lrrc8b |
leucine rich repeat containing 8 VRAC subunit B |
increases expression |
EXP |
manganese chloride results in increased expression of LRRC8B mRNA |
CTD |
PMID:28801915 |
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NCBI chr14:5,414,872...5,482,004
Ensembl chr14:5,418,741...5,428,757
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G |
Lrrk1 |
leucine-rich repeat kinase 1 |
increases expression |
EXP |
manganese chloride results in increased expression of LRRK1 mRNA |
CTD |
PMID:28801915 |
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NCBI chr 1:127,166,866...127,301,053
Ensembl chr 1:127,166,431...127,292,090
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G |
Ly6g5b |
lymphocyte antigen 6 family member G5B |
increases expression |
EXP |
manganese chloride results in increased expression of LY6G5B mRNA |
CTD |
PMID:28801915 |
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NCBI chr20:5,106,248...5,108,604
Ensembl chr20:5,106,890...5,107,899
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G |
Lyn |
LYN proto-oncogene, Src family tyrosine kinase |
decreases methylation |
ISO |
manganese chloride results in decreased methylation of LYN gene |
CTD |
PMID:27913844 |
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NCBI chr 5:16,526,058...16,642,648
Ensembl chr 5:16,526,058...16,642,648
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G |
Lypd6b |
LY6/PLAUR domain containing 6B |
decreases expression |
EXP |
manganese chloride results in decreased expression of LYPD6B mRNA |
CTD |
PMID:28801915 |
|
NCBI chr 3:35,271,785...35,437,296
Ensembl chr 3:35,271,786...35,437,296
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G |
Lyrm7 |
LYR motif containing 7 |
increases expression |
EXP |
manganese chloride results in increased expression of LYRM7 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr10:40,183,061...40,201,992
Ensembl chr10:40,183,078...40,201,992
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G |
Lyrm9 |
LYR motif containing 9 |
increases expression |
EXP |
manganese chloride results in increased expression of LYRM9 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr10:66,099,478...66,113,559
Ensembl chr10:66,099,531...66,113,559
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G |
Macrod2 |
mono-ADP ribosylhydrolase 2 |
increases expression |
EXP |
manganese chloride results in increased expression of MACROD2 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr 3:135,729,839...136,422,082
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G |
Madcam1 |
mucosal vascular addressin cell adhesion molecule 1 |
increases expression |
EXP |
manganese chloride results in increased expression of MADCAM1 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr 7:12,918,352...12,922,509
Ensembl chr 7:12,918,710...12,922,112
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G |
Maff |
MAF bZIP transcription factor F |
increases expression |
EXP |
manganese chloride results in increased expression of MAFF mRNA |
CTD |
PMID:28801915 |
|
NCBI chr 7:120,580,743...120,592,095
Ensembl chr 7:120,580,743...120,592,095
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G |
Mageb7 |
MAGE family member B7 |
increases expression |
EXP |
manganese chloride results in increased expression of MAGEB7 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr X:54,938,470...54,941,813
Ensembl chr X:54,938,845...54,939,919
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G |
Mall |
mal, T-cell differentiation protein-like |
decreases expression |
EXP |
manganese chloride results in decreased expression of MALL mRNA |
CTD |
PMID:26745496 |
|
NCBI chr 3:120,272,583...120,307,090
Ensembl chr 3:120,272,583...120,306,551
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G |
Map2 |
microtubule-associated protein 2 |
decreases expression |
EXP |
manganese chloride results in decreased expression of MAP2 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr 9:73,204,753...73,462,965
Ensembl chr 9:73,319,710...73,462,972
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G |
Map2k3 |
mitogen activated protein kinase kinase 3 |
decreases methylation |
ISO |
manganese chloride results in decreased methylation of MAP2K3 gene |
CTD |
PMID:27913844 |
|
NCBI chr10:45,089,455...45,110,802
Ensembl chr10:47,182,433...47,203,753 Ensembl chr10:47,182,433...47,203,753
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G |
Map2k4 |
mitogen activated protein kinase kinase 4 |
increases phosphorylation |
EXP |
manganese chloride results in increased phosphorylation of MAP2K4 protein |
CTD |
PMID:9751194 PMID:15342272 |
|
NCBI chr10:52,196,121...52,301,887
Ensembl chr10:52,196,124...52,290,657
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G |
Map3k11 |
mitogen-activated protein kinase kinase kinase 11 |
increases phosphorylation |
EXP |
manganese chloride results in increased phosphorylation of MAP3K11 protein |
CTD |
PMID:15342272 |
|
NCBI chr 1:221,043,119...221,056,420
Ensembl chr 1:221,043,119...221,056,417
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G |
Map3k7 |
mitogen activated protein kinase kinase kinase 7 |
increases methylation |
ISO |
manganese chloride results in increased methylation of MAP3K7 gene |
CTD |
PMID:27913844 |
|
NCBI chr 5:47,183,142...47,244,424
Ensembl chr 5:47,186,558...47,244,416 Ensembl chr 9:47,186,558...47,244,416
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G |
Map4k3 |
mitogen-activated protein kinase kinase kinase kinase 3 |
decreases expression |
EXP |
manganese chloride results in decreased expression of MAP4K3 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr 6:3,276,732...3,444,519
Ensembl chr 6:3,276,738...3,444,519
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G |
Map7 |
microtubule-associated protein 7 |
increases expression |
EXP |
manganese chloride results in increased expression of MAP7 mRNA |
CTD |
PMID:28801915 |
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NCBI chr 1:15,620,665...15,748,203
Ensembl chr 1:15,620,653...15,748,203
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G |
Map7d2 |
MAP7 domain containing 2 |
increases methylation decreases expression |
EXP |
manganese chloride results in increased methylation of MAP7D2 gene manganese chloride results in decreased expression of MAP7D2 mRNA |
CTD |
PMID:28801915 |
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NCBI chr X:38,400,578...38,467,825
Ensembl chr X:38,397,261...38,468,360
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G |
Mapk1 |
mitogen activated protein kinase 1 |
multiple interactions increases phosphorylation decreases phosphorylation increases activity |
EXP ISO |
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [manganese chloride results in increased phosphorylation of MAPK1 protein]; [manganese chloride results in increased abundance of Manganese] which results in increased phosphorylation of MAPK1 protein; GW 506033X promotes the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased phosphorylation of MAPK1 protein]; manganese chloride results in increased phosphorylation of and results in increased activity of MAPK1 protein; pyrazolanthrone promotes the reaction [manganese chloride results in increased phosphorylation of MAPK1 protein]; Resveratrol inhibits the reaction [manganese chloride results in increased phosphorylation of MAPK1 protein]; U 0126 inhibits the reaction [manganese chloride results in increased phosphorylation of MAPK1 protein] NTF3 protein inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in decreased phosphorylation of MAPK1 protein] [manganese chloride results in increased abundance of Manganese] which results in decreased phosphorylation of MAPK1 protein; benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in decreased phosphorylation of MAPK1 protein] manganese chloride results in decreased phosphorylation of MAPK1 protein manganese chloride results in increased activity of MAPK1 protein |
CTD |
PMID:15010209 PMID:15342272 PMID:16787641 PMID:19084589 PMID:20152896 PMID:20937724 PMID:23811825 PMID:24324973 PMID:25981801 PMID:30040983 PMID:31676349 PMID:32574669 |
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NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
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G |
Mapk11 |
mitogen-activated protein kinase 11 |
increases expression |
EXP |
manganese chloride results in increased expression of MAPK11 mRNA |
CTD |
PMID:28801915 |
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NCBI chr 7:130,121,678...130,129,199
Ensembl chr 7:130,121,687...130,128,604
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G |
Mapk14 |
mitogen activated protein kinase 14 |
increases phosphorylation increases expression |
ISO |
manganese chloride results in increased phosphorylation of MAPK14 protein manganese chloride results in increased expression of MAPK14 mRNA |
CTD |
PMID:15737199 PMID:17467022 |
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NCBI chr20:5,933,290...5,995,137
Ensembl chr20:5,933,303...5,995,137
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G |
Mapk3 |
mitogen activated protein kinase 3 |
multiple interactions increases phosphorylation decreases phosphorylation increases activity |
EXP ISO |
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [manganese chloride results in increased phosphorylation of MAPK3 protein]; [manganese chloride results in increased abundance of Manganese] which results in increased phosphorylation of MAPK3 protein; GW 506033X promotes the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased phosphorylation of MAPK3 protein]; manganese chloride results in increased phosphorylation of and results in increased activity of MAPK3 protein; pyrazolanthrone promotes the reaction [manganese chloride results in increased phosphorylation of MAPK3 protein]; Resveratrol inhibits the reaction [manganese chloride results in increased phosphorylation of MAPK3 protein]; U 0126 inhibits the reaction [manganese chloride results in increased phosphorylation of MAPK3 protein] [manganese chloride results in increased abundance of Manganese] which results in decreased phosphorylation of MAPK3 protein; benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in decreased phosphorylation of MAPK3 protein] NTF3 protein inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in decreased phosphorylation of MAPK3 protein] manganese chloride results in decreased phosphorylation of MAPK3 protein manganese chloride results in increased activity of MAPK3 protein |
CTD |
PMID:15010209 PMID:15342272 PMID:16787641 PMID:19084589 PMID:20152896 PMID:20937724 PMID:23811825 PMID:24324973 PMID:25981801 PMID:30040983 PMID:31676349 PMID:32574669 |
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NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
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G |
Mapk8 |
mitogen-activated protein kinase 8 |
increases activity multiple interactions increases methylation increases phosphorylation |
ISO EXP |
manganese chloride results in increased activity of MAPK8 protein [manganese chloride results in increased abundance of Manganese] which results in increased phosphorylation of MAPK8 protein; pyrazolanthrone inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased phosphorylation of MAPK8 protein] manganese chloride results in increased methylation of MAPK8 gene manganese chloride results in increased phosphorylation of MAPK8 protein |
CTD |
PMID:19084589 PMID:20152896 PMID:24324973 PMID:27913844 PMID:30951808 PMID:32574669 |
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NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
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G |
Mapk9 |
mitogen-activated protein kinase 9 |
increases activity increases phosphorylation |
ISO |
manganese chloride results in increased activity of MAPK9 protein manganese chloride results in increased phosphorylation of MAPK9 protein |
CTD |
PMID:19084589 PMID:20152896 |
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NCBI chr10:35,333,859...35,374,364
Ensembl chr10:35,333,859...35,374,355
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G |
Mapt |
microtubule-associated protein tau |
multiple interactions increases phosphorylation |
EXP |
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [manganese chloride results in increased phosphorylation of MAPT protein]; [Lithium Chloride results in decreased activity of GSK3B protein] inhibits the reaction [manganese chloride results in increased phosphorylation of MAPT protein]; GSK3B protein affects the reaction [manganese chloride results in increased phosphorylation of MAPT protein] |
CTD |
PMID:20937724 |
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NCBI chr10:92,289,002...92,386,517
Ensembl chr10:92,288,910...92,386,517
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G |
Masp1 |
MBL associated serine protease 1 |
decreases methylation |
ISO |
manganese chloride results in decreased methylation of MASP1 gene |
CTD |
PMID:27913844 |
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NCBI chr11:80,736,424...80,806,278
Ensembl chr11:80,736,576...80,803,382
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G |
Matn3 |
matrilin 3 |
decreases expression |
EXP |
manganese chloride results in decreased expression of MATN3 mRNA |
CTD |
PMID:28801915 |
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NCBI chr 6:34,071,428...34,091,048
Ensembl chr 6:34,071,428...34,091,048
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G |
Mbp |
myelin basic protein |
increases expression |
ISO |
manganese chloride results in increased expression of MBP mRNA |
CTD |
PMID:17175027 |
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NCBI chr18:79,326,738...79,437,310
Ensembl chr18:79,326,738...79,437,310
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G |
Mcf2l |
MCF.2 cell line derived transforming sequence-like |
increases expression |
ISO |
manganese chloride results in increased expression of MCF2L mRNA |
CTD |
PMID:15295902 |
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NCBI chr16:81,839,686...81,986,007
Ensembl chr16:81,839,653...81,980,027
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G |
Mchr1 |
melanin-concentrating hormone receptor 1 |
increases expression |
ISO |
manganese chloride results in increased expression of MCHR1 mRNA |
CTD |
PMID:17175027 |
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NCBI chr 7:122,456,846...122,459,324
Ensembl chr 7:122,456,799...122,459,960
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G |
Mcl1 |
MCL1 apoptosis regulator, BCL2 family member |
decreases expression |
EXP |
manganese chloride results in decreased expression of MCL1 protein |
CTD |
PMID:27107493 |
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NCBI chr 2:197,786,212...197,788,992
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G |
Mcm4 |
minichromosome maintenance complex component 4 |
decreases expression |
ISO |
manganese chloride results in decreased expression of MCM4 mRNA |
CTD |
PMID:17175027 |
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NCBI chr11:89,511,191...89,524,892
Ensembl chr11:89,511,191...89,524,892
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G |
Mcm5 |
minichromosome maintenance complex component 5 |
decreases expression |
ISO |
manganese chloride results in decreased expression of MCM5 mRNA |
CTD |
PMID:17175027 |
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NCBI chr19:14,523,482...14,561,281
Ensembl chr19:14,523,554...14,561,278
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G |
Mcoln3 |
mucolipin TRP cation channel 3 |
increases expression |
EXP |
manganese chloride results in increased expression of MCOLN3 mRNA |
CTD |
PMID:26745496 |
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NCBI chr 2:251,930,532...252,007,722
Ensembl chr 2:251,983,339...252,007,560
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G |
Mdm2 |
MDM2 proto-oncogene |
increases expression |
EXP |
manganese chloride results in increased expression of MDM2 mRNA |
CTD |
PMID:28801915 |
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NCBI chr 7:60,719,060...60,743,618
Ensembl chr 7:60,719,066...60,743,328
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G |
Me3 |
malic enzyme 3 |
increases expression |
ISO |
manganese chloride results in increased expression of ME3 mRNA |
CTD |
PMID:17175027 |
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NCBI chr 1:153,861,535...154,058,608
Ensembl chr 1:153,861,569...154,056,654
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G |
Medag |
mesenteric estrogen-dependent adipogenesis |
increases expression |
EXP |
manganese chloride results in increased expression of MEDAG mRNA |
CTD |
PMID:28801915 |
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NCBI chr12:6,711,745...6,730,959
Ensembl chr12:6,711,747...6,740,714
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G |
Mef2c |
myocyte enhancer factor 2C |
decreases expression increases methylation |
EXP |
manganese chloride results in decreased expression of MEF2C mRNA manganese chloride results in increased methylation of MEF2C gene |
CTD |
PMID:28801915 |
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NCBI chr 2:11,658,534...11,822,788
Ensembl chr 2:11,658,568...11,822,787
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G |
Mepe |
matrix extracellular phosphoglycoprotein |
increases methylation increases expression |
EXP |
manganese chloride results in increased methylation of MEPE gene manganese chloride results in increased expression of MEPE mRNA |
CTD |
PMID:28801915 |
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NCBI chr14:6,782,011...6,793,561
Ensembl chr14:6,782,012...6,793,558
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G |
Metap2 |
methionyl aminopeptidase 2 |
multiple interactions increases activity |
ISO |
manganese chloride inhibits the reaction [Triazoles results in decreased activity of METAP2 protein] manganese chloride results in increased activity of METAP2 protein |
CTD |
PMID:12718546 |
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NCBI chr 7:34,762,241...34,789,456
Ensembl chr 7:34,762,231...34,789,479
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G |
Mfap2 |
microfibril associated protein 2 |
decreases expression decreases methylation |
EXP |
manganese chloride results in decreased expression of MFAP2 mRNA manganese chloride results in decreased methylation of MFAP2 gene |
CTD |
PMID:28801915 |
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NCBI chr 5:159,534,202...159,539,750
Ensembl chr 5:159,534,202...159,539,750
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G |
Mfn2 |
mitofusin 2 |
decreases expression |
ISO |
manganese chloride results in decreased expression of MFN2 mRNA; manganese chloride results in decreased expression of MFN2 protein |
CTD |
PMID:28539244 |
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NCBI chr 5:164,684,244...164,715,414
Ensembl chr 5:164,684,509...164,714,145
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G |
Mfsd6 |
major facilitator superfamily domain containing 6 |
increases expression |
EXP |
manganese chloride results in increased expression of MFSD6 mRNA |
CTD |
PMID:28801915 |
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NCBI chr 9:53,626,412...53,710,820
Ensembl chr 9:53,626,592...53,710,817
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G |
Mga |
MAX dimerization protein MGA |
increases expression |
EXP |
manganese chloride results in increased expression of MGA mRNA |
CTD |
PMID:28801915 |
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NCBI chr 3:111,669,645...111,760,822
Ensembl chr 3:111,699,021...111,759,911
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G |
Mgat1 |
alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase |
increases expression |
ISO |
manganese chloride results in increased expression of MGAT1 mRNA |
CTD |
PMID:15295902 |
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NCBI chr10:34,518,392...34,537,214
Ensembl chr10:34,519,790...34,537,210
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G |
Mgat5b |
alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B |
increases expression |
EXP |
manganese chloride results in increased expression of MGAT5B mRNA |
CTD |
PMID:28801915 |
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NCBI chr10:105,861,734...105,932,048
Ensembl chr10:105,861,743...105,932,042
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G |
Mgmt |
O-6-methylguanine-DNA methyltransferase |
increases methylation increases expression |
ISO EXP |
manganese chloride results in increased methylation of MGMT gene manganese chloride results in increased expression of MGMT mRNA |
CTD |
PMID:27913844 PMID:28801915 |
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NCBI chr 1:209,237,255...209,464,189
Ensembl chr 1:209,237,233...209,464,190
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G |
Mgp |
matrix Gla protein |
increases expression |
EXP |
manganese chloride results in increased expression of MGP mRNA |
CTD |
PMID:28801915 |
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NCBI chr 4:170,856,783...170,860,105
Ensembl chr 4:170,856,751...170,860,225
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G |
Mgst1 |
microsomal glutathione S-transferase 1 |
decreases expression |
EXP |
manganese chloride results in decreased expression of MGST1 mRNA |
CTD |
PMID:28801915 |
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NCBI chr 4:172,119,382...172,134,609
Ensembl chr 4:172,119,331...172,134,607
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G |
Mgst3 |
microsomal glutathione S-transferase 3 |
increases expression |
EXP |
manganese chloride results in increased expression of MGST3 mRNA |
CTD |
PMID:28801915 |
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NCBI chr13:85,601,499...85,622,392
Ensembl chr13:85,601,499...85,622,314
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G |
Mia |
MIA SH3 domain containing |
increases expression |
ISO EXP |
manganese chloride results in increased expression of MIA mRNA |
CTD |
PMID:17175027 PMID:28801915 |
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NCBI chr 1:83,991,577...83,993,270
Ensembl chr 1:83,991,578...83,993,270
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G |
Mical1 |
microtubule associated monooxygenase, calponin and LIM domain containing 1 |
decreases expression |
EXP |
manganese chloride results in decreased expression of MICAL1 mRNA |
CTD |
PMID:28801915 |
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NCBI chr20:46,199,981...46,211,930
Ensembl chr20:46,199,981...46,211,930
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G |
Mir107 |
microRNA 107 |
decreases expression |
ISO |
manganese chloride results in decreased expression of MIR107 mRNA |
CTD |
PMID:28986288 |
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NCBI chr 1:253,128,250...253,128,336
Ensembl chr 1:253,128,250...253,128,336
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G |
Mir125b1 |
microRNA 125b-1 |
multiple interactions |
EXP |
[manganese chloride results in increased abundance of Manganese] which results in increased expression of MIR125B1 mRNA |
CTD |
PMID:31555879 |
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NCBI chr 8:45,798,260...45,798,346
Ensembl chr 8:45,798,260...45,798,346
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G |
Mir134 |
microRNA 134 |
increases expression |
ISO |
manganese chloride results in increased expression of MIR134 mRNA |
CTD |
PMID:28986288 |
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NCBI chr 6:133,884,547...133,884,619
Ensembl chr 6:133,884,531...133,884,633
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G |
Mir139 |
microRNA 139 |
decreases expression |
ISO |
manganese chloride results in decreased expression of MIR139 mRNA |
CTD |
PMID:28986288 |
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NCBI chr 1:166,589,545...166,589,612
Ensembl chr 1:166,589,545...166,589,612
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G |
Mir146b |
microRNA 146b |
decreases expression |
ISO |
manganese chloride results in decreased expression of MIR146B mRNA |
CTD |
PMID:28986288 |
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NCBI chr 1:266,089,488...266,089,575
Ensembl chr 1:266,089,488...266,089,575
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G |
Mir298 |
microRNA 298 |
decreases expression |
ISO |
manganese chloride results in decreased expression of MIR298 mRNA |
CTD |
PMID:28986288 |
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NCBI chr 3:172,357,943...172,358,024
Ensembl chr 3:172,357,943...172,358,024
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G |
Mir29a |
microRNA 29a |
decreases expression |
ISO |
manganese chloride results in decreased expression of MIR29A mRNA |
CTD |
PMID:28986288 |
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NCBI chr 4:58,343,931...58,344,018
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G |
Mir320a |
microRNA 320a |
increases expression |
ISO |
manganese chloride results in increased expression of MIR320A mRNA |
CTD |
PMID:28986288 |
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NCBI chr15:52,134,276...52,134,357
Ensembl chr15:52,134,276...52,134,357
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G |
Mir328 |
microRNA 328 |
decreases expression |
ISO |
manganese chloride results in decreased expression of MIR328 mRNA |
CTD |
PMID:28986288 |
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NCBI chr19:37,263,199...37,263,282
Ensembl chr19:37,263,199...37,263,282
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G |
Mir409 |
microRNA 409 |
decreases expression |
ISO |
manganese chloride results in decreased expression of MIR409 mRNA |
CTD |
PMID:28986288 |
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NCBI chr 6:133,893,419...133,893,495
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G |
Mir433 |
microRNA 433 |
decreases expression |
ISO |
manganese chloride results in decreased expression of MIR433 mRNA |
CTD |
PMID:28986288 |
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NCBI chr 6:133,712,334...133,712,426
Ensembl chr 6:133,712,334...133,712,426
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G |
Mir582 |
microRNA 582 |
multiple interactions |
EXP |
[manganese chloride results in increased abundance of Manganese] which results in decreased expression of MIR582 mRNA |
CTD |
PMID:31555879 |
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NCBI chr 2:40,863,750...40,863,830
Ensembl chr 2:40,863,750...40,863,830
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G |
Mir98 |
microRNA 98 |
decreases expression |
ISO |
manganese chloride results in decreased expression of MIR98 mRNA |
CTD |
PMID:28986288 |
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NCBI chr X:21,583,875...21,583,982
Ensembl chr X:21,583,875...21,583,982
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G |
Mirlet7b |
microRNA let-7b |
increases expression |
ISO |
manganese chloride results in increased expression of MIRLET7B mRNA |
CTD |
PMID:28986288 |
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NCBI chr 7:126,590,627...126,590,711
Ensembl chr 7:126,590,627...126,590,711
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G |
Mmab |
metabolism of cobalamin associated B |
decreases expression |
EXP |
manganese chloride results in decreased expression of MMAB mRNA |
CTD |
PMID:28801915 |
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NCBI chr12:47,920,712...47,935,438
Ensembl chr12:47,920,743...47,935,525
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G |
Mmp13 |
matrix metallopeptidase 13 |
increases expression |
EXP |
manganese chloride results in increased expression of MMP13 mRNA |
CTD |
PMID:26745496 |
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NCBI chr 8:5,522,739...5,533,018
Ensembl chr 8:5,522,739...5,533,018
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G |
Mmp14 |
matrix metallopeptidase 14 |
decreases expression increases methylation |
EXP |
manganese chloride results in decreased expression of MMP14 mRNA manganese chloride results in increased methylation of MMP14 gene |
CTD |
PMID:28801915 |
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NCBI chr15:33,074,441...33,083,666
Ensembl chr15:33,074,441...33,083,655
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G |
Mmp24 |
matrix metallopeptidase 24 |
increases expression |
EXP |
manganese chloride results in increased expression of MMP24 mRNA |
CTD |
PMID:28801915 |
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NCBI chr 3:151,307,309...151,355,401
Ensembl chr 3:151,310,598...151,355,401
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G |
Mmp3 |
matrix metallopeptidase 3 |
increases expression |
EXP |
manganese chloride results in increased expression of MMP3 mRNA |
CTD |
PMID:26745496 |
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NCBI chr 8:5,676,608...5,698,579
Ensembl chr 8:5,676,665...5,698,579
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G |
Mmp9 |
matrix metallopeptidase 9 |
multiple interactions increases expression |
EXP |
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [manganese chloride results in increased expression of and results in increased secretion of MMP9 protein]; manganese chloride results in increased expression of and results in increased secretion of MMP9 protein; resveratrol inhibits the reaction [manganese chloride results in increased expression of and results in increased secretion of MMP9 protein]; resveratrol inhibits the reaction [manganese chloride results in increased expression of MMP9 mRNA] |
CTD |
PMID:23811825 |
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NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
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G |
Mnda |
myeloid cell nuclear differentiation antigen |
decreases expression |
EXP |
manganese chloride results in decreased expression of IFI204 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr13:92,073,664...92,091,335
Ensembl chr13:92,073,668...92,089,980
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G |
Mob3b |
MOB kinase activator 3B |
increases expression |
EXP |
manganese chloride results in increased expression of MOB3B mRNA |
CTD |
PMID:28801915 |
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NCBI chr 5:50,437,444...50,638,136
Ensembl chr 5:50,438,576...50,638,136
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G |
Mon2 |
MON2 homolog, regulator of endosome-to-Golgi trafficking |
decreases expression |
EXP |
manganese chloride results in decreased expression of MON2 mRNA |
CTD |
PMID:28801915 |
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NCBI chr 7:66,717,470...66,794,041
Ensembl chr 7:66,717,267...66,792,492
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G |
Mpc1l |
mitochondrial pyruvate carrier 1-like |
increases expression |
EXP |
manganese chloride results in increased expression of MPC1L mRNA |
CTD |
PMID:28801915 |
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NCBI chr X:11,098,849...11,105,312
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G |
Mpo |
myeloperoxidase |
multiple interactions increases activity |
ISO EXP |
diphenyleneiodonium inhibits the reaction [manganese chloride promotes the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased activity of MPO protein]]; manganese chloride promotes the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased activity of MPO protein]; manganese chloride promotes the reaction [Tetradecanoylphorbol Acetate results in increased activity of MPO protein]; Sodium Azide inhibits the reaction [manganese chloride promotes the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased activity of MPO protein]] manganese chloride results in increased activity of MPO protein [manganese chloride results in increased abundance of Manganese] promotes the reaction [Ethanol results in increased activity of MPO protein]; [manganese chloride results in increased abundance of Manganese] which results in increased activity of MPO protein; Ethanol promotes the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased activity of MPO protein]; Quercetin inhibits the reaction [manganese chloride results in increased activity of MPO protein] |
CTD |
PMID:22906169 PMID:28040552 PMID:30844427 PMID:33314588 |
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NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
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G |
Mpp3 |
membrane palmitoylated protein 3 |
increases expression |
EXP |
manganese chloride results in increased expression of MPP3 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr10:89,930,270...89,959,462
Ensembl chr10:89,930,241...89,959,176
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G |
Mrps10 |
mitochondrial ribosomal protein S10 |
decreases expression |
EXP |
manganese chloride results in decreased expression of MRPS10 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr 9:15,637,427...15,651,154
Ensembl chr 9:15,637,268...15,646,846
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G |
Ms4a6a |
membrane spanning 4-domains A6A |
increases expression |
EXP |
manganese chloride results in increased expression of MS4A6A mRNA |
CTD |
PMID:28801915 |
|
NCBI chr 1:227,919,284...227,932,637
Ensembl chr 1:227,919,301...227,932,603
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G |
Msh5 |
mutS homolog 5 |
increases expression |
EXP |
manganese chloride results in increased expression of MSH5 mRNA |
CTD |
PMID:28801915 |
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NCBI chr20:5,020,690...5,037,125
Ensembl chr20:5,020,667...5,037,088
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Msh6 |
mutS homolog 6 |
decreases expression |
ISO |
manganese chloride results in decreased expression of MSH6 mRNA |
CTD |
PMID:17175027 |
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NCBI chr 6:11,644,565...11,662,389
Ensembl chr 6:11,644,578...11,662,499
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Msx2 |
msh homeobox 2 |
decreases expression |
EXP |
manganese chloride results in decreased expression of MSX2 mRNA |
CTD |
PMID:28801915 |
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NCBI chr17:11,683,862...11,689,527
Ensembl chr17:11,683,862...11,689,527
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G |
Mt1 |
metallothionein 1 |
decreases expression |
EXP |
manganese chloride results in decreased expression of MT1A mRNA |
CTD |
PMID:12387356 |
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NCBI chr19:11,301,991...11,303,007
Ensembl chr17:78,793,336...78,793,724
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Mt3 |
metallothionein 3 |
increases expression |
EXP |
manganese chloride results in increased expression of MT3 mRNA |
CTD |
PMID:28801915 |
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NCBI chr19:11,324,708...11,326,112
Ensembl chr19:11,324,698...11,326,139
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G |
Mta1 |
metastasis associated 1 |
increases expression |
EXP |
manganese chloride results in increased expression of MTA1 mRNA |
CTD |
PMID:28801915 |
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NCBI chr 6:137,911,302...137,950,066
Ensembl chr 6:137,924,293...137,950,075
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G |
Mtap |
methylthioadenosine phosphorylase |
increases expression |
EXP |
manganese chloride results in increased expression of MTAP mRNA |
CTD |
PMID:28801915 |
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NCBI chr 5:107,711,077...107,777,530
Ensembl chr 5:107,711,077...107,777,530
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G |
Mthfd2 |
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase |
increases expression increases methylation |
EXP |
manganese chloride results in increased expression of MTHFD2 mRNA manganese chloride results in increased methylation of MTHFD2 gene |
CTD |
PMID:28801915 |
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NCBI chr 4:115,004,433...115,015,965
Ensembl chr 4:115,004,448...115,015,965
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Mthfd2l |
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like |
increases expression |
EXP |
manganese chloride results in increased expression of MTHFD2L mRNA |
CTD |
PMID:28801915 |
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NCBI chr14:18,640,274...18,721,298
Ensembl chr14:18,640,277...18,720,357
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G |
Mtm1 |
myotubularin 1 |
decreases expression |
ISO |
manganese chloride results in decreased expression of MTM1 mRNA |
CTD |
PMID:17175027 |
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NCBI chr 6:18,821,821...18,840,449
Ensembl chr 6:18,821,815...18,839,409
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Mtmr10 |
myotubularin related protein 10 |
increases expression |
EXP |
manganese chloride results in increased expression of MTMR10 mRNA |
CTD |
PMID:28801915 |
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NCBI chr 1:125,124,743...125,175,857
Ensembl chr 1:125,124,743...125,175,857
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Mtmr6 |
myotubularin related protein 6 |
decreases expression |
EXP |
manganese chloride results in decreased expression of MTMR6 mRNA |
CTD |
PMID:28801915 |
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NCBI chr15:40,558,917...40,597,311
Ensembl chr15:40,558,932...40,597,309
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Mtor |
mechanistic target of rapamycin kinase |
decreases phosphorylation multiple interactions increases phosphorylation |
EXP ISO |
manganese chloride results in decreased phosphorylation of MTOR protein corynoxine B promotes the reaction [manganese chloride results in decreased phosphorylation of MTOR protein] manganese chloride results in increased phosphorylation of MTOR protein |
CTD |
PMID:23604964 PMID:30578841 |
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NCBI chr 5:165,263,813...165,373,967
Ensembl chr 5:165,263,800...165,373,967
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Mxd4 |
Max dimerization protein 4 |
decreases expression |
EXP |
manganese chloride results in decreased expression of MXD4 mRNA |
CTD |
PMID:28801915 |
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NCBI chr14:81,819,415...81,833,456
Ensembl chr14:81,819,415...81,833,456
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Myh13 |
myosin heavy chain 13 |
increases expression |
EXP |
manganese chloride results in increased expression of MYH13 mRNA |
CTD |
PMID:28801915 |
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NCBI chr10:53,873,089...53,920,698
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Myh2 |
myosin heavy chain 2 |
decreases expression |
EXP |
manganese chloride results in decreased expression of MYH2 mRNA |
CTD |
PMID:26745496 |
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NCBI chr10:53,711,895...53,738,164
Ensembl chr10:53,713,938...53,848,347
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Mylk2 |
myosin light chain kinase 2 |
increases expression |
EXP |
manganese chloride results in increased expression of MYLK2 mRNA |
CTD |
PMID:28801915 |
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NCBI chr 3:148,386,185...148,397,851
Ensembl chr 3:148,386,189...148,399,501
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Mylk3 |
myosin light chain kinase 3 |
increases expression |
EXP |
manganese chloride results in increased expression of MYLK3 mRNA |
CTD |
PMID:28801915 |
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NCBI chr19:27,388,163...27,442,451
Ensembl chr19:27,404,712...27,441,536
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Myoc |
myocilin |
increases methylation |
EXP |
manganese chloride results in increased methylation of MYOC gene |
CTD |
PMID:28801915 |
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NCBI chr13:80,517,531...80,527,928
Ensembl chr13:80,517,536...80,527,928
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Myom1 |
myomesin 1 |
increases expression decreases expression |
ISO EXP |
manganese chloride results in increased expression of MYOM1 mRNA manganese chloride results in decreased expression of MYOM1 mRNA |
CTD |
PMID:17175027 PMID:28801915 |
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NCBI chr 9:119,353,840...119,469,196
Ensembl chr 9:119,353,840...119,468,715
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