Gene Chemical Interaction Report - Rat Genome Database

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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID:	3731
Species:	Rattus norvegicus
RGD Object:	Gene
Symbol:	Sod1
Name:	superoxide dismutase 1

Acc ID:	CHEBI:18145
Term:	(R,R,R)-alpha-tocopherol
Definition:	An alpha-tocopherol that has R,R,R configuration. The naturally occurring stereoisomer of alpha-tocopherol, it is found particularly in sunflower and olive oils.
Chemical ID:	MESH:D024502

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Object Symbol	Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
Sod1	increases expression	EXP		6480464	CTD	alpha-Tocopherol results in increased expression of SOD1 mRNA; alpha-Tocopherol results in increased expression of SOD1 protein	PMID:22732938
Sod1	multiple interactions	EXP		6480464	CTD	[alpha-Tocopherol co-treated with Ascorbic Acid] inhibits the reaction [arsenite results in increased expression of SOD1 protein]; alpha-Tocopherol inhibits the reaction [Malathion results in increased activity of SOD1 protein]	PMID:20194575 PMID:21344382
Sod1	increases expression	ISO	SOD1 (Homo sapiens)	6480464	CTD	alpha-Tocopherol results in increased expression of SOD1 mRNA; alpha-Tocopherol results in increased expression of SOD1 protein	PMID:19083475
Sod1	multiple interactions	ISO	SOD1 (Homo sapiens)	6480464	CTD	alpha-Tocopherol inhibits the reaction [Hexachlorobenzene results in increased activity of SOD1 protein]	PMID:26365763

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