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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3645
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ccl2
Name: C-C motif chemokine ligand 2
Acc ID: CHEBI:41423
Term: celecoxib
Definition: A member of the class of pyrazoles that is 1H-pyrazole which is substituted at positions 1, 3 and 5 by 4-sulfamoylphenyl, trifluoromethyl and p-tolyl groups, respectively. A cyclooxygenase-2 inhibitor, it is used in the treatment of arthritis.
Chemical ID: MESH:C105934
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ccl2multiple interactionsEXP 6480464CTDCelecoxib inhibits the reaction [Dietary Fats results in increased expression of CCL2 mRNA]; Celecoxib inhibits the reaction [Dietary Fats results in increased expression of CCL2 protein]PMID:20039930
Ccl2decreases expressionISOCcl2 (Mus musculus)6480464CTDCelecoxib results in decreased expression of CCL2 mRNAPMID:12902868
Ccl2multiple interactionsISOCcl2 (Mus musculus)6480464CTDCelecoxib inhibits the reaction [lead acetate results in increased secretion of CCL2 protein]PMID:24530660
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