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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3645
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ccl2
Name: C-C motif chemokine ligand 2
Acc ID: CHEBI:4784
Term: enalapril
Definition: A dicarboxylic acid monoester that is ethyl 4-phenylbutanoate in which a hydrogen alpha to the carboxy group is substituted by the amino group of L-alanyl-L-proline (S-configuration).
Chemical ID: MESH:D004656
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ccl2decreases expressionEXP 6480464CTDEnalapril results in decreased expression of CCL2 mRNAPMID:10925121 PMID:19627010
Ccl2multiple interactionsEXP 6480464CTD[paricalcitol co-treated with Enalapril] results in decreased expression of CCL2 proteinPMID:17513326
Ccl2decreases expressionISOCcl2 (Mus musculus)6480464CTDEnalapril results in decreased expression of CCL2 proteinPMID:20720404 PMID:25037058
Ccl2multiple interactionsISOCcl2 (Mus musculus)6480464CTD[paricalcitol co-treated with Enalapril] results in decreased expression of CCL2 proteinPMID:20720404
Ccl2multiple interactionsISOCCL2 (Homo sapiens)6480464CTDEnalapril inhibits the reaction [sodium arsenite results in increased secretion of CCL2 protein]PMID:28973481
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