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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3731
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Sod1
Name: superoxide dismutase 1
Acc ID: CHEBI:17243
Term: mono(2-ethylhexyl) phthalate
Definition: The mono(2-ethylhexyl) ester of benzene-1,2-dicarboxylic acid.
Chemical ID: MESH:C016599
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sod1decreases expressionEXP 6480464CTDmono-(2-ethylhexyl)phthalate results in decreased expression of SOD1 mRNAPMID:32566080
Sod1increases expressionISOSod1 (Mus musculus)6480464CTDmono-(2-ethylhexyl)phthalate results in increased expression of SOD1 mRNA; mono-(2-ethylhexyl)phthalate results in increased expression of SOD1 proteinPMID:20438828 PMID:37692514 PMID:37975621
Sod1multiple interactionsISOSod1 (Mus musculus)6480464CTDAcetylcysteine inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased expression of SOD1 protein]; Melatonin inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased expression of SOD1 mRNA]; Melatonin inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased expression of SOD1 protein]PMID:37692514 PMID:37975621
Sod1multiple interactionsISOSOD1 (Homo sapiens)6480464CTD[monoethyl phthalate co-treated with mono-(2-ethylhexyl)phthalate co-treated with monobutyl phthalate co-treated with mono-isobutyl phthalate co-treated with monoisononylphthalate co-treated with mono-benzyl phthalate] results in increased expression of SOD1 mRNAPMID:35861251
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