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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3531
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Raf1
Name: Raf-1 proto-oncogene, serine/threonine kinase
Acc ID: CHEBI:34873
Term: N-nitrosodiethylamine
Definition: A nitrosamine that is N-ethylethanamine substituted by a nitroso group at the N-atom.
Chemical ID: MESH:D004052
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Raf1increases expressionEXP 6480464CTDDiethylnitrosamine results in increased expression of RAF1 mRNAPMID:2559087
Raf1multiple interactionsEXP 6480464CTD[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of RAF1 protein; [Diethylnitrosamine co-treated with Polychlorinated Biphenyls] results in increased expression of RAF1 protein; [indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in increased expression of RAF1 mRNA; [indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of RAF1 mRNAPMID:22129741 PMID:7526561
Raf1multiple interactionsISORaf1 (Mus musculus)6480464CTD[troglitazone co-treated with Diethylnitrosamine] results in decreased expression of RAF1 mRNAPMID:18597072
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