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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3554
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ren
Name: renin
Acc ID: CHEBI:6541
Term: losartan
Definition: A biphenylyltetrazole where a 1,1'-biphenyl group is attached at the 5-position and has an additional trisubstituted imidazol-1-ylmethyl group at the 4'-position
Chemical ID: MESH:D019808
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Renincreases activityEXP 6480464CTDLosartan results in increased activity of REN proteinPMID:9431853
Renincreases expressionEXP 6480464CTDLosartan results in increased expression of REN mRNA; Losartan results in increased expression of REN proteinPMID:12013499 PMID:1387008 PMID:16221218 PMID:8382237 PMID:9431853 PMID:9533614
Renmultiple interactionsEXP 6480464CTD[Lisinopril co-treated with Losartan] results in increased expression of REN mRNA; Losartan inhibits the reaction [Ethanol results in increased activity of REN protein]; Losartan promotes the reaction [Isoproterenol results in increased expression of REN protein]PMID:11709406 PMID:16221218 PMID:22982071
Renincreases activityISOREN (Homo sapiens)6480464CTDLosartan results in increased activity of REN proteinPMID:7965263 PMID:8403307
Renincreases expressionISORen1 (Mus musculus)6480464CTDLosartan results in increased expression of REN proteinPMID:9245700
Renmultiple interactionsISORen1 (Mus musculus)6480464CTDLosartan inhibits the reaction [AGT protein results in increased expression of REN1 protein]PMID:28578904
Renmultiple interactionsISOREN (Homo sapiens)6480464CTD[Losartan results in decreased activity of AGTR1 protein] which results in increased expression of REN protein; Losartan inhibits the reaction [AGT protein results in increased expression of REN protein]; Losartan promotes the reaction [Hydrochlorothiazide results in increased expression of REN protein]PMID:12569265 PMID:28578904 PMID:9124547
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