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Gene: Shox2 (short stature homeobox 2) Mus musculus
Symbol: Shox2
Name: short stature homeobox 2
Description: Exhibits sequence-specific DNA binding activity. Involved in several processes, including animal organ development; positive regulation of cell development; and regulation of transcription by RNA polymerase II. Predicted to localize to the nucleus. Used to study Leri-Weill dyschondrosteosis. Human ortholog(s) of this gene implicated in lung cancer. Is expressed in several structures, including central nervous system; embryo mesenchyme; genitourinary system; heart; and sensory organ. Orthologous to human SHOX2 (short stature homeobox 2); INTERACTS WITH (S)-nicotine; 2,3,7,8-tetrachlorodibenzodioxine; 3,4-methylenedioxymethamphetamine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 6330543G17Rik; homeobox protein Og12X; OG-12; OG12; Og12x; paired family homeodomain protein Prx3; Prx3; short stature homeobox protein 2; SHOT
Homo sapiens (human) : SHOX2 (short stature homeobox 2)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Shox2 (short stature homeobox 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Shox2 (short stature homeobox 2)
Pan paniscus (bonobo/pygmy chimpanzee) : SHOX2 (short stature homeobox 2)
Canis lupus familiaris (dog) : SHOX2 (short stature homeobox 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Shox2 (short stature homeobox 2)
Sus scrofa (pig) : SHOX2 (short stature homeobox 2)
Chlorocebus sabaeus (green monkey) : SHOX2 (short stature homeobox 2)
Heterocephalus glaber (naked mole-rat) : Shox2 (short stature homeobox 2)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl366,971,727 - 66,981,771 (-)Ensembl
GRCm38366,971,723 - 66,981,771 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37366,777,188 - 66,785,693 (-)NCBIGRCm37mm9NCBIm37
MGSCv36367,061,195 - 67,069,700 (-)NCBImm8
Celera367,107,372 - 67,117,391 (-)NCBICelera
Cytogenetic Map3 E1NCBI
cM Map330.76NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Shox2
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 11290
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2019-12-18
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.