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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3674
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Shox2
Name: SHOX homeobox 2
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Shox2decreases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in decreased expression of SHOX2 mRNAPMID:32109520
Shox2decreases expressionISOShox2 (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in decreased expression of SHOX2 mRNAPMID:16922920 PMID:19933214
Shox2increases expressionISOShox2 (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in increased expression of SHOX2 mRNAPMID:20130022 PMID:24058054 PMID:26139165
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