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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3731
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Sod1
Name: superoxide dismutase 1
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sod1increases expressionEXP 6480464CTDBenzo(a)pyrene results in increased expression of SOD1 proteinPMID:16456883
Sod1multiple interactionsEXP 6480464CTDBenzo(a)pyrene promotes the reaction [sodium arsenite results in increased expression of SOD1 protein]; sodium arsenite promotes the reaction [Benzo(a)pyrene results in increased expression of SOD1 protein]PMID:16456883
Sod1decreases activityISOSod1 (Mus musculus)6480464CTDBenzo(a)pyrene results in decreased activity of SOD1 proteinPMID:36193556
Sod1decreases expressionISOSod1 (Mus musculus)6480464CTDBenzo(a)pyrene results in decreased expression of SOD1 mRNA; Benzo(a)pyrene results in decreased expression of SOD1 proteinPMID:23892563
Sod1decreases expressionISOSOD1 (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased expression of SOD1 mRNA; Benzo(a)pyrene results in decreased expression of SOD1 proteinPMID:23892563
Sod1increases expressionISOSod1 (Mus musculus)6480464CTDBenzo(a)pyrene results in increased expression of SOD1 mRNAPMID:19770486 PMID:35567930
Sod1increases expressionISOSOD1 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased expression of SOD1 mRNAPMID:31255691 PMID:32244372 PMID:32890658
Sod1increases methylationISOSOD1 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased methylation of SOD1 promoterPMID:27901495
Sod1multiple interactionsISOSod1 (Mus musculus)6480464CTD[SOD1 protein co-treated with CAT protein] inhibits the reaction [Benzo(a)pyrene results in increased abundance of Reactive Oxygen Species]; [SOD1 protein co-treated with CAT protein] promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1B1 mRNA]; [SOD1 protein co-treated with CAT protein] promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1B1 protein]; SOD1 protein inhibits the reaction [Benzo(a)pyrene results in increased abundance of Reactive Oxygen Species]; SOD1 protein promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; SOD1 protein promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]; SOD1 protein promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1B1 mRNA]; SOD1 protein promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1B1 protein]; thymoquinone inhibits the reaction [Benzo(a)pyrene results in decreased activity of SOD1 protein]PMID:19666105 PMID:36193556
Sod1multiple interactionsISOSOD1 (Homo sapiens)6480464CTD[Benzo(a)pyrene co-treated with schizandrin B] results in increased expression of SOD1 mRNA; NFE2L2 mutant form inhibits the reaction [[Benzo(a)pyrene co-treated with schizandrin B] results in increased expression of SOD1 mRNA]PMID:25946486
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