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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3439
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ptgs1
Name: prostaglandin-endoperoxide synthase 1
Acc ID: CHEBI:8887
Term: rofecoxib
Definition: A butenolide that is furan-2(5H)-one substituted by a phenyl group at position 3 and by a p-(methylsulfonyl)phenyl group at position 4. A selective cyclooxygenase 2 inhibitor, it was used from 1999 to 2004 for the treatment of ostoarthritis, but was withdrawn following concerns about an associated increased risk of heart attack and stroke.
Chemical ID: MESH:C116926
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ptgs1decreases activityISOPTGS1 (Homo sapiens)6480464CTDrofecoxib analog results in decreased activity of PTGS1 protein; rofecoxib results in decreased activity of PTGS1 proteinPMID:16141368
Ptgs1decreases expressionISOPTGS1 (Homo sapiens)6480464CTDrofecoxib results in decreased expression of PTGS1 mRNAPMID:17175104
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