Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3554
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ren
Name: renin
Acc ID: CHEBI:26710
Term: sodium chloride
Definition: An inorganic chloride salt having sodium(1+) as the counterion.
Chemical ID: MESH:D012965
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Renincreases activityEXP 6480464CTDSodium Chloride deficiency results in increased activity of REN proteinPMID:11832429
Renincreases expressionEXP 6480464CTDSodium Chloride deficiency results in increased expression of REN mRNA; Sodium Chloride results in increased expression of REN1 proteinPMID:11832429 PMID:15134804
Renmultiple interactionsEXP 6480464CTD[Desoxycorticosterone Acetate co-treated with Sodium Chloride] results in decreased expression of REN protein; [Desoxycorticosterone co-treated with Sodium Chloride] results in decreased expression of REN protein; [Ozone co-treated with Oxygen] inhibits the reaction [[Desoxycorticosterone Acetate co-treated with Sodium Chloride] results in decreased expression of REN protein]; Ramipril promotes the reaction [Sodium Chloride deficiency results in increased activity of REN protein]; Ramipril promotes the reaction [Sodium Chloride deficiency results in increased expression of REN mRNA]; Sodium Chloride inhibits the reaction [Methylprednisolone results in increased activity of REN protein]PMID:11039 PMID:11832429 PMID:235222 PMID:26550192
Renincreases expressionISORen1 (Mus musculus)6480464CTDSodium Chloride deficiency results in increased expression of REN mRNAPMID:19474190
Renmultiple interactionsISORen1 (Mus musculus)6480464CTD[Sodium Chloride deficiency co-treated with Enalapril] results in increased expression of REN mRNA; GJA5 affects the reaction [Sodium Chloride deficiency results in increased expression of REN mRNA]; REN enhancer mutant form results in decreased susceptibility to [Sodium Chloride deficiency co-treated with Enalapril]PMID:17846348 PMID:19474190
Go Back to source page   Continue to Ontology report