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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3442
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pth1r
Name: parathyroid hormone 1 receptor
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pth1raffects expressionEXP 6480464CTDbisphenol A affects the expression of PTH1R mRNAPMID:25181051
Pth1rdecreases expressionEXP 6480464CTDbisphenol A results in decreased expression of PTH1R mRNAPMID:30816183 PMID:32528016
Pth1rincreases methylationEXP 6480464CTDbisphenol A results in increased methylation of PTH1R genePMID:28505145
Pth1rdecreases methylationISOPth1r (Mus musculus)6480464CTDbisphenol A results in decreased methylation of PTH1R promoterPMID:27312807
Pth1rincreases expressionISOPth1r (Mus musculus)6480464CTDbisphenol A results in increased expression of PTH1R mRNAPMID:34585602
Pth1rmultiple interactionsISOPTH1R (Homo sapiens)6480464CTD[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of PTH1R mRNAPMID:28628672
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