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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3645
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ccl2
Name: C-C motif chemokine ligand 2
Acc ID: CHEBI:64090
Term: tert-butyl hydroperoxide
Definition: An alkyl hydroperoxide in which the alkyl group is tert-butyl. It is widely used in a variety of oxidation processes.
Chemical ID: MESH:D020122
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ccl2decreases expressionISOCCL2 (Homo sapiens)6480464CTDtert-Butylhydroperoxide results in decreased expression of CCL2 mRNAPMID:20847119
Ccl2multiple interactionsISOCCL2 (Homo sapiens)6480464CTD[pioglitazone co-treated with tert-Butylhydroperoxide] results in decreased expression of CCL2 mRNA; [rosiglitazone co-treated with tert-Butylhydroperoxide] results in decreased expression of CCL2 mRNA; [troglitazone co-treated with tert-Butylhydroperoxide] results in decreased expression of CCL2 mRNA; tert-Butylhydroperoxide promotes the reaction [PPARG protein binds to CCL2 promoter]; troglitazone inhibits the reaction [tert-Butylhydroperoxide promotes the reaction [PPARG protein binds to CCL2 promoter]]; troglitazone inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of CCL2 mRNA]PMID:20847119
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